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DBS with an average rate of 130 Hz was more effective at reducing tremor when pulses were evenly spaced than when there were large differences between intrapair and interpair pulse intervals. Similar correlations were observed in the firing patterns of model neurons: increasing the difference between the intrapair and interpair intervals rendered model neurons more likely to fire synchronous bursts, more likely to fire irregularly, and less likely to entrain to the stimulus. The tremor responses provide evidence that the pulse-to-pulse frequency of DBS, not just its average rate, plays an important role in DBS function. Modeling results also suggest that effective DBS overrides oscillatory pathological activity and replaces it with more regularized neuronal firing patterns. <\/jats:p>","DOI":"10.1152\/jn.00547.2007","type":"journal-article","created":{"date-parts":[[2007,7,18]],"date-time":"2007-07-18T20:55:20Z","timestamp":1184792120000},"page":"1675-1684","source":"Crossref","is-referenced-by-count":43,"title":["Pulse-to-Pulse Changes in the Frequency of Deep Brain Stimulation Affect Tremor and Modeled Neuronal Activity"],"prefix":"10.1152","volume":"98","author":[{"given":"Merrill J.","family":"Birdno","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott E.","family":"Cooper","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali R.","family":"Rezai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Warren M.","family":"Grill","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"R1","doi-asserted-by":"publisher","DOI":"10.1007\/s10827-005-6560-5"},{"key":"R2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1691-04.2004"},{"key":"R3","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(91)91175-T"},{"key":"R4","doi-asserted-by":"publisher","DOI":"10.1016\/S0278-2626(03)00107-6"},{"key":"R5","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3940(96)12943-8"},{"key":"R6","doi-asserted-by":"publisher","DOI":"10.1007\/s00441-004-0936-0"},{"key":"R7","doi-asserted-by":"publisher","DOI":"10.3171\/jns.2004.101.1.0043"},{"key":"R8","doi-asserted-by":"publisher","DOI":"10.1177\/1359786806064327"},{"key":"R9","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.18-10-03574.1998"},{"key":"R10","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2005.02.050"},{"key":"R11","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2005.02.005"},{"key":"R12","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4757-6376-8_17"},{"key":"R13","doi-asserted-by":"publisher","DOI":"10.1017\/S1472928801000255"},{"key":"R14","doi-asserted-by":"publisher","DOI":"10.1097\/00001756-200405190-00011"},{"key":"R15","doi-asserted-by":"publisher","DOI":"10.1586\/14737175.4.3.465"},{"key":"R16","doi-asserted-by":"publisher","DOI":"10.1080\/01616412.2000.11740667"},{"key":"R17","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.23-05-01916.2003"},{"key":"R18","doi-asserted-by":"publisher","DOI":"10.1162\/neco.1997.9.6.1179"},{"key":"R19","doi-asserted-by":"publisher","DOI":"10.1046\/j.1528-1157.2002.26001.x"},{"key":"R20","doi-asserted-by":"crossref","unstructured":"Holsheimer J, Demeulemeester H, Nuttin B, de Sutter P. 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