{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T11:59:21Z","timestamp":1740139161700,"version":"3.37.3"},"reference-count":38,"publisher":"American Physiological Society","issue":"4","funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science (JSPS)","doi-asserted-by":"publisher","award":["KAKENHI 24659916","KAKENHI 25293422","KAKENHI 26861799","KAKENHI 15K15759"],"award-info":[{"award-number":["KAKENHI 24659916","KAKENHI 25293422","KAKENHI 26861799","KAKENHI 15K15759"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Neurophysiology"],"published-print":{"date-parts":[[2017,10,1]]},"abstract":"<jats:p> The impairment of orofacial motor function during orthodontic treatment needs to be addressed, because most orthodontic patients experience pain and motor excitability would be affected by pain. In the present study, the temporal alteration of the jaw-opening reflex excitability was investigated to determine if orthodontic treatment affects orofacial motor function. The excitability of jaw-opening reflex evoked by electrical stimulation on the gingiva and recorded bilaterally in the anterior digastric muscles was evaluated at 1 (D1), 3 (D3), and 7 days (D7) after orthodontic force application to the teeth of right side; morphological features (e.g., osteoclast genesis and tooth movement) were also evaluated. To clarify the underlying mechanism of orthodontic treatment-induced alteration of orofacial motor excitability, analgesics were administrated for 1 day. At D1 and D3, orthodontic treatment significantly decreased the threshold for inducing the jaw-opening reflex but significantly increased the threshold at D7. Other parameters of the jaw-opening reflex were also evaluated (e.g., latency, duration and area under the curve of anterior digastric muscles activity), and only the latency of the D1 group was significantly different from that of the other groups. Temporal alteration of the jaw-opening reflex excitability was significantly correlated with changes in morphological features. Aspirin (300 mg\u00b7kg<jats:sup>\u22121<\/jats:sup>\u00b7day<jats:sup>\u22121<\/jats:sup>) significantly increased the threshold for inducing the jaw-opening reflex, whereas a lower dose (75\u2013150 mg\u00b7kg<jats:sup>\u22121<\/jats:sup>\u00b7day<jats:sup>\u22121<\/jats:sup>) of aspirin or acetaminophen (300 mg\u00b7kg<jats:sup>\u22121<\/jats:sup>\u00b7day<jats:sup>\u22121<\/jats:sup>) failed to alter the jaw-opening reflex excitability. These results suggest that an increase of the jaw-opening reflex excitability can be induced acutely by orthodontic treatment, possibly through the cyclooxygenase activation. <\/jats:p><jats:p> NEW &amp; NOTEWORTHY It is well known that motor function is affected by pain, but the effect of orthodontic treatment-related pain on the trigeminal motor excitability has not been fully understood. We found that, during orthodontic treatment, trigeminal motor excitability is acutely increased and then decreased in a week. Because alteration of trigeminal motor function can be evaluated quantitatively by jaw-opening reflex excitability, the present animal model may be useful to search for alternative approaches to attenuate orthodontic pain. <\/jats:p>","DOI":"10.1152\/jn.00379.2017","type":"journal-article","created":{"date-parts":[[2017,7,19]],"date-time":"2017-07-19T21:10:20Z","timestamp":1500498620000},"page":"2289-2295","source":"Crossref","is-referenced-by-count":1,"title":["Orthodontic treatment-induced temporal alteration of jaw-opening reflex excitability"],"prefix":"10.1152","volume":"118","author":[{"given":"Au","family":"Sasaki","sequence":"first","affiliation":[{"name":"Division of Orthodontics, Department of Human Development and Fostering, Meikai University School of Dentistry, Sakado, Saitama, Japan;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naoya","family":"Hasegawa","sequence":"additional","affiliation":[{"name":"Division of Orthodontics, Department of Human Development and Fostering, Meikai University School of Dentistry, Sakado, Saitama, Japan;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazunori","family":"Adachi","sequence":"additional","affiliation":[{"name":"Division of Pharmacology, Department of Diagnostics and Therapeutics Science, Meikai University School of Dentistry, Sakado, Saitama, Japan; and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Sakagami","sequence":"additional","affiliation":[{"name":"Meikai University Research Institute of Odontology, Saitama, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naoto","family":"Suda","sequence":"additional","affiliation":[{"name":"Division of Orthodontics, Department of Human Development and Fostering, Meikai University School of Dentistry, Sakado, Saitama, Japan;"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1186\/1744-8069-6-59"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpain.2006.01.444"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajodo.2004.12.027"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1016\/S1353-8020(09)70828-4"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1054\/jpai.2001.26173"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(90)90354-7"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1016\/0166-2236(92)90019-5"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1097\/00008877-199000160-00001"},{"key":"B9","first-page":"959","volume-title":"Goodman & Gilman\u2019s The Pharmacological Basis of Therapeutics","author":"Grosser T","year":"2011","edition":"12"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1177\/0022034515586543"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1177\/0022034516641276"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2006.03.010"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1126\/science.1127233"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1186\/1744-8069-8-23"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.2319\/121308-632R.1"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2005.02.003"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1093\/ejo\/12.3.320"},{"key":"B18","first-page":"117","volume-title":"Orofacial Pain: From Basic Science to Clinical Management","author":"Lund JP","year":"2008","edition":"2"},{"key":"B19","first-page":"109","volume-title":"Orofacial Pain: From Basic Science to Clinical Management","author":"Lund JP","year":"2008","edition":"2"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1111\/ejn.12562"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1093\/ejo\/cjq068"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1016\/0889-5406(89)90228-X"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresbull.2005.06.013"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajodo.2007.05.020"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.2174\/1568026054367638"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1177\/0022034514536730"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.2319\/121108-629R.1"},{"key":"B28","first-page":"8","volume":"71","author":"Simmons KE","year":"1992","journal-title":"J Indiana Dent Assoc"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.11607\/ofph.1336"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1002\/cne.23753"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1093\/ejo\/cjt053"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1186\/1744-8069-6-89"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2011.09.003"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3292-05.2006"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1007\/BF00427414"},{"key":"B36","first-page":"107","volume":"11","author":"Wilson S","year":"1989","journal-title":"Pediatr Dent"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1093\/ejo\/cjp078"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.5665\/sleep.2388"}],"container-title":["Journal of Neurophysiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.physiology.org\/doi\/pdf\/10.1152\/jn.00379.2017","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,9]],"date-time":"2019-09-09T02:13:38Z","timestamp":1567995218000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.physiology.org\/doi\/10.1152\/jn.00379.2017"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,10,1]]},"references-count":38,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2017,10,1]]}},"alternative-id":["10.1152\/jn.00379.2017"],"URL":"https:\/\/doi.org\/10.1152\/jn.00379.2017","relation":{},"ISSN":["0022-3077","1522-1598"],"issn-type":[{"type":"print","value":"0022-3077"},{"type":"electronic","value":"1522-1598"}],"subject":[],"published":{"date-parts":[[2017,10,1]]}}}