{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T01:16:05Z","timestamp":1790385365688,"version":"4.1.0"},"reference-count":91,"publisher":"American Physiological Society","issue":"5","funder":[{"DOI":"10.13039\/100000050","name":"HHS | NIH | National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R01HL152210"],"award-info":[{"award-number":["R01HL152210"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"HHS | NIH | National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["T32HL160529"],"award-info":[{"award-number":["T32HL160529"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.physiology.org"],"crossmark-restriction":true},"short-container-title":["Journal of Neurophysiology"],"published-print":{"date-parts":[[2025,11,1]]},"abstract":"<jats:p>\n                    This study uses intersectional chemogenetics, radiotelemetry, and whole body plethysmography to determine the effect of selective stimulation of distinct sensory nerve subsets on cardiorespiratory function in awake mice. We show that TRPA1\n                    <jats:sup>+<\/jats:sup>\n                    afferents evoke greater reflex bradycardia than TRPV1\n                    <jats:sup>+<\/jats:sup>\n                    afferents. We show that P2X2\n                    <jats:sup>+<\/jats:sup>\n                    (nodose) afferents induce bradypnea through an increased time of pause, whereas Tac1\n                    <jats:sup>+<\/jats:sup>\n                    TRPV1\n                    <jats:sup>+<\/jats:sup>\n                    (jugular nociceptive) afferents induce bradypnea through prolongation of expiration. Thus, distinct afferent subsets can differentially regulate cardiorespiratory function.\n                  <\/jats:p>","DOI":"10.1152\/jn.00248.2025","type":"journal-article","created":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T16:41:44Z","timestamp":1759941704000},"page":"1540-1556","update-policy":"https:\/\/doi.org\/10.1152\/aps-crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Reflex regulation of respiration and heart rate by inhaled activators of vagal bronchopulmonary afferents"],"prefix":"10.1152","volume":"134","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7186-977X","authenticated-orcid":false,"given":"Teresa S.","family":"Darcey","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/032db5x82","id-type":"ROR","asserted-by":"publisher"}],"name":"University of South Florida","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justin Shane","family":"Hooper","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/032db5x82","id-type":"ROR","asserted-by":"publisher"}],"name":"University of South Florida","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1510-1010","authenticated-orcid":false,"given":"Sanjay S.","family":"Nair","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/032db5x82","id-type":"ROR","asserted-by":"publisher"}],"name":"University of South Florida","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karina V.","family":"Lurye","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/032db5x82","id-type":"ROR","asserted-by":"publisher"}],"name":"University of South Florida","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seol-Hee","family":"Kim","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/032db5x82","id-type":"ROR","asserted-by":"publisher"}],"name":"University of South Florida","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen H.","family":"Hadley","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/032db5x82","id-type":"ROR","asserted-by":"publisher"}],"name":"University of South Florida","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mayur J.","family":"Patil","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/032db5x82","id-type":"ROR","asserted-by":"publisher"}],"name":"University of South Florida","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5056-2699","authenticated-orcid":false,"given":"Thomas E.","family":"Taylor-Clark","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/032db5x82","id-type":"ROR","asserted-by":"publisher"}],"name":"University of South Florida","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2003.057885"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1016\/s0034-5687(97)00030-3"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.2001.91.6.2642"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1988.sp017212"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1016\/s0034-5687(00)00204-8"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1996.sp021703"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2002.022848"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(92)90239-X"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1016\/j.autneu.2009.08.001"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2003.060079"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2007.148379"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1523\/jneurosci.4354-08.2009"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1523\/eneuro.0350-23.2023"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.90382.2008"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1113\/jp278085"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00039.2015"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1152\/physiol.00017.2020"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1411032111"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2022.872446"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1152\/physiol.00050.2018"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2013.00293"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1513\/pats.200504-033sr"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1016\/j.pupt.2015.06.003"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2015.10.044"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201912-2347oc"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2005.093153"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2010.195339"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2019.04.096"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00028.2013"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00313.2017"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.161.1.9903091"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1523\/ENEURO.0203-20.2020"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1523\/ENEURO.0494-19.2020"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1523\/ENEURO.0026-22.2022"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aeh049"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-197103000-00014"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00944.2015"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.3389\/FNCIR.2014.00076"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1523\/jneurosci.6451-10.2011"},{"key":"B40","doi-asserted-by":"publisher","unstructured":"Patil MJ, Hooper JS, Kim S-H, Bahia PK, Pavelkova N, Nair SS, Darcey TS, Lurye KV, Madaram M, Fiallo J, Hadley SH, Taylor-Clark TE. Anatomical and functional mapping of vagal nociceptive sensory nerve subsets innervating the mouse lower airways by intersectional genetics. J Physiol, 2025. doi:10.1113\/JP289279.","DOI":"10.1113\/JP289279"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1002\/DVG.22949"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2010.02.037"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1021\/cn500325v"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1038\/39807"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1007\/s00408-021-00443-9"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1007\/s12576-015-0408-1"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1155\/jamc\/9923229"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1093\/chemse\/bjn029"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1086\/physzool.54.2.30155824"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.59499"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.1994.267.5.r1371"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1002\/ame2.12344"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1963.SP007100"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1002\/cphy.cp030212"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1016\/0165-1838(82)90037-6"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1113\/JPHYSIOL.2003.054890"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2006.02.023"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.4103\/0253-7613.115019"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1124\/mol.108.054445"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2019.01064"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.1159\/000514204"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-023-06680-7"},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2008-0292oc"},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.1007\/bf01969919"},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1995.SP020513"},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1989.67.4.1428"},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.1042\/cs0710519"},{"key":"B70","doi-asserted-by":"publisher","DOI":"10.1038\/nature02282"},{"key":"B71","doi-asserted-by":"publisher","DOI":"10.1523\/jneurosci.08-09-03208.1988"},{"key":"B72","doi-asserted-by":"publisher","DOI":"10.1124\/mol.112.084319"},{"key":"B73","doi-asserted-by":"publisher","DOI":"10.1016\/j.pupt.2015.08.003"},{"key":"B74","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2008.153585"},{"key":"B75","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2012.05.048"},{"key":"B76","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2007.133231"},{"key":"B77","doi-asserted-by":"publisher","DOI":"10.1038\/S41598-019-41088-2"},{"key":"B78","doi-asserted-by":"publisher","DOI":"10.1002\/cne.25398"},{"key":"B79","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2005.08.043"},{"key":"B80","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2005.104661"},{"key":"B81","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.2009.0085"},{"key":"B82","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.90360.2008"},{"key":"B83","doi-asserted-by":"publisher","DOI":"10.1006\/dbio.2001.0156"},{"key":"B84","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-019-01782-8"},{"key":"B85","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2015.00378"},{"key":"B86","doi-asserted-by":"publisher","DOI":"10.1523\/jneurosci.5128-14.2015"},{"key":"B87","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2005.04.005"},{"key":"B88","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2024.109182"},{"key":"B89","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1978.sp012152"},{"key":"B90","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00252.2006"},{"key":"B91","doi-asserted-by":"publisher","DOI":"10.1038\/nm.4501"},{"key":"B92","doi-asserted-by":"publisher","DOI":"10.1038\/s41593-018-0074-8"},{"key":"B93","doi-asserted-by":"publisher","DOI":"10.1016\/j.coph.2009.02.002"}],"container-title":["Journal of Neurophysiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.physiology.org\/doi\/pdf\/10.1152\/jn.00248.2025","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T14:41:56Z","timestamp":1761835316000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.physiology.org\/doi\/10.1152\/jn.00248.2025"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,1]]},"references-count":91,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,11,1]]}},"alternative-id":["10.1152\/jn.00248.2025"],"URL":"https:\/\/doi.org\/10.1152\/jn.00248.2025","relation":{},"ISSN":["0022-3077","1522-1598"],"issn-type":[{"value":"0022-3077","type":"print"},{"value":"1522-1598","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,1]]},"assertion":[{"value":"2025-05-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-06-20","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-15","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-30","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}