{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T04:32:41Z","timestamp":1791261161954,"version":"4.1.0"},"reference-count":36,"publisher":"American Physiological Society","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Neurophysiology"],"published-print":{"date-parts":[[2013,10,15]]},"abstract":"<jats:p>High-frequency oscillations (HFO; gamma: 40\u2013100 Hz, ripples: 100\u2013200 Hz, and fast ripples: 250\u2013500 Hz) have been widely studied in health and disease. These phenomena may serve as biomarkers for epileptic brain; however, a means of differentiating between pathological and normal physiological HFO is essential. We categorized task-induced physiological HFO during periods of HFO induced by a visual or motor task by measuring frequency, duration, and spectral amplitude of each event in single trial time-frequency spectra and compared them to pathological HFO similarly measured. Pathological HFO had higher mean spectral amplitude, longer mean duration, and lower mean frequency than physiological-induced HFO. In individual patients, support vector machine analysis correctly classified pathological HFO with sensitivities ranging from 70\u201398% and specificities &gt;90% in all but one patient. In this patient, infrequent high-amplitude HFO were observed in the motor cortex just before movement onset in the motor task. This finding raises the possibility that in epileptic brain physiological-induced gamma can assume higher spectral amplitudes similar to those seen in pathologic HFO. This method if automated and validated could provide a step towards differentiating physiological HFO from pathological HFO and improving localization of epileptogenic brain.<\/jats:p>","DOI":"10.1152\/jn.00341.2013","type":"journal-article","created":{"date-parts":[[2013,8,7]],"date-time":"2013-08-07T21:58:49Z","timestamp":1375912729000},"page":"1958-1964","source":"Crossref","is-referenced-by-count":219,"title":["Pathological and physiological high-frequency oscillations in focal human epilepsy"],"prefix":"10.1152","volume":"110","author":[{"given":"Andrew","family":"Matsumoto","sequence":"first","affiliation":[{"name":"Department of Neurology, Mayo Systems Electrophysiology Laboratory, Mayo Clinic, Rochester, Minnesota; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin H.","family":"Brinkmann","sequence":"additional","affiliation":[{"name":"Department of Neurology, Mayo Systems Electrophysiology Laboratory, Mayo Clinic, Rochester, Minnesota; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Matthew Stead","sequence":"additional","affiliation":[{"name":"Department of Neurology, Mayo Systems Electrophysiology Laboratory, Mayo Clinic, Rochester, Minnesota; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Matsumoto","sequence":"additional","affiliation":[{"name":"Department of Neurology, Mayo Systems Electrophysiology Laboratory, Mayo Clinic, Rochester, Minnesota; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michal T.","family":"Kucewicz","sequence":"additional","affiliation":[{"name":"Department of Neurology, Mayo Systems Electrophysiology Laboratory, Mayo Clinic, Rochester, Minnesota; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W. Richard","family":"Marsh","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Mayo Systems Electrophysiology Laboratory, Mayo Clinic, Rochester, Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederic","family":"Meyer","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Mayo Systems Electrophysiology Laboratory, Mayo Clinic, Rochester, Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory","family":"Worrell","sequence":"additional","affiliation":[{"name":"Department of Neurology, Mayo Systems Electrophysiology Laboratory, Mayo Clinic, Rochester, Minnesota; and"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awn103"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2003.045674"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awr212"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2010.02896.x"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1097\/WCO.0b013e3283373ac8"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-1063(1999)9:2<137::AID-HIPO5>3.0.CO;2-0"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1157.1999.tb02065.x"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.22-05-02012.2002"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2007.01287.x"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneumeth.2009.03.022"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1126\/science.1589772"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1016\/j.pneurobio.2012.02.004"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1126\/science.1128115"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awp277"},{"key":"B14a","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpsycho.2010.10.013"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2008.01917.x"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.86.5.1698"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1016\/j.tics.2010.01.005"},{"key":"B18","volume-title":"International Affective Picture System (IAPS): Technical Manual and Affective Ratings.","author":"Lang PJ","year":"1997"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5049-09.2010"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awt159"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1898-08.2008"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.21233"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awp222"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2007.01225.x"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.17-02-00722.1997"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00327.2010"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awm149"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneumeth.2006.12.004"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2012.03721.x"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.3389\/fnhum.2010.00184"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.2217\/bmm.11.74"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awn006"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awh149"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1016\/j.pneurobio.2012.02.006"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.15-01-00030.1995"}],"container-title":["Journal of Neurophysiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.physiology.org\/doi\/pdf\/10.1152\/jn.00341.2013","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,9]],"date-time":"2019-09-09T02:50:00Z","timestamp":1567997400000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.physiology.org\/doi\/10.1152\/jn.00341.2013"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,10,15]]},"references-count":36,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2013,10,15]]}},"alternative-id":["10.1152\/jn.00341.2013"],"URL":"https:\/\/doi.org\/10.1152\/jn.00341.2013","relation":{},"ISSN":["0022-3077","1522-1598"],"issn-type":[{"value":"0022-3077","type":"print"},{"value":"1522-1598","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,10,15]]}}}