{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T10:15:22Z","timestamp":1771064122396,"version":"3.50.1"},"reference-count":51,"publisher":"American Physiological Society","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Neurophysiology"],"published-print":{"date-parts":[[2014,6,15]]},"abstract":"<jats:p> Synaptic transmission throughout most of the CNS is steeply dependent on presynaptic calcium influx through the voltage-gated calcium channels Ca<jats:sub>v<\/jats:sub>2.1\u2013Ca<jats:sub>v<\/jats:sub>2.3. In addition to triggering exocytosis, this calcium influx also recruits short-term synaptic plasticity. During the complex patterns of presynaptic activity that occur in vivo, several forms of plasticity combine to generate a synaptic output that is dynamic, in which the size of a given excitatory postsynaptic potential (EPSP) in response to a given spike depends on the short-term history of presynaptic activity. It remains unclear whether the different Ca<jats:sub>v<\/jats:sub>2 channels play distinct roles in defining these synaptic dynamics and, if so, under what conditions different Ca<jats:sub>v<\/jats:sub>2 family members most effectively determine synaptic output. We examined these questions by measuring the effects of calcium channel-selective toxins on synaptic transmission at the Schaffer collateral synapse in hippocampal slices from adult mice in response to both low-frequency stimulation and complex stimulus trains derived from in vivo recordings. Blockade of Ca<jats:sub>v<\/jats:sub>2.1 had a greater inhibitory effect on synaptic transmission during low-frequency components of the stimulus train than on synaptic transmission during high-frequency components of the train, indicating that Ca<jats:sub>v<\/jats:sub>2.1 had a greater fractional contribution to synaptic transmission at low frequencies than at high frequencies. Relative to Ca<jats:sub>v<\/jats:sub>2.1, Ca<jats:sub>v<\/jats:sub>2.2 had a disproportionately reduced contribution to synaptic transmission at frequencies &gt;20 Hz, while Ca<jats:sub>v<\/jats:sub>2.3 had a disproportionately increased contribution to synaptic transmission at frequencies &gt;1 Hz. These activity-dependent effects of different Ca<jats:sub>v<\/jats:sub>2 family members shape the filtering characteristics of GABA<jats:sub>B<\/jats:sub> receptor-mediated presynaptic inhibition. Thus different Ca<jats:sub>v<\/jats:sub>2 channels vary in their coupling to synaptic transmission over different frequency ranges, with consequences for the frequency tuning of both synaptic dynamics and presynaptic neuromodulation. <\/jats:p>","DOI":"10.1152\/jn.00335.2013","type":"journal-article","created":{"date-parts":[[2014,2,13]],"date-time":"2014-02-13T06:40:52Z","timestamp":1392273652000},"page":"2404-2413","source":"Crossref","is-referenced-by-count":20,"title":["Distinct roles for Ca<sub>v<\/sub>2.1\u20132.3 in activity-dependent synaptic dynamics"],"prefix":"10.1152","volume":"111","author":[{"given":"Ulises M.","family":"Ricoy","sequence":"first","affiliation":[{"name":"Department of Behavioral Neuroscience, Oregon Health and Science University, Portland, Oregon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew E.","family":"Frerking","sequence":"additional","affiliation":[{"name":"Department of Behavioral Neuroscience, Oregon Health and Science 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