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Despite divergent etiologies, behavioral phenotypes, and neurophysiological profiles, high-frequency deep brain stimulation (HF-DBS) in the basal ganglia has been shown to be effective for both hypo- and hyperkinetic disorders. The aim of this review is to compare and contrast the electrophysiological hallmarks of PD and TS phenotypes in nonhuman primates and discuss why the same treatment (HF-DBS targeted to the globus pallidus internus, GPi-DBS) is capable of ameliorating both symptom profiles. Recent studies have shown that therapeutic GPi-DBS entrains the spiking of neurons located in the vicinity of the stimulating electrode, resulting in strong stimulus-locked modulations in firing probability with minimal changes in the population-scale firing rate. This stimulus effect normalizes\/suppresses the pathological firing patterns and dysrhythmia that underlie specific phenotypes in both the PD and TS models. We propose that the elimination of pathological states via stimulus-driven entrainment and suppression, while maintaining thalamocortical network excitability within a normal physiological range, provides a common therapeutic mechanism through which HF-DBS permits information transfer for purposive motor behavior through the CBG while ameliorating conditions with widely different symptom profiles.<\/jats:p>","DOI":"10.1152\/jn.00223.2015","type":"journal-article","created":{"date-parts":[[2015,7,16]],"date-time":"2015-07-16T02:50:06Z","timestamp":1437015006000},"page":"2090-2104","source":"Crossref","is-referenced-by-count":12,"title":["Common therapeutic mechanisms of pallidal deep brain stimulation for hypo- and hyperkinetic movement disorders"],"prefix":"10.1152","volume":"114","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8546-4095","authenticated-orcid":false,"given":"Kevin W.","family":"McCairn","sequence":"first","affiliation":[{"name":"Systems Neuroscience and Movement 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