{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T16:46:43Z","timestamp":1773420403385,"version":"3.50.1"},"reference-count":125,"publisher":"American Physiological Society","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Neurophysiology"],"published-print":{"date-parts":[[2014,11,15]]},"abstract":"<jats:p>The role that posterior parietal (PPC) and motor cortices play in modulating neural responses in somatosensory areas 1 and 2 was examined with reversible deactivation by transient cooling. Multiunit recordings from neurons in areas 1 and 2 were collected from six anesthetized adult monkeys ( Macaca mulatta) before, during, and after reversible deactivation of areas 5L or 7b or motor cortex (M1\/PM), while select locations on the hand and forelimb were stimulated. Response changes were quantified as increases and decreases to stimulus-driven activity relative to baseline and analyzed during three recording epochs: during deactivation (\u201ccool\u201d) and at two time points after deactivation (\u201crewarm 1,\u201d \u201crewarm 2\u201d). Although the type of response change observed was variable, for neurons at the recording sites tested &gt;90% exhibited a significant change in response during cooling of 7b while cooling area 5L or M1\/PM produced a change in 75% and 64% of sites, respectively. These results suggest that regions in the PPC, and to a lesser extent motor cortex, shape the response characteristics of neurons in areas 1 and 2 and that this kind of feedback modulation is necessary for normal somatosensory processing. Furthermore, this modulation appears to happen on a minute-by-minute basis and may serve as the substrate for phenomena such as somatosensory attention.<\/jats:p>","DOI":"10.1152\/jn.00141.2014","type":"journal-article","created":{"date-parts":[[2014,8,21]],"date-time":"2014-08-21T03:25:25Z","timestamp":1408591525000},"page":"2545-2560","source":"Crossref","is-referenced-by-count":17,"title":["Reversible deactivation of higher-order posterior parietal areas. II. Alterations in response properties of neurons in areas 1 and 2"],"prefix":"10.1152","volume":"112","author":[{"given":"Adam B.","family":"Goldring","sequence":"first","affiliation":[{"name":"Center for Neuroscience, University of California, Davis, California;"},{"name":"Department of Psychology, University of California, Davis, California;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dylan F.","family":"Cooke","sequence":"additional","affiliation":[{"name":"Center for Neuroscience, University of California, Davis, California;"},{"name":"Department of Psychology, University of California, Davis, California;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mary K. L.","family":"Baldwin","sequence":"additional","affiliation":[{"name":"Department of Psychology, University of California, Davis, California;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gregg H.","family":"Recanzone","sequence":"additional","affiliation":[{"name":"Department of Psychology, University of California, Davis, California;"},{"name":"Department of Neurobiology, Physiology, and Behavior, University of California, Davis, California; and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adam G.","family":"Gordon","sequence":"additional","affiliation":[{"name":"Center for Neuroscience, University of California, Davis, California;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tingrui","family":"Pan","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, University of California, Davis, California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Scott I.","family":"Simon","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, University of California, Davis, California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leah","family":"Krubitzer","sequence":"additional","affiliation":[{"name":"Center for Neuroscience, University of California, Davis, California;"},{"name":"Department of Psychology, University of California, Davis, California;"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00231655"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(00)03285-6"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(73)90518-0"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2011.02.004"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1002\/cne.23499"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2010.07094.x"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1152\/jn.2001.85.2.539"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5479-08.2009"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(72)90771-8"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1126\/science.1077395"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.2002.1277"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/9.7.662"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1002\/cne.903550404"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1002\/cne.903550405"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1080\/08990220050117574"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1080\/08990229770971"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1126\/science.1138071"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2905-09.2009"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5708-09.2009"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902870402"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902870403"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1152\/jn.2000.83.3.1550"},{"key":"B23","first-page":"319","volume":"97","author":"Chapman C","year":"1991","journal-title":"Exp Brain Res"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00303.2005"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1152\/jn.90942.2008"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1986.55.6.1352"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00140.2014"},{"key":"B28","author":"Cooke DF","year":"2011","journal-title":"2011 Neuroscience Meeting Planner"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1152\/jn.01101.2011"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1980.43.5.1319"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0084367"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2007.09.031"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.3109\/07367228509144574"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1002\/cne.903350205"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9861(19990726)410:2<211::AID-CNE4>3.0.CO;2-X"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2009.09.035"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1994.72.2.542"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1126\/science.172.3980.273"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/1.1.1"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1570-06.2006"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1139\/y88-074"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00558.2006"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1980.43.2.444"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1152\/jn.01031.2006"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(90)90213-U"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhp308"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhq260"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1989.62.6.1287"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1991.66.5.1493"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1992.67.6.1437"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2009.07.064"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1016\/0168-0102(95)00950-7"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0084196"},{"key":"B54","volume-title":"Resampling Methods: A Practical Guide to Data Analysis","author":"Good PI","year":"2005"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1002\/cne.20933"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1993.70.1.444"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2006.12.081"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(81)90533-3"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/97.1.673"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1978.sp012518"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1978.sp012517"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1980.43.4.870"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.1038\/nn1734"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.1038\/369554a0"},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.1007\/BF00229023"},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(80)91139-7"},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-4328(02)00164-X"},{"key":"B68","first-page":"327","volume":"51","author":"Iwamura Y","year":"1983","journal-title":"Exp Brain Res"},{"key":"B69","first-page":"315","volume":"51","author":"Iwamura Y","year":"1983","journal-title":"Exp Brain Res"},{"key":"B70","first-page":"412","volume":"58","author":"Iwamura Y","year":"1985","journal-title":"Exp Brain Res"},{"key":"B71","first-page":"400","volume":"58","author":"Iwamura Y","year":"1985","journal-title":"Exp Brain Res"},{"key":"B72","doi-asserted-by":"publisher","DOI":"10.1017\/S0952523811000411"},{"key":"B73","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2969-10.2010"},{"key":"B74","doi-asserted-by":"publisher","DOI":"10.1126\/science.107591"},{"key":"B75","doi-asserted-by":"publisher","DOI":"10.1002\/cne.901770409"},{"key":"B76","doi-asserted-by":"publisher","DOI":"10.1002\/cne.20025"},{"key":"B77","doi-asserted-by":"publisher","DOI":"10.1038\/nn.3544"},{"key":"B78","first-page":"299","volume":"34","author":"Leinonen L","year":"1979","journal-title":"Exp Brain Res"},{"key":"B79","first-page":"321","volume":"34","author":"Leinonen L","year":"1979","journal-title":"Exp Brain Res"},{"key":"B80","doi-asserted-by":"publisher","DOI":"10.1002\/1096-9861(20001204)428:1<112::AID-CNE8>3.0.CO;2-9"},{"key":"B81","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-0270(98)00165-4"},{"key":"B82","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00372.2012"},{"key":"B83","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1977.40.2.362"},{"key":"B84","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00121.2002"},{"key":"B85","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1113\/jphysiol.1993.sp019713","volume":"466","author":"Michalski A","year":"1993","journal-title":"J Physiol"},{"key":"B86","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1975.38.4.871"},{"key":"B87","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1992.68.3.703"},{"key":"B88","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5124-12.2013"},{"key":"B89","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0623-11.2011"},{"key":"B90","doi-asserted-by":"publisher","DOI":"10.1002\/cne.901920402"},{"key":"B91","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhn229"},{"key":"B92","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhi071"},{"key":"B93","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2632-07.2007"},{"key":"B94","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1806-10.2010"},{"key":"B95","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1659-12.2013"},{"key":"B96","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2010.07.054"},{"key":"B97","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.1000305"},{"key":"B98","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.85.4.1317"},{"key":"B99","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5362-10.2011"},{"key":"B100","doi-asserted-by":"publisher","DOI":"10.1038\/nn2039"},{"key":"B101","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902400103"},{"key":"B102","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(85)90492-5"},{"key":"B103","doi-asserted-by":"publisher","DOI":"10.1126\/science.3603028"},{"key":"B104","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902480303"},{"key":"B105","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhj076"},{"key":"B106","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2008.06395.x"},{"key":"B107","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2501-12.2012"},{"key":"B108","doi-asserted-by":"publisher","DOI":"10.1007\/BF00240498"},{"key":"B109","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902950212"},{"key":"B110","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhr257"},{"key":"B111","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00385.2012"},{"key":"B112","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0015342"},{"key":"B113","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3720-05.2006"},{"key":"B114","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(80)90762-3"},{"key":"B115","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1992.67.2.411"},{"key":"B116","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1995.73.3.1063"},{"key":"B117","doi-asserted-by":"publisher","DOI":"10.1152\/jn.01166.2003"},{"key":"B118","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0024860"},{"key":"B119","doi-asserted-by":"publisher","DOI":"10.1162\/jocn_a_00235"},{"key":"B120","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902240204"},{"key":"B121","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00804.2012"},{"key":"B122","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902370309"},{"key":"B123","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1996.76.6.3633"},{"key":"B124","doi-asserted-by":"publisher","DOI":"10.1152\/jn.2001.85.5.1823"},{"key":"B125","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5193-12.2013"}],"container-title":["Journal of Neurophysiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.physiology.org\/doi\/pdf\/10.1152\/jn.00141.2014","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T18:31:52Z","timestamp":1717266712000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.physiology.org\/doi\/10.1152\/jn.00141.2014"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,11,15]]},"references-count":125,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2014,11,15]]}},"alternative-id":["10.1152\/jn.00141.2014"],"URL":"https:\/\/doi.org\/10.1152\/jn.00141.2014","relation":{},"ISSN":["0022-3077","1522-1598"],"issn-type":[{"value":"0022-3077","type":"print"},{"value":"1522-1598","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,11,15]]}}}