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We hypothesized that regions involved in the integration of target and effector information should not only respond to each of the two instruction cues, but should respond more strongly to the second cue due to the added integrative processing to establish the reach plan. We found bilateral regions in the posterior parietal cortex, the premotor cortex, the medial frontal cortex, and the insular cortex to be involved in target\u2013arm integration, as well as the left dorsolateral prefrontal cortex and an area in the right lateral occipital sulcus to respond in this manner. We further determined the functional properties of these regions in terms of spatial and effector specificity. This showed that the posterior parietal cortex and the dorsal premotor cortex specify both the spatial location of a target and the effector selected for the response. We therefore conclude that these regions are selectively engaged in the neural computations for reach planning, consistent with the results from physiological studies in nonhuman primates. <\/jats:p>","DOI":"10.1152\/jn.00456.2006","type":"journal-article","created":{"date-parts":[[2006,8,23]],"date-time":"2006-08-23T20:45:00Z","timestamp":1156365900000},"page":"188-199","source":"Crossref","is-referenced-by-count":191,"title":["Integration of Target and Effector Information in the Human Brain During Reach Planning"],"prefix":"10.1152","volume":"97","author":[{"given":"S. M.","family":"Beurze","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F. P.","family":"de Lange","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Toni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W. 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