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Here single-unit data on cortical selectivity and response variability to FM sweeps of either direction and different rates (0.08\u201320 kHz\/ms) were compared across young (1\u20133 mo), middle-aged (6\u20138 mo), and old (14\u201320 mo) groups. Three main findings are reported. First, there is a reduction in FM rate selectivity in the old group. Second, there is a slowing of the sweep rates at which neurons likely provide best detection and discrimination of sweep rates. Third, there is an increase in trial-to-trial variability in the magnitude and timing of spikes in response to sweeps. These changes were only observed in neurons that were selective for the fast or intermediate range of sweep rates and not in neurons that preferred slow sweeps or were nonselective. Increased variability of response magnitude, but not changes in temporal fidelity or selectivity, was seen even in the middle-aged group. The results show that spectrotemporal processing becomes slow and noisy with presbycusis in specific types of neurons, suggesting receptive field mechanisms that are altered. These data suggest neural correlates of presbycusis-related reduction in the ability of humans to process rapid spectrotemporal changes.<\/jats:p>","DOI":"10.1152\/jn.00423.2013","type":"journal-article","created":{"date-parts":[[2013,9,26]],"date-time":"2013-09-26T04:26:45Z","timestamp":1380169605000},"page":"2873-2886","source":"Crossref","is-referenced-by-count":23,"title":["Altered cortical spectrotemporal processing with age-related hearing loss"],"prefix":"10.1152","volume":"110","author":[{"given":"Michael","family":"Trujillo","sequence":"first","affiliation":[{"name":"Graduate Neuroscience Program and Department of Psychology, University of California, Riverside, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khaleel A.","family":"Razak","sequence":"additional","affiliation":[{"name":"Graduate Neuroscience Program and Department of Psychology, University of California, Riverside, 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