{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T23:02:54Z","timestamp":1791327774408,"version":"4.3.1"},"reference-count":71,"publisher":"American Physiological Society","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Neurophysiology"],"published-print":{"date-parts":[[2009,12]]},"abstract":"<jats:p> Injury or section of a peripheral nerve can promote chronic neuropathic pain. This is initiated by the appearance and persistence of ectopic spontaneous activity in primary afferent neurons that promotes a secondary, enduring increase in excitability of sensory circuits in the spinal dorsal horn (\u201ccentral sensitization\u201d). We have previously shown that 10\u201320 days of chronic constriction injury (CCI) of rat sciatic nerve produce a characteristic \u201celectrophysiological signature\u201d or pattern of changes in synaptic excitation of five different electrophysiologically defined neuronal phenotypes in the substantia gelatinosa of the dorsal horn. Although axotomy and CCI send different signals to the dorsal horn, we now find, using whole cell recording, that the \u201celectrophysiological signature\u201d produced 12\u201322 days after sciatic axotomy is quite similar to that seen with CCI. Axotomy thus has little effect on resting membrane potential, rheobase, current\u2013voltage characteristics, or excitability of most neuron types; however, it does decrease excitatory synaptic drive to tonic firing neurons, while increasing that to delay firing neurons. Since many tonic neurons are GABAergic, whereas delay neurons do not contain \u03b3-aminobutyric acid, axotomy may reduce synaptic excitation of inhibitory neurons while increasing that of excitatory neurons. Further analysis of spontaneous and miniature (tetrodotoxin-resistant) excitatory postsynaptic currents is consistent with the possibility that decreased excitation of tonic neurons reflects loss of presynaptic contacts. By contrast, increased excitation of \u201cdelay\u201d neurons may reflect increased frequency of discharge of presynaptic action potentials. This would explain how synaptic excitation of tonic cells decreases despite the fact that axotomy increases spontaneous activity in primary afferent neurons. <\/jats:p>","DOI":"10.1152\/jn.00296.2009","type":"journal-article","created":{"date-parts":[[2009,10,1]],"date-time":"2009-10-01T01:33:04Z","timestamp":1254360784000},"page":"3203-3215","source":"Crossref","is-referenced-by-count":43,"title":["Effects of Sciatic Nerve Axotomy on Excitatory Synaptic Transmission in Rat Substantia Gelatinosa"],"prefix":"10.1152","volume":"102","author":[{"given":"Yishen","family":"Chen","sequence":"first","affiliation":[{"name":"Departments of Pharmacology and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sridhar","family":"Balasubramanyan","sequence":"additional","affiliation":[{"name":"Departments of Pharmacology and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aaron Y.","family":"Lai","sequence":"additional","affiliation":[{"name":"Psychiatry, 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