{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T02:35:18Z","timestamp":1780454118898,"version":"3.54.1"},"reference-count":40,"publisher":"American Physiological Society","issue":"4","funder":[{"DOI":"10.13039\/100000065","name":"HHS | NIH | National Institute of Neurological Disorders and Stroke (NINDS)","doi-asserted-by":"publisher","award":["NS072197"],"award-info":[{"award-number":["NS072197"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006545","name":"HHS | NIH | National Institute on Minority Health and Health Disparities (NIMHD)","doi-asserted-by":"publisher","award":["G12MD007591"],"award-info":[{"award-number":["G12MD007591"]}],"id":[{"id":"10.13039\/100006545","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Neurophysiology"],"published-print":{"date-parts":[[2016,10,1]]},"abstract":"<jats:p> Striatal low-threshold spiking (LTS) interneurons spontaneously transition to a depolarized, oscillating state similar to that seen after sodium channels are blocked. In the depolarized state, whether spontaneous or induced by sodium channel blockade, the neurons express a 3- to 7-Hz oscillation and membrane impedance resonance in the same frequency range. The membrane potential oscillation and membrane resonance are expressed in the same voltage range (greater than \u221240 mV). We identified and recorded from LTS interneurons in striatal slices from a mouse that expressed green fluorescent protein under the control of the neuropeptide Y promoter. The membrane potential oscillation depended on voltage-gated calcium channels. Antagonism of L-type calcium currents (Ca<jats:sub>V<\/jats:sub>1) reduced the amplitude of the oscillation, whereas blockade of N-type calcium currents (Ca<jats:sub>V<\/jats:sub>2.2) reduced the frequency. Both calcium sources activate a calcium-activated chloride current (CaCC), the blockade of which abolished the oscillation. The blocking of any of these three channels abolished the membrane resonance. Immunohistochemical staining indicated anoctamin 2 (ANO2), and not ANO1, as the CaCC source. Biophysical modeling showed that Ca<jats:sub>V<\/jats:sub>1, Ca<jats:sub>V<\/jats:sub>2.2, and ANO2 are sufficient to generate a membrane potential oscillation and membrane resonance, similar to that in LTS interneurons. LTS interneurons exhibit a membrane potential oscillation and membrane resonance that are both generated by Ca<jats:sub>V<\/jats:sub>1 and Ca<jats:sub>V<\/jats:sub>2.2 activating ANO2. They can spontaneously enter a state in which the membrane potential oscillation dominates the physiological properties of the neuron. <\/jats:p>","DOI":"10.1152\/jn.00511.2016","type":"journal-article","created":{"date-parts":[[2016,7,20]],"date-time":"2016-07-20T21:39:37Z","timestamp":1469050777000},"page":"1752-1764","source":"Crossref","is-referenced-by-count":37,"title":["The ionic mechanism of membrane potential oscillations and membrane resonance in striatal LTS interneurons"],"prefix":"10.1152","volume":"116","author":[{"given":"S. C.","family":"Song","sequence":"first","affiliation":[{"name":"Department of Biology, The University of Texas at San Antonio, San Antonio, Texas; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. 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