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During postural tremor, spectral cross-correlation analysis demonstrated that 51% of the neurons studied exhibited a concentration of power at tremor frequency that was correlated with electromyography, i.e., tremor neurons. During rest, thalamic neurons did not exhibit tremor-frequency activity. Among the three thalamic nuclei surveyed, Vim had a significantly higher proportion of tremor neurons than did the principal somatic sensory nucleus ( ventral caudal, Vc) or a pallidal recipient thalamic nucleus ( ventral oral posterior, Vop). Neurons related to active movement (voluntary neurons) had significantly greater tremor-related activity than did nonvoluntary neurons. These findings are not consistent with a model of continuous olivo-cerebellar driving of the motor cortex through thalamic connections. Instead ET may be facilitated by motor circuits that enable tremor-related thalamic activity during voluntary movement. Additionally, a subgroup of tremor neurons with proprioceptive inputs were identified that may allow sensory feedback to access the central tremor network.<\/jats:p>","DOI":"10.1152\/jn.00527.2004","type":"journal-article","created":{"date-parts":[[2004,8,19]],"date-time":"2004-08-19T00:14:32Z","timestamp":1092874472000},"page":"117-127","source":"Crossref","is-referenced-by-count":122,"title":["Posture-Related Oscillations in Human Cerebellar Thalamus in Essential Tremor Are Enabled by Voluntary Motor Circuits"],"prefix":"10.1152","volume":"93","author":[{"given":"Sherwin E.","family":"Hua","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederick A.","family":"Lenz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"R1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.1974.54.4.957"},{"key":"R2","unstructured":"Bendat JSand Piersol AG.Random Data.New York: Wiley, 1976."},{"key":"R3","doi-asserted-by":"publisher","DOI":"10.1109\/TAU.1969.1162046"},{"key":"R4","doi-asserted-by":"publisher","DOI":"10.1002\/mds.870131311"},{"key":"R5","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410390515"},{"key":"R6","doi-asserted-by":"crossref","unstructured":"Brin MFand Koller W.Epidemiology and genetics of essential tremor.Mov Disord13,Suppl3: 55\u201363, 1998.","DOI":"10.1002\/mds.870131310"},{"key":"R7","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410410108"},{"key":"R8","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1996.75.3.1105"},{"key":"R9","doi-asserted-by":"publisher","DOI":"10.1007\/s002210050293"},{"key":"R10","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1984.sp015155"},{"key":"R11","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(90)92489-5"},{"key":"R12","unstructured":"Desmedt JE.Cerebral Motor Control in Man: Long Loop Mechanisms.Basel: Karger, 1978."},{"key":"R13","doi-asserted-by":"publisher","DOI":"10.1002\/mds.870131303"},{"key":"R14","doi-asserted-by":"publisher","DOI":"10.1002\/mds.10141"},{"key":"R15","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.50.11.1435"},{"key":"R16","doi-asserted-by":"publisher","DOI":"10.1002\/mds.870040210"},{"key":"R17","doi-asserted-by":"publisher","DOI":"10.1097\/00004691-199603000-00004"},{"key":"R18","doi-asserted-by":"crossref","unstructured":"Elble RJ.Animal models of action tremor.Mov Disord13 Suppl 3: 35\u201339, 1998.","DOI":"10.1002\/mds.870131306"},{"key":"R19","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4886(92)90014-H"},{"key":"R20","unstructured":"Elble RJand Koller W.Tremor.Baltimore, MD: Johns Hopkins University Press, 1990."},{"key":"R21","unstructured":"Fahn S, Tolosa E, and Marin C.Clinical rating scale for tremor. 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