{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T14:09:30Z","timestamp":1792678170430,"version":"4.5.0"},"reference-count":68,"publisher":"American Physiological Society","issue":"2","funder":[{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","award":["1516288"],"award-info":[{"award-number":["1516288"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","award":["1724240"],"award-info":[{"award-number":["1724240"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"HHS | NIH | National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["R01NS101016"],"award-info":[{"award-number":["R01NS101016"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"HHS | NIH | National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["R01NS104835"],"award-info":[{"award-number":["R01NS104835"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"HHS | NIH | National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["F31NS101821"],"award-info":[{"award-number":["F31NS101821"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"HHS | NIH | National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["R21NS095103"],"award-info":[{"award-number":["R21NS095103"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"HHS | NIH | National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["F31NS101821"],"award-info":[{"award-number":["F31NS101821"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Neurophysiology"],"published-print":{"date-parts":[[2020,8,1]]},"abstract":"<jats:p>This work introduces a novel method to detect spike oscillations amidst neural noise. Using this method, we demonstrate that delta oscillations in the basal ganglia are a defining feature of awake, dopamine-depleted mice and are strongly correlated with dopamine loss and parkinsonian motor symptoms. These oscillations arise from a loss of D2-receptor activation and do not require motor cortex. Similar oscillations in human patients may be an underappreciated marker and target for Parkinson\u2019s disease (PD) treatment.<\/jats:p>","DOI":"10.1152\/jn.00158.2020","type":"journal-article","created":{"date-parts":[[2020,6,24]],"date-time":"2020-06-24T15:26:26Z","timestamp":1593012386000},"page":"312-329","source":"Crossref","is-referenced-by-count":51,"title":["Delta oscillations are a robust biomarker of dopamine depletion severity and motor dysfunction in awake mice"],"prefix":"10.1152","volume":"124","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1122-1090","authenticated-orcid":false,"given":"Timothy C.","family":"Whalen","sequence":"first","affiliation":[{"name":"Center for the Neural Basis of Cognition, Carnegie Mellon University, Pittsburgh, Pennsylvania"},{"name":"Neuroscience Institute and Department of Biological Sciences, Carnegie Mellon University, Pittsburgh, Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3485-252X","authenticated-orcid":false,"given":"Amanda M.","family":"Willard","sequence":"additional","affiliation":[{"name":"Center for the Neural Basis of Cognition, Carnegie Mellon University, Pittsburgh, Pennsylvania"},{"name":"Neuroscience Institute and Department of Biological Sciences, Carnegie Mellon University, Pittsburgh, Pennsylvania"},{"name":"Department of Biology and Geosciences, Clarion University, Clarion, Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1513-1551","authenticated-orcid":false,"given":"Jonathan E.","family":"Rubin","sequence":"additional","affiliation":[{"name":"Center for the Neural Basis of Cognition, Carnegie Mellon University, Pittsburgh, Pennsylvania"},{"name":"Department of Mathematics, University of Pittsburgh, Pittsburgh, Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aryn H.","family":"Gittis","sequence":"additional","affiliation":[{"name":"Center for the Neural Basis of Cognition, Carnegie Mellon University, Pittsburgh, Pennsylvania"},{"name":"Neuroscience Institute and Department of Biological Sciences, Carnegie Mellon University, Pittsburgh, Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4662-14.2015"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2016.02.003"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2020.104737"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3245-14.2015"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1046\/j.1460-9568.2003.02543.x"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4613-0485-2_33"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1038\/nature24064"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4137-14.2015"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0339-16.2016"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00858.2015"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1186\/s40035-018-0123-y"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresbull.2005.11.012"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2010.06.034"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2010.06.020"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1998.80.6.3380"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00590.2018"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2007.05.004"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-211-45295-0_4"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2820-14.2014"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.20-24-08987.2000"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1038\/nn.2592"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.4.1674"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00829.2004"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms4572"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2011.09.003"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2005.09.009"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1111\/ejn.12697"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0282-08.2008"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2006.04717.x"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2007.05777.x"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1985.53.4.926"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.08-03-00754.1988"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awf128"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(01)00281-0"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2012.04.027"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4199-08.2008"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2015.12.017"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2155-04.2004"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1152\/jn.91092.2008"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2824-12.2012"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1007\/s10867-008-9095-y"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2016.03.002"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2013.259721"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2009.02.010"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2012.08105.x"},{"key":"B46","volume-title":"The Mouse Brain in Stereotaxic Coordinates","author":"Paxinos G","year":"2001","edition":"2"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1038\/23281"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2004.06.001"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2008.05.008"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.20-22-08559.2000"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00055.2005"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2015.12.037"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresbull.2008.01.023"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00844.2001"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1152\/jn.90574.2008"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1126\/science.8235588"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1016\/j.conb.2005.05.007"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1523\/ENEURO.0089-19.2019"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.22-07-02963.2002"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-24629-z"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(01)02489-1"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.21-16-06430.2001"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2006.10.006"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2012.03.029"},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3611-14.2015"},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00697.2006"},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.42746"},{"key":"B68","doi-asserted-by":"crossref","first-page":"P1.8-028","DOI":"10.1212\/WNL.92.15_supplement.P1.8-028","volume":"92","author":"Zhuang P","year":"2019","journal-title":"Neurology"}],"container-title":["Journal of Neurophysiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.physiology.org\/doi\/pdf\/10.1152\/jn.00158.2020","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,8]],"date-time":"2024-08-08T06:12:48Z","timestamp":1723097568000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.physiology.org\/doi\/10.1152\/jn.00158.2020"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8,1]]},"references-count":68,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2020,8,1]]}},"alternative-id":["10.1152\/jn.00158.2020"],"URL":"https:\/\/doi.org\/10.1152\/jn.00158.2020","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2020.02.09.941161","asserted-by":"object"}]},"ISSN":["0022-3077","1522-1598"],"issn-type":[{"value":"0022-3077","type":"print"},{"value":"1522-1598","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,8,1]]}}}