{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T01:54:38Z","timestamp":1791165278198,"version":"4.1.0"},"reference-count":49,"publisher":"American Physiological Society","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Neurophysiology"],"published-print":{"date-parts":[[2003,12]]},"abstract":"<jats:p> Whole cell patch-clamp recordings of calcium-activated chloride current [ I<jats:sub>Cl(Ca)<\/jats:sub>] were made from adult sensory neurons of naive and axotomized mouse L<jats:sub>4<\/jats:sub>\u2013L<jats:sub>6<\/jats:sub> lumbar dorsal root ganglia after 1 day of culture in vitro. A basal I<jats:sub>Cl(Ca)<\/jats:sub> was specifically expressed in a subset of naive medium-diameter neurons (30\u201340 \u03bcm). Prior nerve injury, induced by sciatic nerve transection 5 days before experiments, increased both I<jats:sub>Cl(Ca)<\/jats:sub> amplitude and its expression in medium-diameter neurons. Moreover, nerve injury also induced I<jats:sub>Cl(Ca)<\/jats:sub> expression in a new subpopulation of neurons, the large-diameter neurons (40\u201350 \u03bcm). Small-diameter neurons (inferior to 30 \u03bcm) never expressed I<jats:sub>Cl(Ca)<\/jats:sub>. Regulated I<jats:sub>Cl(Ca)<\/jats:sub> expression was strongly correlated with injury-induced regenerative growth of sensory neurons in vitro and nerve regeneration in vivo. Cell culture on a substrate not permissive for growth, d,l-polyornithine, prevented both elongation growth and I<jats:sub>Cl(Ca)<\/jats:sub> expression in axotomized neurons. Regenerative growth and the induction of I<jats:sub>Cl(Ca)<\/jats:sub> expression take place 2 days after injury, peak after 5 days of conditioning in vivo, slowly declining thereafter to control values. The selective expression of I<jats:sub>Cl(Ca)<\/jats:sub> within medium- and large-diameter neurons conditioned for rapid, efficient growth suggests that these channels play a specific role in postinjury behavior of sensory neuron subpopulations such as neuropathic pain and\/or axonal regeneration. <\/jats:p>","DOI":"10.1152\/jn.00449.2003","type":"journal-article","created":{"date-parts":[[2006,5,31]],"date-time":"2006-05-31T06:01:10Z","timestamp":1149055270000},"page":"3764-3773","source":"Crossref","is-referenced-by-count":82,"title":["Axotomy-Induced Expression of Calcium-Activated Chloride Current in Subpopulations of Mouse Dorsal Root Ganglion Neurons"],"prefix":"10.1152","volume":"90","author":[{"given":"Sylvain","family":"Andr\u00e9","sequence":"first","affiliation":[{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale U-583, Universit\u00e9 Montpellier II, 34095, Montpellier Cedex 5, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hassan","family":"Boukhaddaoui","sequence":"additional","affiliation":[{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale U-583, Universit\u00e9 Montpellier II, 34095, Montpellier Cedex 5, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brice","family":"Campo","sequence":"additional","affiliation":[{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale U-583, Universit\u00e9 Montpellier II, 34095, Montpellier Cedex 5, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed","family":"Al-Jumaily","sequence":"additional","affiliation":[{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale U-583, Universit\u00e9 Montpellier II, 34095, Montpellier Cedex 5, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V\u00e9ronique","family":"Mayeux","sequence":"additional","affiliation":[{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale U-583, Universit\u00e9 Montpellier II, 34095, Montpellier Cedex 5, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denis","family":"Greuet","sequence":"additional","affiliation":[{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale U-583, Universit\u00e9 Montpellier II, 34095, Montpellier Cedex 5, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean","family":"Valmier","sequence":"additional","affiliation":[{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale U-583, Universit\u00e9 Montpellier II, 34095, Montpellier Cedex 5, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fr\u00e9d\u00e9rique","family":"Scamps","sequence":"additional","affiliation":[{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale U-583, Universit\u00e9 Montpellier II, 34095, Montpellier Cedex 5, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"REF1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M205307200"},{"key":"REF2","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-1838(99)00058-2"},{"key":"REF3","doi-asserted-by":"publisher","DOI":"10.1152\/jn.2001.85.2.644"},{"key":"REF4","doi-asserted-by":"publisher","DOI":"10.1152\/jn.2001.85.2.630"},{"key":"REF5","doi-asserted-by":"publisher","DOI":"10.1097\/00001756-200301200-00027"},{"key":"REF6","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3940(99)00538-8"},{"key":"REF7","doi-asserted-by":"publisher","DOI":"10.1152\/jn.2000.83.4.2227"},{"key":"REF8","doi-asserted-by":"publisher","DOI":"10.1016\/0012-1606(89)90136-X"},{"key":"REF9","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.17-10-03503.1997"},{"key":"REF10","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1992.tb14381.x"},{"key":"REF11","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1997.sp021866"},{"key":"REF12","unstructured":"Devor M and Seltzer Z. 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