{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T16:56:13Z","timestamp":1790528173103,"version":"4.1.0"},"reference-count":49,"publisher":"American Physiological Society","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Neurophysiology"],"published-print":{"date-parts":[[2012,10,15]]},"abstract":"<jats:p> Most studies of the mouse hindlimb locomotor network have used neonatal (P0\u20135) mice. In this study, we examine the postnatal development of intrinsic properties and serotonergic modulation of intersegmental commissural interneurons (CINs) from the neonatal period (P0\u20133) to the time the animals bear weight (P8\u201310) and begin to show adult walking (P14\u201316). CINs show an increase in excitability with age, associated with a decrease in action potential halfwidth and appearance of a fast component to the afterhyperpolarization at P14\u201316. Serotonin (5-HT) depolarizes and increases the excitability of most CINs at all ages. The major developmental difference is that serotonin can induce plateau potential capability in P14\u201316 CINs, but not at younger ages. These plateau potentials are abolished by nifedipine, suggesting that they are mediated by an L-type calcium current, I<jats:sub>Ca(L)<\/jats:sub>. Voltage-clamp analysis demonstrates that 5-HT increases a nifedipine-sensitive voltage-activated calcium current, I<jats:sub>Ca(V)<\/jats:sub>, in P14\u201316 CINs but does not increase I<jats:sub>Ca(V)<\/jats:sub> in P8\u201310 CINs. These results, together with earlier work on 5-HT effects on neonatal CINs, suggest that 5-HT increases the excitability of CINs at all ages studied, but by opposite effects on calcium currents, decreasing N- and P\/Q-type calcium currents and, indirectly, calcium-activated potassium current, at P0\u20133 but increasing I<jats:sub>Ca(L)<\/jats:sub> at P14\u201316. <\/jats:p>","DOI":"10.1152\/jn.00336.2012","type":"journal-article","created":{"date-parts":[[2012,7,26]],"date-time":"2012-07-26T04:25:50Z","timestamp":1343276750000},"page":"2191-2202","source":"Crossref","is-referenced-by-count":46,"title":["Postnatal emergence of serotonin-induced plateau potentials in commissural interneurons of the mouse spinal cord"],"prefix":"10.1152","volume":"108","author":[{"given":"Matthew D.","family":"Abbinanti","sequence":"first","affiliation":[{"name":"Department of Neurobiology and Behavior, Cornell University, Ithaca, New 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