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Nitrendipine partially occluded this modulation at both stages, indicating that modulation of Ca<jats:sub>V<\/jats:sub>1 channels was present throughout this developmental interval. Nevertheless, modulation of Ca<jats:sub>V<\/jats:sub>1 channels was significantly larger in PD40 neurons. \u03c9-Conotoxin GVIA occluded most of the Ca<jats:sup>2+<\/jats:sup> current modulation in PD14 neurons. However, this occlusion was greatly decreased in PD40 neurons. \u03c9-Agatoxin TK occluded a great part of the modulation in PD40 neurons but had a negligible effect in PD14 neurons. The data indicate that dopaminergic D<jats:sub>2<\/jats:sub>-mediated modulation undergoes a change in target during development: from Ca<jats:sub>V<\/jats:sub>2.2 to Ca<jats:sub>V<\/jats:sub>2.1 Ca<jats:sup>2+<\/jats:sup> channels. This change occurred while Ca<jats:sub>V<\/jats:sub>2.2 channels were being down-regulated and Ca<jats:sub>V<\/jats:sub>2.1 channels were being up-regulated. Presynaptic modulation mediated by D<jats:sub>2<\/jats:sub> receptors reflected these changes; Ca<jats:sub>V<\/jats:sub>2.2 type channels were used for release in young animals but very little in mature animals, suggesting that changes took place simultaneously at the somatodendritic and the synaptic membranes. <\/jats:p>","DOI":"10.1152\/jn.00455.2005","type":"journal-article","created":{"date-parts":[[2005,8,25]],"date-time":"2005-08-25T00:24:55Z","timestamp":1124929495000},"page":"3771-3787","source":"Crossref","is-referenced-by-count":52,"title":["A Reconfiguration of Ca<sub>V<\/sub>2 Ca<sup>2+<\/sup> Channel Current and Its Dopaminergic D<sub>2<\/sub> Modulation in Developing Neostriatal Neurons"],"prefix":"10.1152","volume":"94","author":[{"given":"Humberto","family":"Salgado","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatuel","family":"Tecuapetla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamara","family":"Perez-Rosello","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Azucena","family":"Perez-Burgos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrique","family":"Perez-Garci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elvira","family":"Galarraga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose","family":"Bargas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"R1","doi-asserted-by":"publisher","DOI":"10.1038\/72929"},{"key":"R2","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(01)00575-9"},{"key":"R3","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4227-04.2005"},{"key":"R4","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(98)00211-5"},{"key":"R5","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.14-11-06667.1994"},{"key":"R6","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4979-03.2004"},{"key":"R7","doi-asserted-by":"publisher","DOI":"10.1016\/0165-3806(90)90244-S"},{"key":"R8","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-0082(99)00030-1"},{"key":"R9","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.23-15-06245.2003"},{"key":"R10","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(98)00457-6"},{"key":"R11","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-2236(99)01520-9"},{"key":"R12","doi-asserted-by":"publisher","DOI":"10.1159\/000017310"},{"key":"R13","doi-asserted-by":"publisher","DOI":"10.1016\/S0028-3908(01)00038-7"},{"key":"R14","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2003.054247"},{"key":"R15","doi-asserted-by":"publisher","DOI":"10.1002\/syn.10114"},{"key":"R16","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3940(97)00784-2"},{"key":"R17","doi-asserted-by":"publisher","DOI":"10.1152\/jn.2000.84.5.2225"},{"key":"R18","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-2396(199907)33:1<26::AID-SYN3>3.0.CO;2-4"},{"key":"R19","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.15-12-08167.1995"},{"key":"R20","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.23-26-08931.2003"},{"key":"R21","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.17-09-03334.1997"},{"key":"R22","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.20-24-08987.2000"},{"key":"R23","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00771.2004"},{"key":"R24","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.20-01-00059.2000"},{"key":"R25","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7793.1998.419bn.x"},{"key":"R26","doi-asserted-by":"publisher","DOI":"10.1002\/cne.903550308"},{"key":"R27","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1999.82.4.1793"},{"key":"R28","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2002.031773"},{"key":"R29","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3327-04.2005"},{"key":"R30","doi-asserted-by":"publisher","DOI":"10.1007\/BF00228552"},{"key":"R31","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1994.sp020379"},{"key":"R32","doi-asserted-by":"publisher","DOI":"10.1097\/00001756-200307010-00013"},{"key":"R33","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00853.2004"},{"key":"R34","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1992.68.1.287"},{"key":"R35","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-2236(03)00196-6"},{"key":"R36","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.18-01-00266.1998"},{"key":"R37","unstructured":"Prescott TJ, Gurney K, and Redgrave P. 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