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While the patients were standing upright with 30\u00b0 knee flexion, a force of 300 N was applied to the knee to induce posterior\u2013anterior tibial translation. Activity of m. semitendinosus\/semimembranosus was measured using surface electromyography (EMG). A linear potentiometer was placed on the tibial tuberosity and measured maximum tibial translation during standing (i.e., functional condition). In addition, knee laxity was assessed with a KT1000 arthrometer under passive conditions. After ACL rupture, the short-latency response (SLR) latency remained unchanged ( P = 0.21), whereas for the medium-latency response (MLR) it was significantly longer ( P &lt; 0.001). Significantly longer MLR latencies were noted for noncopers compared with copers ( P &lt; 0.01), whereas SLR latencies were similar. Significant differences between healthy and injured legs were noted after tibial translations using KT1000 ( P &lt; 0.001) and during stance ( P &lt; 0.001). Mechanical knee instability was found to be unchanged between copers and noncopers (KT1000: P = 0.97; tibial translation: P = 0.31). These results indicate that ACL rupture is associated with altered stretch reflex excitability, which may lead to \u201cgiving way\u201d symptoms, and that altered stretch reflex excitability may be more important for the development of \u201cgiving way\u201d than the mechanical instability of the knee. <\/jats:p>","DOI":"10.1152\/jn.00529.2006","type":"journal-article","created":{"date-parts":[[2006,8,30]],"date-time":"2006-08-30T20:47:43Z","timestamp":1156970863000},"page":"474-480","source":"Crossref","is-referenced-by-count":37,"title":["Changes in Stretch Reflex Excitability Are Related to \u201cGiving Way\u201d Symptoms in Patients With Anterior Cruciate Ligament Rupture"],"prefix":"10.1152","volume":"97","author":[{"given":"M.","family":"Melnyk","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Faist","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Gothner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Claes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Friemert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"R1","doi-asserted-by":"publisher","DOI":"10.1097\/00003086-200003000-00022"},{"key":"R2","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-199302000-00021"},{"key":"R3","doi-asserted-by":"publisher","DOI":"10.1002\/jor.1100120211"},{"key":"R4","doi-asserted-by":"crossref","unstructured":"Beard DJ, Murray D, Price A, Alfaro-Adrian J, Gill H, and Dodd CA. 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