{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T20:04:46Z","timestamp":1790798686429,"version":"4.1.0"},"reference-count":143,"publisher":"American Physiological Society","issue":"3","funder":[{"name":"NIH","award":["R21NS098129"],"award-info":[{"award-number":["R21NS098129"]}]},{"name":"NIH","award":["R01NS104219"],"award-info":[{"award-number":["R01NS104219"]}]},{"name":"NIH","award":["R21NS111248"],"award-info":[{"award-number":["R21NS111248"]}]},{"name":"NIH","award":["R21NS107761"],"award-info":[{"award-number":["R21NS107761"]}]},{"DOI":"10.13039\/100005191","name":"Craig H. Nielsen Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100005191","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100010843","name":"Foundation for Physical Medicine and Rehabilitation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100010843","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100005202","name":"Muscular Dystrophy Association (MDA)","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005202","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Les Turner Foundation"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Neurophysiology"],"published-print":{"date-parts":[[2019,9,1]]},"abstract":"<jats:p> Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by the loss of upper and lower motor neurons, which manifests clinically as progressive weakness. Although several epidemiological studies have found an association between traumatic brain injury (TBI) and ALS, there is not a consensus on whether TBI is an ALS risk factor. It may be that it can cause ALS in a subset of susceptible patients, based on a history of repetitive mild TBI and genetic predisposition. This cannot be determined based on clinical observational studies alone. Better preclinical models are necessary to evaluate the effects of TBI on ALS onset and progression. To date, only a small number of preclinical studies have been performed, mainly in the superoxide dismutase 1 transgenic rodents, which, taken together, have mixed results and notable methodological limitations. The more recent incorporation of additional animal models such as Drosophila flies, as well as patient-induced pluripotent stem cell-derived neurons, should facilitate a better understanding of a potential functional interaction between TBI and ALS. <\/jats:p>","DOI":"10.1152\/jn.00572.2018","type":"journal-article","created":{"date-parts":[[2019,5,22]],"date-time":"2019-05-22T13:55:44Z","timestamp":1558533344000},"page":"1174-1185","source":"Crossref","is-referenced-by-count":26,"title":["Impact of traumatic brain injury on amyotrophic lateral sclerosis: from bedside to bench"],"prefix":"10.1152","volume":"122","author":[{"given":"Colin K.","family":"Franz","sequence":"first","affiliation":[{"name":"Biologics Laboratory, Shirley Ryan AbilityLab, Chicago, Illinois"},{"name":"Department of Physical Medicine and Rehabilitation, Northwestern University Feinberg School of Medicine, Chicago, Illinois"},{"name":"The Ken &amp; Ruth Davee Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Divya","family":"Joshi","sequence":"additional","affiliation":[{"name":"Biologics Laboratory, Shirley Ryan AbilityLab, Chicago, Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth L.","family":"Daley","sequence":"additional","affiliation":[{"name":"The Ken &amp; Ruth Davee Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rogan A.","family":"Grant","sequence":"additional","affiliation":[{"name":"The Ken &amp; Ruth Davee Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyriakos","family":"Dalamagkas","sequence":"additional","affiliation":[{"name":"Department of Physical Medicine and Rehabilitation, McGovern Medical School, TIRR Memorial Hermann, Houston, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Audrey","family":"Leung","sequence":"additional","affiliation":[{"name":"Biologics Laboratory, Shirley Ryan AbilityLab, Chicago, Illinois"},{"name":"Department of Physical Medicine and Rehabilitation, Northwestern University Feinberg School of Medicine, Chicago, Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John D.","family":"Finan","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, NorthShore University HealthSystem, Evanston, Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evangelos","family":"Kiskinis","sequence":"additional","affiliation":[{"name":"The Ken &amp; Ruth Davee Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, Illinois"},{"name":"Department of Physiology, Northwestern University Feinberg School of Medicine, Chicago, Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2017.08.002"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0053376"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpj.2014.01.024"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.2000.0741951.x"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-014-1254-6"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/8.2.157"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1159\/000330167"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddy047"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2008.04.038"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1016\/j.conb.2019.03.001"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.3109\/17482968.2012.660954"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1038\/srep30550"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2009.11.018"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1038\/srep25252"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1038\/nchembio.1563"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1202922109"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000203120.85850.54"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2014.02.004"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwm153"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1038\/s41593-017-0047-3"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaa3650"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurol.2017.03.030"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2007.04.070"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1002\/mus.21180"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1242\/dmm.037424"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1038\/nchembio711"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2011.09.011"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1002\/ana.22051"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms6999"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1016\/j.pmr.2016.12.001"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2013.10.015"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3004052"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.4271\/2007-22-0005"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1089\/neu.1995.12.325"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2015.04.041"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000001522"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0007357"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1038\/nature14974"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.20-07-02534.2000"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2015.4262"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.61.6.750"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-1136(199807)23:3<249:AID-GLIA7>3.0.CO;2-#"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2017.71"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.4271\/2007-22-0002"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.3109\/21678421.2016.1154575"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M113.472746"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1038\/nn.4345"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)87453-X"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1159\/000136648"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.032539299"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.18648"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1089\/scd.2014.0531"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.15252\/embj.201591267"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaf6803"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/aws322"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1111\/j.1750-3639.2011.00513.x"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-011-0909-9"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1038\/nn.4085"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.3791\/52905"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1316895110"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0404.2008.01112.x"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M112.346072"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)61156-7"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2008.04.025"},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.1016\/j.stemcr.2018.04.020"},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2014.03.004"},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2016.04.007"},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.1126\/science.1247125"},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbiomech.2004.05.032"},{"key":"B70","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.neuro.31.060407.125547"},{"key":"B71","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2013.07.033"},{"key":"B72","doi-asserted-by":"publisher","DOI":"10.1038\/srep24547"},{"key":"B73","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.3749"},{"key":"B74","doi-asserted-by":"publisher","DOI":"10.1002\/ana.21147"},{"key":"B75","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2017.07.025"},{"key":"B76","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1789.2009.01029.x"},{"key":"B77","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2010.1596"},{"key":"B78","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.20708"},{"key":"B79","doi-asserted-by":"publisher","DOI":"10.1097\/NEN.0b013e3181a9d503"},{"key":"B80","doi-asserted-by":"publisher","DOI":"10.1097\/NEN.0b013e3181ee7d85"},{"key":"B81","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/aws307"},{"key":"B82","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2015.06.013"},{"key":"B83","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2013.11.006"},{"key":"B84","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddr284"},{"key":"B85","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2008.10.021"},{"key":"B86","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneumeth.2005.06.014"},{"key":"B87","doi-asserted-by":"publisher","DOI":"10.4271\/2003-22-0006"},{"key":"B88","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-bioeng-071910-124706"},{"key":"B89","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410380318"},{"key":"B90","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000134608.83927.B1"},{"key":"B91","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awl165"},{"key":"B92","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-004-0821-7"},{"key":"B93","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awn109"},{"key":"B94","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.1993.tb07437.x"},{"key":"B95","doi-asserted-by":"publisher","DOI":"10.1136\/bjsports-2015-094978"},{"key":"B96","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-7091-9465-2_15"},{"key":"B97","doi-asserted-by":"publisher","DOI":"10.1007\/s40279-017-0854-4"},{"key":"B99","doi-asserted-by":"publisher","DOI":"10.1038\/nn1653"},{"key":"B100","doi-asserted-by":"publisher","DOI":"10.1080\/21678421.2017.1386687"},{"key":"B101","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2014.01.011"},{"key":"B102","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.22510"},{"key":"B103","doi-asserted-by":"publisher","DOI":"10.1038\/nn.3584"},{"key":"B104","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2011.09.010"},{"key":"B105","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-013-7185-7"},{"key":"B106","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410380114"},{"key":"B107","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3007529"},{"key":"B108","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.59.5.773"},{"key":"B109","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2010.01.011"},{"key":"B110","doi-asserted-by":"publisher","DOI":"10.1016\/j.brs.2016.11.011"},{"key":"B111","doi-asserted-by":"publisher","DOI":"10.1016\/j.apmr.2009.11.011"},{"key":"B112","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1300398110"},{"key":"B113","doi-asserted-by":"publisher","DOI":"10.1038\/srep34097"},{"key":"B114","doi-asserted-by":"publisher","DOI":"10.1097\/00005072-199604000-00011"},{"key":"B115","doi-asserted-by":"publisher","DOI":"10.1007\/s100480050031"},{"key":"B116","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2014.09.027"},{"key":"B117","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.19-11-04263.1999"},{"key":"B118","doi-asserted-by":"publisher","DOI":"10.1126\/science.1154584"},{"key":"B119","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000218161.15834.db"},{"key":"B120","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2006.07.024"},{"key":"B121","doi-asserted-by":"publisher","DOI":"10.1038\/nature20413"},{"key":"B122","doi-asserted-by":"publisher","DOI":"10.1097\/TA.0000000000001248"},{"key":"B123","doi-asserted-by":"publisher","DOI":"10.1523\/ENEURO.0059-14.2015"},{"key":"B124","doi-asserted-by":"publisher","DOI":"10.1016\/j.pneurobio.2008.01.001"},{"key":"B125","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2009.10.010"},{"key":"B126","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0705046104"},{"key":"B127","doi-asserted-by":"publisher","DOI":"10.1242\/dmm.029058"},{"key":"B128","doi-asserted-by":"publisher","DOI":"10.1038\/nrm2970"},{"key":"B129","doi-asserted-by":"publisher","DOI":"10.1038\/s41593-018-0075-7"},{"key":"B130","doi-asserted-by":"publisher","DOI":"10.1089\/089771504322778596"},{"key":"B131","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2014.03.019"},{"key":"B132","doi-asserted-by":"publisher","DOI":"10.1007\/s11064-012-0791-4"},{"key":"B133","doi-asserted-by":"publisher","DOI":"10.1177\/1073858411435706"},{"key":"B134","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1911.02560250012006"},{"key":"B135","doi-asserted-by":"publisher","DOI":"10.1038\/nature11280"},{"key":"B136","doi-asserted-by":"publisher","DOI":"10.1179\/1743132812Y.0000000019"},{"key":"B137","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000099372.75786.F8"},{"key":"B138","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2013.04.003"},{"key":"B139","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.2014.105"},{"key":"B140","doi-asserted-by":"publisher","DOI":"10.1038\/nature10323"},{"key":"B141","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.2008.44"},{"key":"B142","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2013.9"},{"key":"B143","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2018.03.025"},{"key":"B144","doi-asserted-by":"publisher","DOI":"10.1038\/nature14973"}],"container-title":["Journal of Neurophysiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.physiology.org\/doi\/pdf\/10.1152\/jn.00572.2018","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,19]],"date-time":"2019-09-19T19:44:09Z","timestamp":1568922249000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.physiology.org\/doi\/10.1152\/jn.00572.2018"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9,1]]},"references-count":143,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2019,9,1]]}},"alternative-id":["10.1152\/jn.00572.2018"],"URL":"https:\/\/doi.org\/10.1152\/jn.00572.2018","relation":{},"ISSN":["0022-3077","1522-1598"],"issn-type":[{"value":"0022-3077","type":"print"},{"value":"1522-1598","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,9,1]]}}}