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For WDR neurons, the latency to antidromic activation of the ventral posterior lateral nucleus of the thalamus showed no difference between the aged and adult rats. Sciatic nerve stimulation with C-fiber intensity induced responses of GN with significantly longer latency in aged rats than in adults, whereas there was no difference in the response latency to A-fiber intensity stimulation. Background activity and afterdischarges were significantly higher in the aged rats than those in the adult rats. Responses to noxious mechanical and thermal stimuli were significantly greater in the aged rats during application of graded stimuli. There were no significant differences in responses to nonnoxious mechanical stimulus, mechanical response threshold, and the size of the receptive fields between neurons in the aged and adult rats. The area occupied by SP-LI fibers in the GN and the size of SP-LI dorsal root ganglia neurons were significantly larger in aged rats than in adults. The present findings suggest that the hyperexcitability of GN neurons could be involved in abnormal noxious pain sensations with advancing age. <\/jats:p>","DOI":"10.1152\/jn.00243.2005","type":"journal-article","created":{"date-parts":[[2005,11,16]],"date-time":"2005-11-16T20:58:13Z","timestamp":1132174693000},"page":"4178-4187","source":"Crossref","is-referenced-by-count":19,"title":["Involvement of Dorsal Column Nucleus Neurons in Nociceptive Transmission in Aged Rats"],"prefix":"10.1152","volume":"94","author":[{"given":"Junichi","family":"Kitagawa","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshiyuki","family":"Tsuboi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akiko","family":"Ogawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ke","family":"Ren","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suzuro","family":"Hitomi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kimiko","family":"Saitoh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Osamu","family":"Takahashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuji","family":"Masuda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshiyuki","family":"Harada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naoki","family":"Hanzawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenro","family":"Kanda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koichi","family":"Iwata","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"24","reference":[{"key":"R1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1996.76.4.2675"},{"key":"R2","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1997.78.1.521"},{"key":"R3","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1976.39.6.1160"},{"key":"R4","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9861(19990802)410:3<368::AID-CNE2>3.0.CO;2-I"},{"key":"R5","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9861(19961111)375:2<303::AID-CNE9>3.0.CO;2-6"},{"key":"R6","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9861(19980629)396:2<211::AID-CNE6>3.0.CO;2-3"},{"key":"R7","doi-asserted-by":"publisher","DOI":"10.1038\/nm0895-766"},{"key":"R8","doi-asserted-by":"crossref","unstructured":"Brena S and Bonica JJ. 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