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Here, we used the marine poison palytoxin (PLTX), which converts the sodium-potassium ATPase (NKA) into an open channel, to initiate SD in intact locust CNS. We show for the first time that PLTX-induced SD is rapid and recoverable in vivo, providing support that NKA conversion to a channel may be the SD-initiating mechanism.<\/jats:p>","DOI":"10.1152\/jn.00251.2024","type":"journal-article","created":{"date-parts":[[2024,10,16]],"date-time":"2024-10-16T11:00:28Z","timestamp":1729076428000},"page":"1621-1632","update-policy":"https:\/\/doi.org\/10.1152\/aps-crossmark-policy","source":"Crossref","is-referenced-by-count":9,"title":["Palytoxin evokes reversible spreading depolarization in the locust CNS"],"prefix":"10.1152","volume":"132","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-2391-3599","authenticated-orcid":false,"given":"Yuyang","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Biology, Queen\u2019s University, Kingston, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel A.","family":"Van Dusen","sequence":"additional","affiliation":[{"name":"Department of Biology, Queen\u2019s University, Kingston, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"McGuire","sequence":"additional","affiliation":[{"name":"Department of Biomedical and Molecular Sciences, Queen\u2019s University, Kingston, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4857-7314","authenticated-orcid":false,"given":"R. 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