{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T22:42:34Z","timestamp":1759963354427},"reference-count":48,"publisher":"American Physiological Society","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Neurophysiology"],"published-print":{"date-parts":[[2002,12,1]]},"abstract":"<jats:p> Carotid body chemoreceptors transduce a decrease in arterial oxygen tension into an increase in spiking activity on the sinus nerve, and this response increases with postnatal age over the first week or two of life. Previous work from our laboratory has suggested a major role of axonal Na<jats:sup>+<\/jats:sup> channels in the initiation of afferent spiking activity. Using RT\u2013PCR of the petrosal ganglia we identified Na<jats:sup>+<\/jats:sup> channel TTX-S isoforms Na<jats:sub>v<\/jats:sub>1.1, Na<jats:sub>v<\/jats:sub>1.6, and Na<jats:sub>v<\/jats:sub>1.7 and the TTX-resistant (TTX-R) isoforms Na<jats:sub>v<\/jats:sub>1.8 and Na<jats:sub>v<\/jats:sub>1.9 at high levels. Electrophysiologic recordings (at 3 ages: 3 days, 9 days, 18\u201320 days) of neurons that project to the carotid body exhibited predominantly fast-inactivating sodium currents, with a bimodal recovery from inactivation at \u221280 mV (fast component \u223c 8 ms; slow component \u223c90 ms). Developmental age had little effect with no change in peak current density (approximately 1.4 nA\/pF) and was associated with a slight, but significant increase in the speed of recovery from inactivation at \u2212140 and \u2212120 mV but not at other potentials. Assuming that the same Na<jats:sup>+<\/jats:sup> channel complement is present at the nerve terminal as at the soma, the association of a sensory modality (chemoreception) with a relatively uniform Na<jats:sup>+<\/jats:sup> channel profile suggests that the rapid kinetics of TTX-S channels may be essential for some aspects of chemoreceptor function beyond mediating simple axonal conduction. <\/jats:p>","DOI":"10.1152\/jn.00350.2002","type":"journal-article","created":{"date-parts":[[2006,5,31]],"date-time":"2006-05-31T06:06:00Z","timestamp":1149055560000},"page":"2993-3002","source":"Crossref","is-referenced-by-count":21,"title":["Characterization and Developmental Changes of Na<sup>+<\/sup>Currents of Petrosal Neurons With Projections to the Carotid Body"],"prefix":"10.1152","volume":"88","author":[{"given":"Theodore R.","family":"Cummins","sequence":"first","affiliation":[{"name":"Department of Neurology and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sulayman 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