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During wakefulness and stage 2 and slow wave (stages 3 and 4) sleep, we measured mean arterial blood pressure (MAP), Paco<jats:sub>2<\/jats:sub>, and absolute CBF. With triazolam compared to placebo, MAP reduced gradually. During stage 2 sleep, Paco<jats:sub>2<\/jats:sub>increased and whole-brain mean CBF decreased. With triazolam, relative rCBF of the left orbital basal forebrain decreased more during stage 2 than slow wave sleep, whereas absolute CBF of the occipital cortex and cerebral white matter remained constant. During triazolam-induced stage 2 sleep, absolute CBF of the cerebral white matter correlated more strongly to both MAP and Paco<jats:sub>2<\/jats:sub>than during placebo sleep and also correlated more strongly to both MAP and Paco<jats:sub>2<\/jats:sub>than absolute CBF of the occipital cortex. In the frontal white matter, during triazolam-induced stage 2 sleep compared to wakefulness, absolute CBF was significantly better correlated to MAP, but not to Paco<jats:sub>2<\/jats:sub>. During triazolam-induced stage 2, the cerebral white matter may receive a modulated CBF regulation having the strengthened relationship of Paco<jats:sub>2<\/jats:sub>to CBF and, more locally, the frontal white matter may depend precariously on CBF regulation.<\/jats:p>","DOI":"10.1152\/jn.00114.2005","type":"journal-article","created":{"date-parts":[[2005,10,27]],"date-time":"2005-10-27T00:33:58Z","timestamp":1130373238000},"page":"2293-2303","source":"Crossref","is-referenced-by-count":3,"title":["Effect of Benzodiazepine Hypnotic Triazolam on Relationship of Blood Pressure and Pa<scp>co<\/scp><sub>2<\/sub>to Cerebral Blood Flow During Human Non-Rapid Eye Movement Sleep"],"prefix":"10.1152","volume":"95","author":[{"given":"Masahiko","family":"Hiroki","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naofumi","family":"Kajimura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takeshi","family":"Uema","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenichi","family":"Ogawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masami","family":"Nishikawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masaaki","family":"Kato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tsuyoshi","family":"Watanabe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toru","family":"Nakajima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harumasa","family":"Takano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Etsuko","family":"Imabayashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Ohnishi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yutaka","family":"Takayama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Matsuda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Makoto","family":"Uchiyama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masako","family":"Okawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kiyohisa","family":"Takahashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hidenao","family":"Fukuyama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"24","reference":[{"key":"R1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(92)90239-Z"},{"key":"R2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/120.7.1173"},{"key":"R3","doi-asserted-by":"publisher","DOI":"10.1152\/jn.2001.85.2.900"},{"key":"R4","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(03)02981-0"},{"key":"R5","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(91)90232-K"},{"key":"R6","doi-asserted-by":"publisher","DOI":"10.1097\/00002826-199619060-00002"},{"key":"R7","unstructured":"Fatterpekar GM, Naidich TP, Delman BN, Aguinaldo JG, Gultekin SH, Sherwood CC, Hof PR, Drayer BP, and Fayad ZA.Cytoarchitecture of the human cerebral cortex: MR microscopy of excised specimens at 9.4 Tesla.Am J Neuroradiol23: 1313\u20131321, 2002."},{"key":"R8","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2869.2000.00191.x"},{"key":"R9","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.1990.tb03603.x"},{"key":"R10","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.1983.33"},{"key":"R11","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.460020402"},{"key":"R12","doi-asserted-by":"crossref","unstructured":"Galindo A, Vargas ML, Garcia Estan J, Fuentes T, and Hernandez J.Synergistic interaction of diazepam with 3\u2032,5\u2032-cyclic adenosine monophosphate-elevating agents on rat aortic rings.Eur J Pharmacol5: 269\u2013275, 2001.","DOI":"10.1016\/S0014-2999(01)01335-8"},{"key":"R13","doi-asserted-by":"publisher","DOI":"10.1016\/0893-133X(95)00234-5"},{"key":"R14","doi-asserted-by":"publisher","DOI":"10.1007\/BF00248217"},{"key":"R15","unstructured":"Herscovitch P, Markham J, and Raichle ME.Brain blood flow measured with intravenous H215O. 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