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We have investigated how these conductances affect synaptic integration in a premotor nonspiking (NS) neuron of the leech nervous system. These cells exhibit an extensive neuritic tree, do not fire Na<jats:sup>+<\/jats:sup>-dependent spikes, but express an LT-VACC that was sensitive to 250 \u03bcM Ni<jats:sup>2+<\/jats:sup>and 100 \u03bcM NNC 55-0396 (NNC). NS neurons responded to excitation of mechanosensory pressure neurons with depolarizing responses for which amplitude was a linear function of the presynaptic firing frequency. NNC decreased these synaptic responses and abolished the concomitant widespread Ca<jats:sup>2+<\/jats:sup>signals. Coherent with the interpretation that the LT-VACC amplified signals at the postsynaptic level, this conductance also amplified the responses of NS neurons to direct injection of sinusoidal current. Synaptic amplification thus is achieved via a positive feedback in which depolarizing signals activate an LT-VACC that, in turn, boosts these signals. The wide distribution of LT-VACC could support the active propagation of depolarizing signals, turning the complex NS neuritic tree into a relatively compact electrical compartment.<\/jats:p>","DOI":"10.1152\/jn.00170.2015","type":"journal-article","created":{"date-parts":[[2015,5,14]],"date-time":"2015-05-14T02:42:25Z","timestamp":1431571345000},"page":"332-340","source":"Crossref","is-referenced-by-count":4,"title":["Graded boosting of synaptic signals by low-threshold voltage-activated calcium conductance"],"prefix":"10.1152","volume":"114","author":[{"given":"Mart\u00edn","family":"Carb\u00f3 Tano","sequence":"first","affiliation":[{"name":"Departamento de Fisiolog\u00eda, Biolog\u00eda Molecular y Celular, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires, Argentina; and Instituto de Fisiolog\u00eda, Biolog\u00eda Molecular y Neurociencias, Consejo Nacional de Investigaciones Cient\u00edficas y Tecnol\u00f3gicas, Ciudad Universitaria, Buenos 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