{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:47:54Z","timestamp":1787017674385,"version":"build-2736575974"},"reference-count":69,"publisher":"American Physiological Society","issue":"1","funder":[{"DOI":"10.13039\/100000738","name":"U.S. Department of Veterans Affairs","doi-asserted-by":"publisher","award":["BX003451"],"award-info":[{"award-number":["BX003451"]}],"id":[{"id":"10.13039\/100000738","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.physiology.org"],"crossmark-restriction":true},"short-container-title":["Journal of Neurophysiology"],"published-print":{"date-parts":[[2025,7,1]]},"abstract":"<jats:p>Many in the United States with pain self-medicate with delta-9 tetrahydrocannabinol (THC) and cannabis, and many humans use e-cigarette-type devices filled with cannabis extracts to self-administer THC. Until recently, most rodent studies have used injection procedures and male rats. Chronic THC vapor reduced synaptic inhibition and neural firing in ventrolateral periaqueductal gray (vlPAG) neurons in males and rescued chronic inflammatory pain-induced increase in synaptic inhibition in females.<\/jats:p>","DOI":"10.1152\/jn.00456.2024","type":"journal-article","created":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T09:30:32Z","timestamp":1747215032000},"page":"80-93","update-policy":"https:\/\/doi.org\/10.1152\/aps-crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Chronic inflammatory pain and chronic THC vapor inhalation alter midbrain neuronal activity"],"prefix":"10.1152","volume":"134","author":[{"given":"Leslie K.","family":"Kelley","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/01qv8fp92","id-type":"ROR","asserted-by":"publisher"}],"name":"Louisiana State University Health Sciences Center (LSUHSC)","place":["United States"]},{"id":[{"id":"https:\/\/ror.org\/01qv8fp92","id-type":"ROR","asserted-by":"publisher"}],"name":"Louisiana State University Health Sciences Center (LSUHSC)","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas W.","family":"Gilpin","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/01qv8fp92","id-type":"ROR","asserted-by":"publisher"}],"name":"Louisiana State University Health Sciences Center (LSUHSC)","place":["United States"]},{"id":[{"id":"https:\/\/ror.org\/01qv8fp92","id-type":"ROR","asserted-by":"publisher"}],"name":"Louisiana State University Health Sciences Center (LSUHSC)","place":["United States"]},{"name":"Louisiana State University Health Science Center","place":["United States"]},{"name":"Southeast Louisiana VA Healthcare System","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4309-5252","authenticated-orcid":false,"given":"Jason W.","family":"Middleton","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/01qv8fp92","id-type":"ROR","asserted-by":"publisher"}],"name":"Louisiana State University Health Sciences Center (LSUHSC)","place":["United States"]},{"name":"Louisiana State University Health Science Center","place":["United States"]},{"name":"Southeast Louisiana VA Healthcare System","place":["United States"]},{"name":"Louisiana State University Health Sciences Center","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2017.51"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1089\/can.2017.0012"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1093\/pm\/pnaa060"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2015-1727"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.17269\/cjph.107.5747"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1080\/10826084.2016.1268162"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpain.2016.03.002"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1377\/hlthaff.2016.1135"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1038\/s41386-018-0011-2"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1016\/s0301-0082(02)00009-6"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2007.07.012"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1928-15.2016"},{"key":"B13","doi-asserted-by":"publisher","unstructured":"McPherson KB, Bouchet CA, Ingram SL. Physiologically distinct neurons within the ventrolateral periaqueductal gray are not defined by mu-opioid receptor expression but are differentially activated by persistent inflammation (Preprint). bioRxiv, 2021. doi:10.1101\/2021.06.16.448597.","DOI":"10.1101\/2021.06.16.448597"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.ne.07.030184.001521"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1097\/00001756-199910190-00001"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2007.03.053"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2016.12"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.2174\/187152709789824660"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2017.06.015"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2015.00006"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2012.03.038"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3565(25)12310-0"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1038\/26481"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph120809988"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2015.12.020"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpain.2022.09.002"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1016\/j.euroneuro.2017.10.037"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbb.2018.07.007"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-021-05995-5"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbb.2021.173116"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2021.108827"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1093\/jat\/bkac042"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-03242-7"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.964749"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2017.140"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpain.2024.104649"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.3389\/fncir.2010.00100"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3644-10.2010"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0836-14.2015"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyg.2013.00863"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1038\/nn.2441"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1038\/nn.2630"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1085\/jgp.202012826"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvx151"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.18-10-03870.1998"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2020.107495"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.1999.0732447.x"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0901507106"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2013.01.030"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3536-06.2007"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.68760"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2019.09.011"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1523\/ENEURO.0129-16.2017"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2008.09.009"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1009532107"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2023.1159753"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1177\/17448069241270295"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(92)90400-v"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1159\/000496974"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2021.03.001"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1523\/ENEURO.0018-18.2019"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3686-06.2007"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1999.82.4.1843"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00211.2004"},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00514.2012"},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.1038\/nature09559"},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.1038\/nature09553"},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.1523\/ENEURO.0402-20.2020"},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.1113\/JP276935"}],"container-title":["Journal of Neurophysiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.physiology.org\/doi\/pdf\/10.1152\/jn.00456.2024","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,25]],"date-time":"2025-06-25T08:09:08Z","timestamp":1750838948000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.physiology.org\/doi\/10.1152\/jn.00456.2024"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,1]]},"references-count":69,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,7,1]]}},"alternative-id":["10.1152\/jn.00456.2024"],"URL":"https:\/\/doi.org\/10.1152\/jn.00456.2024","relation":{},"ISSN":["0022-3077","1522-1598"],"issn-type":[{"value":"0022-3077","type":"print"},{"value":"1522-1598","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,1]]},"assertion":[{"value":"2024-10-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-11-06","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-05-06","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-06-25","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}