{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T11:00:42Z","timestamp":1781780442281,"version":"3.54.5"},"reference-count":71,"publisher":"American Physiological Society","issue":"6","funder":[{"DOI":"10.13039\/100000025","name":"HHS | NIH | National Institute of Mental Health","doi-asserted-by":"publisher","award":["MH-118563-01"],"award-info":[{"award-number":["MH-118563-01"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000025","name":"HHS | NIH | National Institute of Mental Health","doi-asserted-by":"publisher","award":["MH-118563-04-S1"],"award-info":[{"award-number":["MH-118563-04-S1"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"HHS | NIH | National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["T32- NS061788"],"award-info":[{"award-number":["T32- NS061788"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.physiology.org"],"crossmark-restriction":true},"short-container-title":["Journal of Neurophysiology"],"published-print":{"date-parts":[[2025,12,1]]},"abstract":"<jats:p>\n                    The hippocampus is hyperactive in a mouse model for Rett syndrome, and such atypically heightened activity propagates to the medial prefrontal cortex (mPFC) through a monosynaptic projection, resulting in altered mPFC activity and social memory deficits. Here, we used fiber photometry of population Ca\n                    <jats:sup>2+<\/jats:sup>\n                    signals as surrogates of neuronal activity, and show that atypically heightened inhibition from pyramidal neuron (PYR)-targeting GABAergic parvalbumin interneurons, and impaired PYR activity in the mPFC of Rett mice during social interactions, driving their deficit in social memory.\n                  <\/jats:p>","DOI":"10.1152\/jn.00360.2025","type":"journal-article","created":{"date-parts":[[2025,11,10]],"date-time":"2025-11-10T16:52:51Z","timestamp":1762793571000},"page":"2070-2085","update-policy":"https:\/\/doi.org\/10.1152\/aps-crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Altered activity of mPFC pyramidal neurons and parvalbumin-expressing interneurons during social interactions in a\n                    <i>Mecp2<\/i>\n                    mouse model for Rett syndrome"],"prefix":"10.1152","volume":"134","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1871-4189","authenticated-orcid":false,"given":"Destynie","family":"Medeiros","sequence":"first","affiliation":[{"name":"University of Alabama at Birmingham","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-0941-9289","authenticated-orcid":false,"given":"Likhitha","family":"Polepalli","sequence":"additional","affiliation":[{"name":"University of Alabama at Birmingham","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3232-8986","authenticated-orcid":false,"given":"Wei","family":"Li","sequence":"additional","affiliation":[{"name":"University of Alabama at Birmingham","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6085-5527","authenticated-orcid":false,"given":"Lucas","family":"Pozzo-Miller","sequence":"additional","affiliation":[{"name":"University of Alabama at Birmingham","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2017.213"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-79109-0"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2007.03.051"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2015.11.036"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1038\/s41380-021-01430-5"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-14740-z"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2018.02.026"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2014.05.017"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.3389\/fncir.2017.00041"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1002\/hipo.22797"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1016\/j.neures.2017.05.007"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2018.01.019"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1007\/s00221-018-5187-5"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1038\/nature13028"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-06501-w"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaf7003"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.44182"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0307-16.2016"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2018.08.043"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1038\/nature10360"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2020.100894"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2007.10.001"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1177\/0883073888003001s02"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1038\/s41684-022-00919-y"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1177\/08830738050200090901"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2005.10.037"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410140412"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3181d6b852"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2788.2011.01404.x"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1016\/j.pediatrneurol.2024.01.004"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1038\/13810"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2019.10.004"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1038\/85906"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00800.2010"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1002\/hipo.22360"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1517244113"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2009.12.018"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1016\/j.eplepsyres.2018.01.015"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1002\/hipo.20389"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.3389\/fncir.2013.00042"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1016\/j.resp.2009.04.017"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0506071102"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2012.12.004"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhv002"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1616-12.2012"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4673-14.2015"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0378-18.2018"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.55267"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1038\/s41593-018-0073-9"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.3389\/fnbeh.2016.00151"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.3389\/fninf.2015.00007"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.3791\/60278"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.3770"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-1848.2004.00076.x"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-183X.2004.00071.x"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1002\/0471142301.ns0826s56"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/dds406"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abf7467"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-023-05828-9"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.aay4073"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aah6733"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-31578-9"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abo4884"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.3389\/fnmol.2013.00002"},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2024.113850"},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2014.12.014"},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-024-52277-z"},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddh142"},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.12727"},{"key":"B70","doi-asserted-by":"publisher","DOI":"10.1186\/s12915-018-0480-0"},{"key":"B71","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.1209"}],"container-title":["Journal of Neurophysiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.physiology.org\/doi\/pdf\/10.1152\/jn.00360.2025","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,15]],"date-time":"2025-12-15T17:02:52Z","timestamp":1765818172000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.physiology.org\/doi\/10.1152\/jn.00360.2025"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,1]]},"references-count":71,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,12,1]]}},"alternative-id":["10.1152\/jn.00360.2025"],"URL":"https:\/\/doi.org\/10.1152\/jn.00360.2025","relation":{},"ISSN":["0022-3077","1522-1598"],"issn-type":[{"value":"0022-3077","type":"print"},{"value":"1522-1598","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,1]]},"assertion":[{"value":"2025-07-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-11","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-02","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-15","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}