{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T10:55:02Z","timestamp":1788432902388,"version":"build-2803163510"},"reference-count":54,"publisher":"American Physiological Society","issue":"6","funder":[{"DOI":"10.13039\/501100002367","name":"The national basic research program grants","doi-asserted-by":"publisher","award":["2015CB553501"],"award-info":[{"award-number":["2015CB553501"]}],"id":[{"id":"10.13039\/501100002367","id-type":"DOI","asserted-by":"publisher"}]},{"name":"The National natural science foundation grants","award":["31871111"],"award-info":[{"award-number":["31871111"]}]},{"name":"The national natural science foundation grants","award":["91332115"],"award-info":[{"award-number":["91332115"]}]},{"DOI":"10.13039\/501100015750","name":"Key laboratory of mental health, Institute of Psychology, CAS","doi-asserted-by":"crossref","award":["KSCX2-EW-R-12"],"award-info":[{"award-number":["KSCX2-EW-R-12"]}],"id":[{"id":"10.13039\/501100015750","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100002367","name":"Chinese Academy of Sciences","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100002367","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["journals.physiology.org"],"crossmark-restriction":true},"short-container-title":["Journal of Neurophysiology"],"published-print":{"date-parts":[[2021,6,1]]},"abstract":"<jats:p> We investigated for the first time how the duration of withdrawal affects mAChRs functions in the nucleus accumbens in neonatal rats. Compared with short-term withdrawal time, rats showed downregulation of presynaptic and post\/extrasynaptic mAChRs functions during long-term withdrawal time. Our finding introduces a new possible correlation between the mAChRs dysfunction in the nucleus accumbens and the development of withdrawal in neonates. <\/jats:p>","DOI":"10.1152\/jn.00441.2020","type":"journal-article","created":{"date-parts":[[2021,5,12]],"date-time":"2021-05-12T13:03:21Z","timestamp":1620824601000},"page":"2228-2236","update-policy":"https:\/\/doi.org\/10.1152\/aps-crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["The duration of withdrawal affects the muscarinic signaling in the nucleus accumbens after chronic morphine exposure in neonatal rats"],"prefix":"10.1152","volume":"125","author":[{"given":"Xiao","family":"Jiang","sequence":"first","affiliation":[{"name":"CAS Key Laboratory of Mental Health, Institute of Psychology, Beijing, People\u2019s Republic of China"},{"name":"Department of Psychology, University of Chinese Academy of Sciences, Beijing, People\u2019s Republic of China"},{"name":"Department of Medical Psychology, School of Mental Health and Psychological Sciences, Anhui Medical University, Hefei, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7526-7234","authenticated-orcid":false,"given":"Jian-Jun","family":"Zhang","sequence":"additional","affiliation":[{"name":"CAS Key Laboratory of Mental Health, Institute of Psychology, Beijing, People\u2019s Republic of China"},{"name":"Department of Psychology, University of Chinese Academy of Sciences, Beijing, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sen","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, School of Medicine, Tsinghua University, Beijing, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yonghui","family":"Li","sequence":"additional","affiliation":[{"name":"CAS Key Laboratory of Mental Health, Institute of Psychology, Beijing, People\u2019s Republic of China"},{"name":"Department of Psychology, University of Chinese Academy of Sciences, Beijing, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nan","family":"Sui","sequence":"additional","affiliation":[{"name":"CAS Key Laboratory of Mental Health, Institute of Psychology, Beijing, People\u2019s Republic of China"},{"name":"Department of Psychology, University of Chinese Academy of Sciences, Beijing, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2014.08.005"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1007\/s002130000413"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1126\/science.1063024"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2013.04.061"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1038\/35094560"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1038\/nrn2234"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.neuro.29.051605.113009"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-017-4689-3"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1016\/0301-0082(94)90025-6"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1038\/sj.npp.1301585"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1016\/s0166-2236(99)01501-5"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1002\/neu.10150"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1007\/s002130050866"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(95)00319-g"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0631749100"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2008.09.009"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1016\/s0028-3908(00)00012-5"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1002\/1098-2396(200010)38:1<61::AID-SYN7>3.0.CO;2-6"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1007\/s002130100885"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1038\/sj.npp.1300854"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbb.2016.03.006"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.33549\/physiolres.932518"},{"key":"B24","first-page":"1067","volume":"244","author":"Di Chiara G","year":"1988","journal-title":"J Pharmacol Exp Ther"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1016\/j.molbrainres.2004.03.011"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-014-3756-2"},{"key":"B27","first-page":"279","volume":"50","author":"Caulfield MP","year":"1998","journal-title":"Pharmacol Rev"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1016\/j.conb.2011.04.004"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1177\/1073858402239588"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1046\/j.1460-9568.2002.02289.x"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(94)91656-x"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1152\/jn.01025.2001"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(95)00631-1"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(95)00588-7"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.162.8.1403"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2004.03576.x"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1990.sp017989"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1381-05.2005"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresrev.2007.02.004"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2010.07.039"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3227-05.2006"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2008.06.075"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5703-08.2009"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2011.06.001"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1046\/j.1360-0443.2001.9611038.x"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2012.07.046"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20030508"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2008.08.002"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1002\/syn.20067"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-012-2784-z"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2004.06.027"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1124\/pr.109.001933"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.23025"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2012.02.020"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-2396(199711)27:3<262::AID-SYN10>3.0.CO;2-W"}],"container-title":["Journal of Neurophysiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.physiology.org\/doi\/pdf\/10.1152\/jn.00441.2020","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,6,23]],"date-time":"2021-06-23T10:03:22Z","timestamp":1624442602000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.physiology.org\/doi\/10.1152\/jn.00441.2020"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6,1]]},"references-count":54,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2021,6,1]]}},"alternative-id":["10.1152\/jn.00441.2020"],"URL":"https:\/\/doi.org\/10.1152\/jn.00441.2020","relation":{},"ISSN":["0022-3077","1522-1598"],"issn-type":[{"value":"0022-3077","type":"print"},{"value":"1522-1598","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,6,1]]},"assertion":[{"value":"2020-07-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-05-04","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-06-02","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}