{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T09:57:30Z","timestamp":1792403850281,"version":"4.4.0"},"reference-count":39,"publisher":"American Physiological Society","issue":"5","funder":[{"DOI":"10.13039\/100000050","name":"HHS | NIH | National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["5R01HL136710-03"],"award-info":[{"award-number":["5R01HL136710-03"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.physiology.org"],"crossmark-restriction":true},"short-container-title":["Journal of Neurophysiology"],"published-print":{"date-parts":[[2021,5,1]]},"abstract":"<jats:p>Previous in vitro studies suggest that 5-HT<jats:sub>2A<\/jats:sub>receptors contribute to eupnea and are necessary for fictive gasping. The current study shows that the impaired gasping displayed by neonatal TPH2<jats:sup>\u2212\/\u2212<\/jats:sup>mice deficient in CNS serotonin is restored by a 5-HT<jats:sub>2A<\/jats:sub>receptor activation. Following 5-HT<jats:sub>2A<\/jats:sub>blockade, wild-type mice hypoventilated and their gasping resembled that of TPH2<jats:sup>\u2212\/\u2212<\/jats:sup>mice. This study shows that both eupnea and gasping in vivo rely on the activation of 5-HT<jats:sub>2A<\/jats:sub>receptors.<\/jats:p>","DOI":"10.1152\/jn.00088.2021","type":"journal-article","created":{"date-parts":[[2021,3,24]],"date-time":"2021-03-24T20:15:51Z","timestamp":1616616951000},"page":"1543-1551","update-policy":"https:\/\/doi.org\/10.1152\/aps-crossmark-policy","source":"Crossref","is-referenced-by-count":10,"title":["Eupnea and gasping in vivo are facilitated by the activation of 5-HT<sub>2A<\/sub>receptors"],"prefix":"10.1152","volume":"125","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4100-8856","authenticated-orcid":false,"given":"Kevin J.","family":"Cummings","sequence":"first","affiliation":[{"name":"Department of Biomedical Sciences, College of Veterinary Medicine, University of Missouri, Columbia, Missouri and Dalton Cardiovascular Research Center, University of Missouri, Columbia, Missouri"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2011.214445"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1016\/j.resp.2007.06.002"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1963-09.2009"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00003.2013"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00336.2011"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.90729.2008"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1055\/s-2002-33678"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1001\/jama.296.17.2124"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1093\/jnen\/nlz062"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-199903000-00010"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.10287"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2007.01.032"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2004.06.023"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1152\/jn.2001.86.1.104"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1038\/nn1650"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2237-04.2005"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4186-05.2006"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1523\/jneurosci.22-24-11055.2002"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00599.2007"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00071.2007"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.2009.0076"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.107.091033"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2009.06.051"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1007\/pl00005315"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1016\/0896-6273(93)90149-l"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1007\/s002130050605"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00213.2015"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1998.85.1.84"},{"key":"B29","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1542\/peds.16.1.81","volume":"16","author":"Drorbaugh JE","year":"1955","journal-title":"Pediatrics"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00970.2013"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5271-08.2009"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(81)90146-9"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1871-04.2004"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1016\/j.resp.2008.06.007"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1681.2009.05301.x"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1124\/pr.111.004697"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.01375.2006"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000176970.22603.8d"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2004.01.031"}],"container-title":["Journal of Neurophysiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.physiology.org\/doi\/pdf\/10.1152\/jn.00088.2021","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,12,22]],"date-time":"2022-12-22T10:33:48Z","timestamp":1671705228000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.physiology.org\/doi\/10.1152\/jn.00088.2021"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5,1]]},"references-count":39,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2021,5,1]]}},"alternative-id":["10.1152\/jn.00088.2021"],"URL":"https:\/\/doi.org\/10.1152\/jn.00088.2021","relation":{},"ISSN":["0022-3077","1522-1598"],"issn-type":[{"value":"0022-3077","type":"print"},{"value":"1522-1598","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,5,1]]},"assertion":[{"value":"2021-02-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-03-19","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-04-26","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}