{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T15:28:23Z","timestamp":1779204503822,"version":"3.51.4"},"reference-count":71,"publisher":"American Physiological Society","issue":"6","funder":[{"name":"Nebraska Tobacco Settlement Biomedical Research Foundation, TAJ, timothy.jones@unl.edu","award":["na"],"award-info":[{"award-number":["na"]}]},{"name":"Dept of Special Education and Communication Disorders, Univ of Nebraska, TAJ, timothy.jones@unl.edu","award":["na"],"award-info":[{"award-number":["na"]}]},{"name":"American Academy of Audiology Foundation, CL, clee6637@gmail.com","award":["na"],"award-info":[{"award-number":["na"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Neurophysiology"],"published-print":{"date-parts":[[2017,12,1]]},"abstract":"<jats:p>The precise role and mechanisms underlying efferent modulation of peripheral vestibular afferent function are not well understood in mammals. Clarifying the details of efferent action may lead to new strategies for clinical management of debilitating disturbances in vestibular and balance function. Recent evidence in turtle indicates that efferent modulation of M-currents is likely one mechanism for modifying afferent discharge. M-currents depend in part on KCNQ potassium conductances (Kv7), which can be adjusted through efferent activation of M1, M3, and\/or M5 muscarinic acetylcholine receptors (mAChRs). How KCNQ channels and altered M-currents affect vestibular afferent function in vivo is unclear, and whether such a mechanism operates in mammals is unknown. In this study we used the KCNQ antagonist XE991 and the KCNQ activator retigabine in anesthetized mice to evaluate the effects of M-current modulation on peripheral vestibular responses to transient head motion. At low doses of XE991, responses were modestly enhanced, becoming larger in amplitude and shorter in latency. Higher doses of XE991 produced transient response enhancement, followed by steady-state suppression where latencies and thresholds increased and amplitudes decreased. Retigabine produced opposite effects. Auditory function was also impacted, based on results of companion auditory brain stem response testing. We propose that closure of KCNQ channels transforms vestibular afferent behavior by suppressing responses to transient high-frequency stimuli while simultaneously enhancing responses to sustained low-frequency stimulation. Our results clearly demonstrate that KCNQ channels are critical for normal mammalian vestibular function and suggest that efferent action may utilize these mechanisms to modulate the dynamic characteristics and gain of vestibular afferent responses.<\/jats:p><jats:p>NEW &amp; NOTEWORTHY The role of calyceal KCNQ channels and associated M-current in normal mammalian vestibular function is unknown. Our results show that calyceal KCNQ channels are critical for normal vestibular function in the intact mammal. The findings provide evidence that efferent modulation of M-currents may act normally to differentially adjust the sensitivity of vestibular neurons to transient and tonic stimulation and that such mechanisms may be targeted to achieve effective clinical management of vestibular disorders.<\/jats:p>","DOI":"10.1152\/jn.00384.2017","type":"journal-article","created":{"date-parts":[[2017,8,31]],"date-time":"2017-08-31T01:10:26Z","timestamp":1504141826000},"page":"2991-3006","source":"Crossref","is-referenced-by-count":32,"title":["Effect of M-current modulation on mammalian vestibular responses to transient head motion"],"prefix":"10.1152","volume":"118","author":[{"given":"Choongheon","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Special Education and Communication Disorders, University of Nebraska-Lincoln, Lincoln, Nebraska"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. 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