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CTZ (100 \u03bcM) made the period of tonic-like discharges (161 \u00b1 18% of control) and the whole SLE (151 \u00b1 15% of control) longer (in 7 of 9 slices) or induced endless SLE by stabilizing clonic-like bursting (in 2 of 9 slices). CTZ (30 \u03bcM) had no significant effects on SLE dynamics ( n = 4), whereas 300 \u03bcM CTZ induced endless SLEs in four of eight slices. Coapplication of CTZ (100 \u03bcM) with 100 \u03bcM GYKI-52466, the allosteric inhibitor of AMPA receptor function, restrained the effects of CTZ and shortened SLEs and their tonic phases to 37 \u00b1 4.2 and 47 \u00b1 4.2% of the control, respectively. Effects of GYKI-52466 and GYKI-52466 with CTZ on SLE dynamics were indistinguishable. 4-aminopyridine (4-AP; 50 \u03bcM) alone ( n = 5) or in combination with CTZ ( n = 6) transformed recurrent SLE pattern into incessant epileptiform activity with patterns distinguishable from those under 100 \u03bcM CTZ application. The effect of 4-AP may suggest a role for facilitated presynaptic glutamate release in disrupting recurrent dynamics. In contrast, the self-similar slow-down of low [Mg<jats:sup>2+<\/jats:sup>]\u2013induced SLE dynamics by CTZ indicate AMPA receptor desensitization as a parameter shaping SLEs. <\/jats:p>","DOI":"10.1152\/jn.00287.2006","type":"journal-article","created":{"date-parts":[[2006,8,17]],"date-time":"2006-08-17T00:34:39Z","timestamp":1155774879000},"page":"3538-3544","source":"Crossref","is-referenced-by-count":11,"title":["Cyclothiazide Prolongs Low [Mg<sup>2+<\/sup>]\u2013Induced Seizure-Like Events"],"prefix":"10.1152","volume":"96","author":[{"given":"B\u00e1lint","family":"Laszt\u00f3czi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julianna","family":"Kardos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"24","reference":[{"key":"R1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(86)91274-6"},{"key":"R2","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(98)00447-8"},{"key":"R3","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2004.04.015"},{"key":"R4","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.94.26.14821"},{"key":"R5","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00764.2002"},{"key":"R6","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.17-07-02567.1997"},{"key":"R7","doi-asserted-by":"publisher","DOI":"10.1021\/jm000007r"},{"key":"R8","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5338-03.2004"},{"key":"R9","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2133370100"},{"key":"R10","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5125-04.2005"},{"key":"R11","doi-asserted-by":"publisher","DOI":"10.1016\/0896-6273(95)90098-5"},{"key":"R12","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410320504"},{"key":"R13","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(93)90754-5"},{"key":"R14","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.23-05-01840.2003"},{"key":"R15","doi-asserted-by":"publisher","DOI":"10.1111\/j.0953-816X.2004.03355.x"},{"key":"R16","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2005.03873.x"},{"key":"R17","doi-asserted-by":"publisher","DOI":"10.1016\/S0013-4694(98)00024-8"},{"key":"R18","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0511063103"},{"key":"R19","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2004.02.008"},{"key":"R20","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7793.1997.077bo.x"},{"key":"R21","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1999.81.6.3096"},{"key":"R22","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7793.2001.0423a.x"},{"key":"R23","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2005.65604.x"},{"key":"R24","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1986.56.2.409"},{"key":"R25","doi-asserted-by":"publisher","DOI":"10.1016\/S0197-0186(03)00137-2"},{"key":"R26","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2004.03231.x"},{"key":"R27","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuint.2005.12.017"},{"key":"R28","doi-asserted-by":"publisher","DOI":"10.1152\/jn.2002.88.4.1625"},{"key":"R29","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.1996.tb00735.x"},{"key":"R30","doi-asserted-by":"publisher","DOI":"10.1023\/A:1025618324593"},{"key":"R31","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.physiol.63.1.815"},{"key":"R32","doi-asserted-by":"publisher","DOI":"10.1038\/nature03328"},{"key":"R33","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(03)00559-1"},{"key":"R34","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.16-23-07496.1996"},{"key":"R35","doi-asserted-by":"crossref","unstructured":"Partin KM, Patneau DK, Winters CA, Mayer ML, and Buonanno A. 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