{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T00:41:19Z","timestamp":1790383279629,"version":"4.1.0"},"reference-count":39,"publisher":"American Physiological Society","issue":"3","funder":[{"DOI":"10.13039\/100000062","name":"HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["R01-DK68098"],"award-info":[{"award-number":["R01-DK68098"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006668","name":"Oregon Health and Science University","doi-asserted-by":"publisher","award":["Circle of Giving"],"award-info":[{"award-number":["Circle of Giving"]}],"id":[{"id":"10.13039\/100006668","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.physiology.org"],"crossmark-restriction":true},"short-container-title":["Journal of Neurophysiology"],"published-print":{"date-parts":[[2025,9,1]]},"abstract":"<jats:p>\n                    This study reveals early pathological changes in the medial mammillary bodies of female 5XFAD\n                    <jats:sup>+<\/jats:sup>\n                    mice, an Alzheimer\u2019s disease model, with increased A\u03b2 and vGlut2 expression beginning at 2 mo. Electrophysiological recordings show that female MB neurons are in a hyperexcitable state, driven by enhanced persistent sodium and T-type calcium currents. These changes suggest that MB dysfunction may contribute to Papez circuit hyperexcitability in AD, highlighting a previously underexplored site of pathology in postmenopausal females.\n                  <\/jats:p>","DOI":"10.1152\/jn.00310.2025","type":"journal-article","created":{"date-parts":[[2025,8,6]],"date-time":"2025-08-06T14:30:41Z","timestamp":1754490641000},"page":"928-939","update-policy":"https:\/\/doi.org\/10.1152\/aps-crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["Early onset of hyperexcitability of medial mammillary body neurons in 5XFAD\n                    <sup>+<\/sup>\n                    mice\u2014an early target of Alzheimer\u2019s disease"],"prefix":"10.1152","volume":"134","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7504-2422","authenticated-orcid":false,"given":"Todd L.","family":"Stincic","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/009avj582","id-type":"ROR","asserted-by":"publisher"}],"name":"Oregon Health and Science University","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4988-8587","authenticated-orcid":false,"given":"Jian","family":"Qiu","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/009avj582","id-type":"ROR","asserted-by":"publisher"}],"name":"Oregon Health and Science University","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cole","family":"Martinson","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/009avj582","id-type":"ROR","asserted-by":"publisher"}],"name":"Oregon Health and Science University","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8633-2510","authenticated-orcid":false,"given":"Martin J.","family":"Kelly","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/009avj582","id-type":"ROR","asserted-by":"publisher"}],"name":"Oregon Health and Science University","place":["United States"]},{"name":"Oregon National Primate Research Center","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1841-4386","authenticated-orcid":false,"given":"Oline K.","family":"Ronnekleiv","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/009avj582","id-type":"ROR","asserted-by":"publisher"}],"name":"Oregon Health and Science University","place":["United States"]},{"name":"Oregon National Primate Research Center","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1016\/S0962-8924(98)01368-3"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0207885"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-32951-4"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2021.05.006"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1038\/nn.3606"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.00736"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2014.07.025"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2020.11.031"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1093\/alcalc\/agn103"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1016\/S0361-9230(98)00077-X"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.abq1019"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1038\/s42003-019-0599-8"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1202-06.2006"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1101\/pdb.prot099770"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.16246"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1210\/me.2014-1392"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1687-10.2010"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3229-06.2006"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0622-21.2021"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmet.2022.101645"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmet.2021.101218"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1113\/JP283378"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2016.08.046"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2014.07.050"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1523\/jneurosci.2358-07.2007"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2015.08.016"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1038\/nn.2149"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1177\/1533317515602548"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1992.68.4.1321"},{"key":"B30","volume":"3","author":"Lee CC","year":"2016","journal-title":"Neurotransmitter (Houst)"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2021.108712"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1007\/s00424-024-02980-7"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)80509-7"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2024.102436"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1016\/j.nlm.2018.06.004"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2015.07.087"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1038\/nature13548"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceca.2009.12.010"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M109.080069"}],"container-title":["Journal of Neurophysiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.physiology.org\/doi\/pdf\/10.1152\/jn.00310.2025","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,4]],"date-time":"2025-09-04T17:34:40Z","timestamp":1757007280000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.physiology.org\/doi\/10.1152\/jn.00310.2025"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,1]]},"references-count":39,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,9,1]]}},"alternative-id":["10.1152\/jn.00310.2025"],"URL":"https:\/\/doi.org\/10.1152\/jn.00310.2025","relation":{},"ISSN":["0022-3077","1522-1598"],"issn-type":[{"value":"0022-3077","type":"print"},{"value":"1522-1598","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9,1]]},"assertion":[{"value":"2025-06-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-07-03","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-07-29","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-04","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}