{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T15:34:01Z","timestamp":1788449641444,"version":"build-2803163510"},"reference-count":51,"publisher":"American Physiological Society","issue":"3","funder":[{"DOI":"10.13039\/100000057","name":"HHS | NIH | National Institute of General Medical Sciences (NIGMS)","doi-asserted-by":"publisher","award":["U54-GM104941"],"award-info":[{"award-number":["U54-GM104941"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"HHS | NIH | National Institute of General Medical Sciences (NIGMS)","doi-asserted-by":"publisher","award":["P20 GM113125"],"award-info":[{"award-number":["P20 GM113125"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Neurophysiology"],"published-print":{"date-parts":[[2019,3,1]]},"abstract":"<jats:p> A positive family history of hypertension (+FH) is a risk factor for the future development of hypertension. Hypertension is associated with reductions in baroreflex sensitivity (BRS). Therefore, we hypothesized that young women with a +FH [ n = 12, 22\u2009\u00b1\u20091 yr, body mass index (BMI) 21\u2009\u00b1\u20091 kg\/m<jats:sup>2<\/jats:sup>, mean arterial pressure (MAP) 79\u2009\u00b1\u20091 mmHg] would have lower BRS compared with young women without a family history of hypertension (\u2212FH) ( n = 13, 22\u2009\u00b1\u20091 yr, BMI 21\u2009\u00b1\u20091 kg\/m<jats:sup>2<\/jats:sup>, MAP 77\u2009\u00b1\u20092 mmHg, all P &gt; 0.05 between groups). Continuous measurements of muscle sympathetic nerve activity, blood pressure, and electrocardiogram derived R-R interval were recorded at rest and during a Valsalva maneuver. Both cardiovagal BRS and vascular sympathetic BRS were assessed. Resting cardiovagal BRS was reduced in the +FH women (all sequences: \u2212FH 32.3\u2009\u00b1\u20093.7 vs. +FH 20.2\u2009\u00b1\u20092.9 ms\/mmHg, P = 0.02). Cardiovagal BRS during phase IV (\u2212FH 16.5\u2009\u00b1\u20092.7 vs. +FH 7.6\u2009\u00b1\u20091.3 ms\/mmHg, P &lt; 0.01) but not phase II (\u2212FH 5.5\u2009\u00b1\u20090.9 vs. +FH 5.0\u2009\u00b1\u20090.8 ms\/mmHg, P = 0.67) of the Valsalva maneuver was also lower in the +FH women. Vascular sympathetic BRS at rest (\u2212FH \u22122.38\u2009\u00b1\u20090.7 vs. +FH \u22122.33\u2009\u00b1\u20090.3 bursts\u00b7 min<jats:sup>\u22121<\/jats:sup>\u00b7mmHg<jats:sup>\u22121<\/jats:sup>, P = 0.58) and during the Valsalva (\u2212FH \u22120.74\u2009\u00b1\u20090.23 vs. +FH \u22120.66\u2009\u00b1\u20090.18 bursts\u00b715 s<jats:sup>\u22121<\/jats:sup>\u00b7mmHg<jats:sup>\u22121<\/jats:sup>, P = 0.79) were not different between groups. These data suggest that healthy young women with a positive family history of hypertension have reduced cardiovagal BRS. This may be one mechanism contributing to the increased incidence of hypertension in this population later in life. <\/jats:p><jats:p> NEW &amp; NOTEWORTHY Having a family history of hypertension increases the risk of developing future hypertension. Reductions in baroreflex function have been demonstrated in hypertension and are an important marker for future cardiovascular disease. We show that young women with a family history of hypertension have lower cardiovagal baroreflex sensitivity. This alteration in autonomic function may be one mechanism contributing to the future incidence of hypertension in this patient population. <\/jats:p>","DOI":"10.1152\/jn.00471.2018","type":"journal-article","created":{"date-parts":[[2019,1,23]],"date-time":"2019-01-23T15:17:56Z","timestamp":1548256676000},"page":"1011-1017","source":"Crossref","is-referenced-by-count":19,"title":["Altered baroreflex sensitivity in young women with a family history of hypertension"],"prefix":"10.1152","volume":"121","author":[{"given":"Evan L.","family":"Matthews","sequence":"first","affiliation":[{"name":"Department of Kinesiology and Applied Physiology, University of Delaware, Newark, Delaware"},{"name":"Exercise Science and Physical Education Department, Montclair State University, Montclair, New Jersey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelly N.","family":"Sebzda","sequence":"additional","affiliation":[{"name":"Department of Kinesiology and Applied Physiology, 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