{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T17:44:12Z","timestamp":1787507052250,"version":"build-2736575974"},"reference-count":101,"publisher":"American Physiological Society","issue":"6","funder":[{"DOI":"10.13039\/100004411","name":"Heart and Stroke Foundation of Canada","doi-asserted-by":"publisher","award":["G-19-0024266"],"award-info":[{"award-number":["G-19-0024266"]}],"id":[{"id":"10.13039\/100004411","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000038","name":"Canadian Government | Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","award":["RGPIN\/04624-2017"],"award-info":[{"award-number":["RGPIN\/04624-2017"]}],"id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Canadian Government I New Frontiers in Research","award":["NFRFE-2020-00978"],"award-info":[{"award-number":["NFRFE-2020-00978"]}]}],"content-domain":{"domain":["journals.physiology.org"],"crossmark-restriction":true},"short-container-title":["Journal of Neurophysiology"],"published-print":{"date-parts":[[2025,6,1]]},"abstract":"<jats:p>With stroke, traumatic brain injury, or sudden cardiac arrest, there is no therapeutic drug to aid brain recovery. Within 2 min of severe ischemia, a wave of spreading depolarization (SD) propagates through affected gray matter. More SDs arise over hours, expanding the injury. This period represents a therapeutic window to inhibit recurring SD and reduce neuronal damage, but we do not understand the underlying molecular sequence. Here, we argue for a novel molecule to target.<\/jats:p>","DOI":"10.1152\/jn.00429.2024","type":"journal-article","created":{"date-parts":[[2025,5,7]],"date-time":"2025-05-07T09:50:14Z","timestamp":1746611414000},"page":"1649-1664","update-policy":"https:\/\/doi.org\/10.1152\/aps-crossmark-policy","source":"Crossref","is-referenced-by-count":8,"title":["Simulated ischemia in live cerebral slices is mimicked by opening the Na\n                    <sup>+<\/sup>\n                    \/K\n                    <sup>+<\/sup>\n                    pump: clues to the generation of spreading depolarization"],"prefix":"10.1152","volume":"133","author":[{"given":"Danielle","family":"Kim","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02y72wh86","id-type":"ROR","asserted-by":"publisher"}],"name":"Queen\u2019s University","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Gagolewicz","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02y72wh86","id-type":"ROR","asserted-by":"publisher"}],"name":"Queen\u2019s University","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2456-6167","authenticated-orcid":false,"given":"Sydney","family":"McQueen","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02y72wh86","id-type":"ROR","asserted-by":"publisher"}],"name":"Queen\u2019s University","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannah","family":"Latour","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02y72wh86","id-type":"ROR","asserted-by":"publisher"}],"name":"Queen\u2019s University","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaitlyn","family":"Tresidder","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02y72wh86","id-type":"ROR","asserted-by":"publisher"}],"name":"Queen\u2019s University","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cathryn R.","family":"Jarvis","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02y72wh86","id-type":"ROR","asserted-by":"publisher"}],"name":"Queen\u2019s University","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4857-7314","authenticated-orcid":false,"given":"R. David","family":"Andrew","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02y72wh86","id-type":"ROR","asserted-by":"publisher"}],"name":"Queen\u2019s University","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21207609"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.111.632943"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awl392"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.2010.191"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2333"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0707530"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410360404"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/122.12.2387"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhaa134"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhk032"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1007\/s12028-021-01429-4"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.23-37-11602.2003"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1177\/0271678X16654495"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awh716"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1097\/00004647-200002000-00024"},{"key":"B16","first-page":"13","volume-title":"New Strategies in Stroke Intervention","author":"Di Renzo G","year":"2010"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1111\/j.1750-3639.1994.tb00808.x"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1177\/0271678X16653135"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1947.10.6.409"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1093\/oso\/9780195151718.001.0001"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1139\/y92-268"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1997.78.2.891"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/11.3.249"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneumeth.2007.07.012"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5128-07.2008"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-21425-2_10"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0096585"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1007\/s13760-012-0007-3"},{"key":"B29","first-page":"648","volume":"19","author":"Falini A","year":"1998","journal-title":"Am J Neuroradiol"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1989.00520370095028"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1002\/neu.480120303"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1016\/0022-510x(77)90014-4"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0079589"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00090.2012"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2020.07.009"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.2741\/1704"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1016\/j.semnephrol.2005.03.004"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00654.2004"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1007\/s10827-008-0103-9"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(93)91154-K"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.2008.0243"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1038\/nature05129"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxicon.2010.09.011"},{"key":"B44","first-page":"13","volume-title":"New Strategies in Stroke Intervention","author":"Gottron MA","year":"2010"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1016\/0166-2236(94)90008-6"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1016\/0165-0270(94)00199-Q"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0437775100"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1126\/science.172.3982.495"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1007\/s00232-002-1074-9"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0018235"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxicon.2010.09.012"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.3390\/md8072021"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1007\/BF00503920"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1007\/BF00497672"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1016\/S0026-895X(25)10563-4"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1016\/S0041-0101(96)00136-5"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1085\/jgp.200308964"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00701.2011"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.physiol.69.031905.164816"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.2008.0245"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1152\/physiol.00013.2004"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1177\/0271678X16657344"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(94)90372-7"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0022351"},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00321.2002"},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.1007\/s12028-021-01326-w"},{"key":"B67","volume-title":"Introduction to Visibility","author":"Malm WC","year":"1999"},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.1002\/glia.20747"},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00817.2010"},{"key":"B70","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)00084-2"},{"key":"B71","doi-asserted-by":"publisher","DOI":"10.1152\/jn.2001.85.1.414"},{"key":"B72","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1917-10.2010"},{"key":"B73","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2009.0961"},{"key":"B74","doi-asserted-by":"publisher","DOI":"10.1002\/ana.25147"},{"key":"B75","doi-asserted-by":"publisher","DOI":"10.1007\/s12028-021-01431-w"},{"key":"B76","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0602720103"},{"key":"B77","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2002.tb04711.x"},{"key":"B78","doi-asserted-by":"publisher","DOI":"10.1006\/meth.1999.0771"},{"key":"B79","doi-asserted-by":"publisher","DOI":"10.1002\/glia.22390"},{"key":"B80","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awt026"},{"key":"B81","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2202-12-16"},{"key":"B82","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-1033.1985.tb09221.x"},{"key":"B83","doi-asserted-by":"publisher","DOI":"10.1085\/jgp.200709770"},{"key":"B84","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxicon.2009.02.030"},{"key":"B85","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxicon.2007.04.024"},{"key":"B86","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.107.498238"},{"key":"B87","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1999.81.4.1872"},{"key":"B90","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aaa4050"},{"key":"B91","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.2012.40"},{"key":"B92","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M112.425785"},{"key":"B93","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.1998.275.5.F633"},{"key":"B94","doi-asserted-by":"publisher","DOI":"10.1085\/jgp.110.2.201"},{"key":"B95","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)89442-5"},{"key":"B96","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-75975-w"},{"key":"B97","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00670.2018"},{"key":"B98","doi-asserted-by":"publisher","DOI":"10.1007\/BF00171047"},{"key":"B99","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-5793(97)00559-0"},{"key":"B100","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpj.2012.11.3832"},{"key":"B101","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00251.2024"},{"key":"B102","doi-asserted-by":"publisher","DOI":"10.3390\/md20080016"},{"key":"B103","doi-asserted-by":"publisher","unstructured":"Kim D, Gagolewicz P, McQueen S, Latour H, Tresidder K, Jarvis CR, Andrew RD. Simulated ischemia in live cerebral slices is mimicked by opening the Na\n                      +\n                      \/K\n                      +\n                      pump: clues to the generation of spreading depolarization (Preprint). bioRxiv, 2024. doi:10.1101\/2024.09.19.613937.","DOI":"10.1101\/2024.09.19.613937"}],"container-title":["Journal of Neurophysiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.physiology.org\/doi\/pdf\/10.1152\/jn.00429.2024","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,22]],"date-time":"2025-05-22T11:38:20Z","timestamp":1747913900000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.physiology.org\/doi\/10.1152\/jn.00429.2024"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,1]]},"references-count":101,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,6,1]]}},"alternative-id":["10.1152\/jn.00429.2024"],"URL":"https:\/\/doi.org\/10.1152\/jn.00429.2024","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2024.09.19.613937","asserted-by":"object"}]},"ISSN":["0022-3077","1522-1598"],"issn-type":[{"value":"0022-3077","type":"print"},{"value":"1522-1598","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6,1]]},"assertion":[{"value":"2024-09-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-10-30","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-04-04","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-05-22","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}