{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T23:01:49Z","timestamp":1789599709601,"version":"build-2803163510"},"reference-count":59,"publisher":"American Physiological Society","issue":"4","content-domain":{"domain":["journals.physiology.org"],"crossmark-restriction":true},"short-container-title":["Journal of Neurophysiology"],"published-print":{"date-parts":[[2025,10,1]]},"abstract":"<jats:p> This study uniquely combines cross-sectional analysis and Mendelian randomization to reveal a causal link between specific sleep disorders and stroke risk. It identifies nonorganic sleep disorders and sleep apnea as independent risk factors while suggesting a protective effect of sleepwalking. These findings offer novel genetic and observational evidence supporting targeted prevention strategies and highlight the need for further investigation into underlying mechanisms and clinical implications. <\/jats:p>","DOI":"10.1152\/jn.00246.2025","type":"journal-article","created":{"date-parts":[[2025,9,17]],"date-time":"2025-09-17T17:02:00Z","timestamp":1758128520000},"page":"1118-1132","update-policy":"https:\/\/doi.org\/10.1152\/aps-crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["Association between sleep disorders and risk of stroke: insights from cross-sectional study and Mendelian randomization"],"prefix":"10.1152","volume":"134","author":[{"given":"Fei","family":"Huang","sequence":"first","affiliation":[{"name":"North Sichuan Medical College","place":["People\u2019s Republic of China"]},{"name":"Suining Central Hospital","place":["People\u2019s Republic of China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lianlin","family":"Zeng","sequence":"additional","affiliation":[{"name":"Suining Central Hospital","place":["People\u2019s Republic of China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-3717-786X","authenticated-orcid":false,"given":"Jianjiao","family":"Mou","sequence":"additional","affiliation":[{"name":"Suining Central Hospital","place":["People\u2019s Republic of China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yangan","family":"Li","sequence":"additional","affiliation":[{"name":"Suining Central Hospital","place":["People\u2019s Republic of China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-5923-0941","authenticated-orcid":false,"given":"Kehui","family":"Hu","sequence":"additional","affiliation":[{"name":"Suining Central Hospital","place":["People\u2019s Republic of China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1186\/s12889-025-22575-w"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jstrokecerebrovasdis.2025.108308"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2025.1492691"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2025.177553"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1177\/17474930241308142"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(24)00642-1"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1097\/md.0000000000039741"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1007\/s13755-024-00320-8"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1080\/21645515.2025.2475601"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1080\/0886022x.2025.2471008"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctim.2025.103138"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1177\/08830738251331750"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2025.03.017"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1016\/j.pulmoe.2023.09.004"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcrp.2025.200387"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2017.11.1147"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2020.04.012"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2869.2011.00993.x"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2025.03.004"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2025.02.030"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1080\/09602011.2024.2370072"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1080\/25310429.2025.2470556"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1136\/bjo-2024-326554"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.7570\/jomes24031"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1016\/j.compbiolchem.2025.108422"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1016\/j.numecd.2025.103974"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-025-04881-x"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1249\/mss.0000000000003601"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2025.02.048"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/zsaf027"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1136\/openhrt-2024-002866"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejim.2024.12.020"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.01033-2024"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.3390\/ijms26030971"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24087285"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1016\/j.smrv.2025.102092"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1097\/cm9.0000000000003352"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1080\/19490976.2025.2474142"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2025.167767"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1038\/s41569-023-00846-6"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.04022-2020"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1016\/j.exger.2024.112486"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.3855\/jidc.18694"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1177\/1747493020904913"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1161\/strokeaha.119.028796"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1016\/j.jocn.2025.111185"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.12788\/j.sder.0010"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1097\/hnp.0000000000000738"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2008.12.006"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2024.06.016"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/zsy039"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1016\/j.mehy.2011.04.019"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1016\/s1474-4422(21)00321-5"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1093\/eurjpc\/zwad151"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-025-94816-2"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1038\/s42003-025-08091-y"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2025.106848"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1111\/coa.14286"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1016\/j.apmr.2025.04.012"}],"container-title":["Journal of Neurophysiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.physiology.org\/doi\/pdf\/10.1152\/jn.00246.2025","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T17:43:04Z","timestamp":1759340584000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.physiology.org\/doi\/10.1152\/jn.00246.2025"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,1]]},"references-count":59,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,10,1]]}},"alternative-id":["10.1152\/jn.00246.2025"],"URL":"https:\/\/doi.org\/10.1152\/jn.00246.2025","relation":{},"ISSN":["0022-3077","1522-1598"],"issn-type":[{"value":"0022-3077","type":"print"},{"value":"1522-1598","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,1]]},"assertion":[{"value":"2025-05-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-07-07","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-19","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-01","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}