{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T19:13:09Z","timestamp":1787166789854,"version":"build-2736575974"},"reference-count":92,"publisher":"American Physiological Society","issue":"6","funder":[{"DOI":"10.13039\/100000050","name":"HHS | NIH | National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["HL166183"],"award-info":[{"award-number":["HL166183"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"HHS | NIH | National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["HL98602"],"award-info":[{"award-number":["HL98602"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.physiology.org"],"crossmark-restriction":true},"short-container-title":["Journal of Neurophysiology"],"published-print":{"date-parts":[[2025,12,1]]},"abstract":"<jats:p>\n                    Exposure to acute intermittent hypoxia (AIH) induced sustained increases in phrenic nerve activity (phrenic long-term facilitation, pLTF) that were associated with increased nucleus tractus solitarii (nTS) neuronal Ca\n                    <jats:sup>2+<\/jats:sup>\n                    and action potential discharge. nTS CaMKII activity was critical for pLTF development and AIH-induced increases in neuronal discharge. In contrast, nTS NMDA receptor (NMDAR) activation, but not CaMKII activity, was required for maintaining AIH-induced pLTF. Increased nTS neuronal activity, NMDAR activation, and CaMKII are critical for AIH-induced neuroplasticity in central cardiorespiratory output.\n                  <\/jats:p>","DOI":"10.1152\/jn.00325.2025","type":"journal-article","created":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T17:32:06Z","timestamp":1760981526000},"page":"1819-1836","update-policy":"https:\/\/doi.org\/10.1152\/aps-crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Acute intermittent hypoxia enhances nucleus of the solitary tract neuronal activity and requires NMDARs and CaMKII for phrenic long-term facilitation"],"prefix":"10.1152","volume":"134","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1886-5243","authenticated-orcid":false,"given":"Fateme","family":"Khodadadi-Mericle","sequence":"first","affiliation":[{"name":"University of Missouri","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4552-1021","authenticated-orcid":false,"given":"Eileen M.","family":"Hasser","sequence":"additional","affiliation":[{"name":"University of Missouri","place":["United States"]},{"name":"University of Missouri","place":["United States"]},{"name":"University of Missouri","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3269-0184","authenticated-orcid":false,"given":"David D.","family":"Kline","sequence":"additional","affiliation":[{"name":"University of Missouri","place":["United States"]},{"name":"University of Missouri","place":["United States"]},{"name":"University of Missouri","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4419-5692-7_45"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.2001.90.6.2466"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2023.1120341"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2015.08.011"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.22-14-06239.2002"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00904.2013"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1016\/j.resp.2017.10.005"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1113\/expphysiol.2006.035758"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2010.190454"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00896.2005"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2009.178053"},{"key":"B12","first-page":"341","volume":"57","author":"Sokolowska B","year":"2006","journal-title":"J Physiol Pharmacol"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1997.sp021947"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00060.2012"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1113\/JP275001"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.21-14-05381.2001"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1016\/j.resp.2008.04.013"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.1993.265.2.H770"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1016\/j.resp.2010.04.015"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00143.2006"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchemneu.2009.03.004"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.109.146407"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1995.74.4.1529"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00830.2010"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1016\/s0034-5687(00)00126-2"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7793.2001.0483f.x"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00381.2014"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2025.115380"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1994.sp020229"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7793.1999.567ae.x"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2007.129031"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(92)91537-o"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.01205.2004"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.2000.278.2.R520"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9861(19981207)402:1<75::AID-CNE6>3.0.CO;2-9"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1016\/0165-6147(90)90116-p"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1681.2002.03662.x"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00601.2002"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2005.09.017"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00185.2004"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1038\/361031a0"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a005710"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1126\/science.285.5435.1870"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1016\/0028-3908(89)90076-2"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.1999.0731181.x"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2013.07.030"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2007.01.011"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M116.734822"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M303576200"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1038\/emboj.2011.482"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1038\/362640a0"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1250-11.2011"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.14-03-01123.1994"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4946-06.2007"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1113\/JP285854"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00764.2013"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00244.2018"},{"key":"B58","volume-title":"The Rat Brain in Stereotaxic Coordinates","author":"Paxinos G","year":"2013"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00319.2019"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00135.2019"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1113\/JP274620"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2141-17.2017"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00019.2021"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(92)90458-l"},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.4137\/JEN.S39887"},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00249.2005"},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.1016\/s0034-5687(98)00026-7"},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1734109100"},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00143.2007"},{"key":"B70","doi-asserted-by":"publisher","DOI":"10.1016\/s0034-5687(97)00087-x"},{"key":"B71","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(92)90781-2"},{"key":"B72","doi-asserted-by":"publisher","DOI":"10.1007\/s00424-008-0571-9"},{"key":"B73","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0992-17.2017"},{"key":"B74","doi-asserted-by":"publisher","DOI":"10.1002\/cne.903370205"},{"key":"B75","doi-asserted-by":"publisher","DOI":"10.1002\/cne.903470106"},{"key":"B76","doi-asserted-by":"publisher","DOI":"10.1016\/s0306-4522(98)00530-2"},{"key":"B77","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1998.84.3.853"},{"key":"B78","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2013.258103"},{"key":"B79","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1999.81.6.3034"},{"key":"B80","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.01274.2006"},{"key":"B81","doi-asserted-by":"publisher","DOI":"10.1016\/j.resp.2008.05.016"},{"key":"B82","doi-asserted-by":"publisher","DOI":"10.14814\/phy2.13158"},{"key":"B83","doi-asserted-by":"publisher","DOI":"10.1161\/01.hyp.30.6.1499"},{"key":"B84","doi-asserted-by":"publisher","DOI":"10.1038\/s41583-022-00624-2"},{"key":"B85","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2021.108616"},{"key":"B86","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2024.114866"},{"key":"B87","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2402783121"},{"key":"B88","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.RA120.014062"},{"key":"B89","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2012.03474.x"},{"key":"B90","first-page":"365","volume":"66","author":"Mao LM","year":"2014","journal-title":"Sheng Li Xue Bao"},{"key":"B91","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M111.323915"},{"key":"B92","doi-asserted-by":"publisher","DOI":"10.1093\/function\/zqad041"}],"container-title":["Journal of Neurophysiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.physiology.org\/doi\/pdf\/10.1152\/jn.00325.2025","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,19]],"date-time":"2025-11-19T19:06:35Z","timestamp":1763579195000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.physiology.org\/doi\/10.1152\/jn.00325.2025"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,1]]},"references-count":92,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,12,1]]}},"alternative-id":["10.1152\/jn.00325.2025"],"URL":"https:\/\/doi.org\/10.1152\/jn.00325.2025","relation":{},"ISSN":["0022-3077","1522-1598"],"issn-type":[{"value":"0022-3077","type":"print"},{"value":"1522-1598","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,1]]},"assertion":[{"value":"2025-06-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-07-20","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-14","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-19","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}