{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T22:28:59Z","timestamp":1776378539247,"version":"3.51.2"},"reference-count":38,"publisher":"American Physiological Society","issue":"4","funder":[{"DOI":"10.13039\/501100000143","name":"Alzheimer Society","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000143","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Gouvernement du Canada | Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["PJT153310"],"award-info":[{"award-number":["PJT153310"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Gouvernement du Canada | Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["PJT166178"],"award-info":[{"award-number":["PJT166178"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Gouvernement du Canada | Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["PJT470862"],"award-info":[{"award-number":["PJT470862"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000095","name":"Savoy Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000095","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.physiology.org"],"crossmark-restriction":true},"short-container-title":["Journal of Neurophysiology"],"published-print":{"date-parts":[[2023,10,1]]},"abstract":"<jats:p> Previous evidence suggested that different seizure onset patterns rely on the activity of distinct neuronal populations. In this study, we show for the first time that in vivo optogenetic stimulation of CaMKII principal cells in kainic acid-treated mice triggers hypersynchronous-onset seizures that are associated with fast ripples. Our findings indicate that in patients with predominant HYP-onset seizures, anticonvulsant treatments should be aimed at limiting the firing of principal neurons in the seizure onset zone. <\/jats:p>","DOI":"10.1152\/jn.00244.2023","type":"journal-article","created":{"date-parts":[[2023,9,13]],"date-time":"2023-09-13T19:50:56Z","timestamp":1694634656000},"page":"1041-1052","update-policy":"https:\/\/doi.org\/10.1152\/aps-crossmark-policy","source":"Crossref","is-referenced-by-count":7,"title":["CA3 principal cell activation triggers hypersynchronous-onset seizures in a mouse model of mesial temporal lobe epilepsy"],"prefix":"10.1152","volume":"130","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4752-2052","authenticated-orcid":false,"given":"Siyan","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Neurology & Neurosurgery, Montreal Neurological Institute-Hospital, McGill University, Montr\u00e9al, Quebec, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1593-7037","authenticated-orcid":false,"given":"Maxime","family":"L\u00e9vesque","sequence":"additional","affiliation":[{"name":"Department of Neurology & Neurosurgery, Montreal Neurological Institute-Hospital, McGill University, Montr\u00e9al, Quebec, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4948-0741","authenticated-orcid":false,"given":"Teddy A. J.","family":"Fisher","sequence":"additional","affiliation":[{"name":"Department of Neurology & Neurosurgery, Montreal Neurological Institute-Hospital, McGill University, Montr\u00e9al, Quebec, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Timothy E.","family":"Kennedy","sequence":"additional","affiliation":[{"name":"Department of Neurology & Neurosurgery, Montreal Neurological Institute-Hospital, McGill University, Montr\u00e9al, Quebec, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Massimo","family":"Avoli","sequence":"additional","affiliation":[{"name":"Department of Neurology & Neurosurgery, Montreal Neurological Institute-Hospital, McGill University, Montr\u00e9al, Quebec, Canada"},{"name":"Department of Physiology, McGill University, Montr\u00e9al, Quebec, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1016\/S0920-1211(96)00043-5"},{"key":"B2","volume-title":"The Temporal Lobe & Limbic System","author":"Gloor P","year":"1997"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1097\/WNP.0b013e31826b3ab7"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2014.59"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2004.045690"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1152\/jn.01128.2015"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2005.00268.x"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2008.01881.x"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awt299"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1155\/NP.2000.49"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2015.12.002"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5086-11.2012"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1002\/ana.24570"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2023.106097"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1002\/ana.24342"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00841.2014"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1016\/j.pneurobio.2012.02.005"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1111\/epi.13830"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1111\/epi.13121"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2018.24"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00111.2023"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81826-7"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1111\/epi.13795"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0472-13.2013"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-1063(1999)9:2<137::AID-HIPO5>3.0.CO;2-0"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3112-04.2004"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2007.07.040"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00031.2015"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1111\/epi.13251"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1038\/nn.2790"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1016\/S0920-1211(98)00127-2"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1157.2000.tb00202.x"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0404.2008.01108.x"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1016\/j.yebeh.2009.11.001"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1111\/ejn.14334"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2009.03.057"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2017.07.008"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2022.105794"}],"container-title":["Journal of Neurophysiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.physiology.org\/doi\/pdf\/10.1152\/jn.00244.2023","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,21]],"date-time":"2023-10-21T13:24:14Z","timestamp":1697894654000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.physiology.org\/doi\/10.1152\/jn.00244.2023"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10,1]]},"references-count":38,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2023,10,1]]}},"alternative-id":["10.1152\/jn.00244.2023"],"URL":"https:\/\/doi.org\/10.1152\/jn.00244.2023","relation":{},"ISSN":["0022-3077","1522-1598"],"issn-type":[{"value":"0022-3077","type":"print"},{"value":"1522-1598","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,10,1]]},"assertion":[{"value":"2023-06-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-09-13","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-09-13","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-10-18","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}