{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T17:46:50Z","timestamp":1785433610423,"version":"3.56.0"},"reference-count":58,"publisher":"American Physiological Society","issue":"3","license":[{"start":{"date-parts":[[2025,2,26]],"date-time":"2025-02-26T00:00:00Z","timestamp":1740528000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/100000002","name":"HHS | National Institutes of Health","doi-asserted-by":"publisher","award":["NIH R01HL133100"],"award-info":[{"award-number":["NIH R01HL133100"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"HHS | National Institutes of Health","doi-asserted-by":"publisher","award":["R01HL128970"],"award-info":[{"award-number":["R01HL128970"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","award":["19CDA34700025"],"award-info":[{"award-number":["19CDA34700025"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","award":["828142"],"award-info":[{"award-number":["828142"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","award":["24CDA1270910"],"award-info":[{"award-number":["24CDA1270910"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.physiology.org"],"crossmark-restriction":true},"short-container-title":["Journal of Neurophysiology"],"published-print":{"date-parts":[[2025,3,1]]},"abstract":"<jats:p>\n                    Obesity and comorbid sleep apnea are key predisposing factors to hypertension. Obesity increases circulating leptin levels and hyperleptinemia may contribute to hypertension but mechanisms are not clear. Here, we have shown that knockdown of the leptin receptor LepR\n                    <jats:sup>b<\/jats:sup>\n                    in the carotid body decreased blood pressure and treated hypertension in diet-induced obese mice. Thus, we identified a novel mechanism of obesity hypertension and a novel drug target, LepR\n                    <jats:sup>b<\/jats:sup>\n                    in the carotid body.\n                  <\/jats:p>","DOI":"10.1152\/jn.00133.2024","type":"journal-article","created":{"date-parts":[[2025,2,4]],"date-time":"2025-02-04T10:57:32Z","timestamp":1738666652000},"page":"892-903","update-policy":"https:\/\/doi.org\/10.1152\/aps-crossmark-policy","source":"Crossref","is-referenced-by-count":3,"title":["Leptin receptor downregulation in the carotid body treats obesity-induced hypertension"],"prefix":"10.1152","volume":"133","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0755-157X","authenticated-orcid":false,"given":"Mi-Kyung","family":"Shin","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00y4zzh67","id-type":"ROR","asserted-by":"publisher"}],"name":"George Washington University School of Medicine and Health Sciences","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lenise J.","family":"Kim","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00y4zzh67","id-type":"ROR","asserted-by":"publisher"}],"name":"George Washington University School of Medicine and Health Sciences","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-6983-1611","authenticated-orcid":false,"given":"Dashdulam","family":"Davaanyam","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00y4zzh67","id-type":"ROR","asserted-by":"publisher"}],"name":"George Washington University School of Medicine and Health Sciences","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8490-4853","authenticated-orcid":false,"given":"Mateus R.","family":"Amorim","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00y4zzh67","id-type":"ROR","asserted-by":"publisher"}],"name":"George Washington University School of Medicine and Health Sciences","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9897-3315","authenticated-orcid":false,"given":"Sean M.","family":"Lee","sequence":"additional","affiliation":[{"name":"George Washington University","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wan-Yee","family":"Tang","sequence":"additional","affiliation":[{"name":"University of Pittsburgh Graduate School of Public Health","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2951-7535","authenticated-orcid":false,"given":"Vsevolod Y.","family":"Polotsky","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00y4zzh67","id-type":"ROR","asserted-by":"publisher"}],"name":"George Washington University School of Medicine and Health Sciences","place":["United States"]},{"name":"George Washington University School of Medicine and Health Sciences","place":["United States"]},{"name":"George Washington University School of Medicine and Health Sciences","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjhyper.2004.05.017"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.118.12191"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1111\/jch.13666"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kws342"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199304293281704"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1210\/jcem.85.3.6484"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2009.10.005"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.165.5.2104087"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.2109080"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1001\/jama.283.14.1829"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200005113421901"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.110.165969"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1306766"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1378\/chest.13-0085"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199602013340503"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1038\/nm1195-1155"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1007\/s13679-016-0231-x"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.4061\/2011\/270624"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1038\/ajh.2009.244"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1080\/10641963.2018.1557684"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.119.315338"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2014.00398"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00215.2023"},{"key":"B24","first-page":"73","volume-title":"Handbook of Clinical Neurology","author":"L\u00f3pez-Barneo J","year":"2022"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.120.16527"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.01133.2013"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2012.237800"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.111.00064"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.2337\/db12-1463"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1992.72.5.1978"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacbts.2016.06.004"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1016\/j.jash.2015.03.006"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/zsab046"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1111\/j.1753-4887.1998.tb01685.x"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.2741\/3885"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1016\/j.physbeh.2014.04.003"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1007\/s11684-013-0263-5"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/zsy089"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00386.2022"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1113\/JP283678"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.3791\/60298"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1007\/s10753-021-01617-6"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-019-1512-6"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00114.2015"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2009.05033.x"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1016\/s0031-9384(01)00613-8"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.121.319874"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1038\/s41366-019-0500-3"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(88)92867-x"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.81.2.700"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.81.2.528"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2021.688375"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1113\/JP276900"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1113\/JP275362"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-201x.2000.00746.x"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.1999.276.1.H215"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2013.00026"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2014.10.058"}],"container-title":["Journal of Neurophysiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.physiology.org\/doi\/pdf\/10.1152\/jn.00133.2024","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,10]],"date-time":"2025-04-10T14:59:42Z","timestamp":1744297182000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.physiology.org\/doi\/10.1152\/jn.00133.2024"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,1]]},"references-count":58,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,3,1]]}},"alternative-id":["10.1152\/jn.00133.2024"],"URL":"https:\/\/doi.org\/10.1152\/jn.00133.2024","relation":{},"ISSN":["0022-3077","1522-1598"],"issn-type":[{"value":"0022-3077","type":"print"},{"value":"1522-1598","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3,1]]},"assertion":[{"value":"2024-04-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-05-13","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-01-26","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-02-26","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}