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The origin of OPC vulnerability in HIBD, however, remains controversial. In this study, we defined the HIBD punctate lesions by MRI diffuse excessive high signal intensity (DEHSI) in postnatal 7-day-old rats. The electrophysiological functional properties of OPCs in HIBD were recorded by patch-clamp in acute cerebral cortex slices. The slices were intracellularly injected with Lucifer yellow and immunohistochemically labeled with NG2 antibody to identify local OPCs. Passive membrane properties and K<jats:sup>+<\/jats:sup> channel functions in OPCs were analyzed to estimate the onset of vulnerability in HIBD. The resting membrane potential, membrane resistance, and membrane capacitance of OPCs were increased in both the gray and white matter of the cerebral cortex. OPCs in both the gray and white matter exhibited voltage-dependent K<jats:sup>+<\/jats:sup> currents, which consisted of the initiated rectified potassium currents ( I<jats:sub>A<\/jats:sub>) and the sustained rectified currents ( I<jats:sub>K<\/jats:sub>). The significant alternation in membrane resistance was influenced by the diversity of potassium channel kinetics. These findings suggest that the rectification of I<jats:sub>A<\/jats:sub> and I<jats:sub>K<\/jats:sub> channels may play a significant role in OPC vulnerability in HIBD. <\/jats:p>","DOI":"10.1152\/jn.00144.2014","type":"journal-article","created":{"date-parts":[[2014,10,29]],"date-time":"2014-10-29T23:38:50Z","timestamp":1414625930000},"page":"592-600","source":"Crossref","is-referenced-by-count":8,"title":["Alteration in rectification of potassium channels in perinatal hypoxia ischemia brain damage"],"prefix":"10.1152","volume":"113","author":[{"given":"Penghui","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Neurobiology, The Third Military Medical University, Chongqing, China; and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liyan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Xinqiao Hospital, The Third Military Medical University, Chongqing, 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