{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T23:34:07Z","timestamp":1785454447763,"version":"3.56.0"},"reference-count":29,"publisher":"American Physiological Society","issue":"4","funder":[{"DOI":"10.13039\/100006955","name":"Office of Extramural Research, National Institutes of Health (OER)","doi-asserted-by":"publisher","award":["DC012528"],"award-info":[{"award-number":["DC012528"]}],"id":[{"id":"10.13039\/100006955","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Neurophysiology"],"published-print":{"date-parts":[[2016,10,1]]},"abstract":"<jats:p>Migraine is associated with enhanced motion sickness susceptibility and can cause episodic vertigo [vestibular migraine (VM)], but the mechanisms relating migraine to these vestibular symptoms remain uncertain. We tested the hypothesis that the central integration of rotational cues (from the semicircular canals) and gravitational cues (from the otolith organs) is abnormal in migraine patients. A postrotational tilt paradigm generated a conflict between canal cues (which indicate the head is rotating) and otolith cues (which indicate the head is tilted and stationary), and eye movements were measured to quantify two behaviors that are thought to minimize this conflict: suppression and reorientation of the central angular velocity signal, evidenced by attenuation (\u201cdumping\u201d) of the vestibuloocular reflex and shifting of the rotational axis of the vestibuloocular reflex toward the earth vertical. We found that normal and migraine subjects, but not VM patients, displayed an inverse correlation between the extent of dumping and the size of the axis shift such that the net \u201cconflict resolution\u201d mediated through these two mechanisms approached an optimal value and that the residual sensory conflict in VM patients (but not migraine or normal subjects) correlated with motion sickness susceptibility. Our findings suggest that the brain normally controls the dynamic and spatial characteristics of central vestibular signals to minimize intravestibular sensory conflict and that this process is disrupted in VM, which may be responsible for the enhance motion intolerance and episodic vertigo that characterize this disorder.<\/jats:p>","DOI":"10.1152\/jn.00345.2016","type":"journal-article","created":{"date-parts":[[2016,7,7]],"date-time":"2016-07-07T02:09:00Z","timestamp":1467857340000},"page":"1586-1591","source":"Crossref","is-referenced-by-count":31,"title":["Contribution of intravestibular sensory conflict to motion sickness and dizziness in migraine disorders"],"prefix":"10.1152","volume":"116","author":[{"given":"Joanne","family":"Wang","sequence":"first","affiliation":[{"name":"Case Western University Medical School, Cleveland, Ohio;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard F.","family":"Lewis","sequence":"additional","affiliation":[{"name":"Jenks Vestibular Physiology Laboratory, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts;"},{"name":"Department of Otology and Laryngology, Harvard Medical School, Boston, Massachusetts; and"},{"name":"Department of Neurology, Harvard Medical School, Boston, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1994.71.3.1222"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1007\/s12311-009-0147-z"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00058.2002"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1097\/MAO.0b013e3181b4e780"},{"key":"B5","doi-asserted-by":"crossref","first-page":"163","DOI":"10.3233\/VES-1999-9303","volume":"9","author":"Cohen B","year":"1999","journal-title":"J Vestib Res"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2011.12.001"},{"key":"B7","first-page":"859","volume":"61","author":"Engelken EJ","year":"1990","journal-title":"Aviat Space Environ Med"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(13)70107-8"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1016\/S0361-9230(98)00091-4"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1007\/s11916-014-0458-8"},{"key":"B11","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1111\/j.1468-2982.2004.00641.x","volume":"24","author":"Headache Classification Subcommittee of the International Headache Society","year":"2004","journal-title":"Cephalalgia"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-009-5435-5"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/107.4.1123"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1007\/s00221-011-2568-4"},{"key":"B15","doi-asserted-by":"crossref","first-page":"167","DOI":"10.3233\/VES-2012-0453","volume":"22","author":"Lempert T","year":"2012","journal-title":"J Vestib Res"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1002\/lary.21723"},{"key":"B17","doi-asserted-by":"crossref","first-page":"323","DOI":"10.3233\/VES-2011-0422","volume":"21","author":"Lewis RF","year":"2011","journal-title":"J Vestib Res"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3931-07.2007"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.1970.50.1.1"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.56.4.436"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1139\/y90-044"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1007\/s00221-014-3973-2"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1159\/000255440"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000000496"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1126\/science.3871968"},{"key":"B26","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1152\/ajplegacy.1956.185.3.617","volume":"185","author":"Wang SC","year":"1956","journal-title":"Am J Physiol"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1007\/s10162-016-0559-7"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1016\/S0361-9230(98)00092-6"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1152\/jn.2000.84.4.2001"}],"container-title":["Journal of Neurophysiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.physiology.org\/doi\/pdf\/10.1152\/jn.00345.2016","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,2]],"date-time":"2022-07-02T20:19:32Z","timestamp":1656793172000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.physiology.org\/doi\/10.1152\/jn.00345.2016"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,10,1]]},"references-count":29,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2016,10,1]]}},"alternative-id":["10.1152\/jn.00345.2016"],"URL":"https:\/\/doi.org\/10.1152\/jn.00345.2016","relation":{},"ISSN":["0022-3077","1522-1598"],"issn-type":[{"value":"0022-3077","type":"print"},{"value":"1522-1598","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,10,1]]}}}