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We also recorded from 8- and 9-day-old rats to further elucidate the occurrence and magnitude of LTP in neonates. With halothane anesthesia, all animals in each age group exhibited synaptic plasticity of the excitatory postsynaptic potential following high-frequency stimulation of the MPP. In 7-day-old rats, LTP was elicited in 40% of the animals and had an average magnitude of 143%. Long-term depression (LTD) alone (magnitude of 84%) was induced in 40% of the animals, while short-term potentiation (STP) alone (magnitude of 123%) was induced in 10%. STP followed by LTD was elicited in the remaining 10%. Data were similar for all ages combined. In addition, the N-methyl-d-aspartate (NMDA) antagonist ( R,S)-3-(2-carboxypiperazin-4-yl)propyl-1-phosphonic acid (CPP) blocked the occurrence of LTP at each age and doubled the percentage of animals expressing LTD alone for all ages combined. These results demonstrate that tetanic stimulation can elicit LTP or LTD at MPP synapses in 7-day-old rats, supporting our premise that at least a portion of the dentate gyrus is functional at this early age. <\/jats:p>","DOI":"10.1152\/jn.00307.2003","type":"journal-article","created":{"date-parts":[[2004,2,4]],"date-time":"2004-02-04T23:26:28Z","timestamp":1075937188000},"page":"613-622","source":"Crossref","is-referenced-by-count":7,"title":["In Vivo Recordings of Long-Term Potentiation and Long-Term Depression in the Dentate Gyrus of the Neonatal Rat"],"prefix":"10.1152","volume":"91","author":[{"given":"Michael P.","family":"O'Boyle","sequence":"first","affiliation":[{"name":"Department of Biology, The University of Texas at San Antonio, San Antonio, Texas 78249"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Viet","family":"Do","sequence":"additional","affiliation":[{"name":"Department of Biology, The University of Texas at San Antonio, San Antonio, Texas 78249"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian E.","family":"Derrick","sequence":"additional","affiliation":[{"name":"Department of Biology, The University of Texas at San Antonio, San Antonio, Texas 78249"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brenda J.","family":"Claiborne","sequence":"additional","affiliation":[{"name":"Department of Biology, The University of Texas at San Antonio, San Antonio, Texas 78249"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"REF1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(88)90582-3"},{"key":"REF2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(96)00130-8"},{"key":"REF3","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.1994.tb00567.x"},{"key":"REF4","doi-asserted-by":"publisher","DOI":"10.1002\/cne.901900107"},{"key":"REF5","unstructured":"Bear MF and Linden DJ. 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