{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T14:05:14Z","timestamp":1761919514220,"version":"3.38.0"},"reference-count":55,"publisher":"American Physiological Society","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Neurophysiology"],"published-print":{"date-parts":[[2012,1,15]]},"abstract":"<jats:p>In the nucleus accumbens (NAc), a medium spiny (MS) neuron receives GABAergic inputs from two major sources: fast-spiking (FS) neurons and other, adjacent MS neurons. These two types of inhibitory synapses are considered to play different roles in output activities, i.e., FS\u2192MS connections suppress output from the NAc whereas MS\u2192MS connections contribute to lateral inhibition. In the present study, we focused on the electrophysiological properties of unitary inhibitory postsynaptic currents (uIPSCs) obtained from MS\u2192MS connections and FS\u2192MS connections and examined the effects of quinpirole, a dopamine D<jats:sub>2<\/jats:sub>-like receptor agonist, on uIPSCs with multiple whole cell patch-clamp recording. Application of quinpirole (1 \u03bcM) reliably suppressed the amplitude of uIPSCs by 29.6% in MS\u2192MS connections, with increases in paired-pulse ratio and failure rate. The suppressive effects of quinpirole on uIPSCs were mimicked by 1 \u03bcM PD128907, a D<jats:sub>2\/3<\/jats:sub>receptor agonist, whereas quinpirole-induced suppression of uISPCs was blocked by preapplication of 1 \u03bcM sulpiride or 10 \u03bcM nafadotride, both D<jats:sub>2\/3<\/jats:sub>receptor antagonists. On the other hand, quinpirole (1 \u03bcM) had divergent effects on FS\u2192MS connections, i.e., quinpirole increased uIPSC amplitude in 38.1% of FS\u2192MS connections and 23.8% of FS\u2192MS connections were suppressed by quinpirole. Analysis of coefficient of variation in uIPSC amplitude implied the involvement of presynaptic mechanisms in quinpirole-induced effects on uIPSCs. These results suggest that activation of D<jats:sub>2<\/jats:sub>-like receptors facilitates outputs from MS neurons in the NAc by reducing lateral inhibition during a dormant period of FS neuron activities.<\/jats:p>","DOI":"10.1152\/jn.00281.2011","type":"journal-article","created":{"date-parts":[[2011,11,3]],"date-time":"2011-11-03T03:40:11Z","timestamp":1320291611000},"page":"692-703","source":"Crossref","is-referenced-by-count":21,"title":["D<sub>2<\/sub>-like dopamine receptors differentially regulate unitary IPSCs depending on presynaptic GABAergic neuron subtypes in rat nucleus accumbens shell"],"prefix":"10.1152","volume":"107","author":[{"given":"Shuntaro","family":"Kohnomi","sequence":"first","affiliation":[{"name":"Department of Pharmacology and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noriaki","family":"Koshikawa","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and"},{"name":"Division of Oral and Craniomaxillofacial 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