{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T15:37:32Z","timestamp":1790696252097,"version":"4.1.0"},"reference-count":82,"publisher":"American Physiological Society","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Neurophysiology"],"published-print":{"date-parts":[[2012,1]]},"abstract":"<jats:p>In this study, we examined the contribution of a low-threshold calcium current [I<jats:sub>Ca(T)<\/jats:sub>] to locomotor-related activity in the neonatal mouse. Specifically, the role of I<jats:sub>Ca(T)<\/jats:sub>was studied during chemically induced, locomotor-like activity in the isolated whole cord and in a genetically distinct population of ventromedial spinal interneurons marked by the homeobox gene Hb9. In isolated whole spinal cords, cycle frequency was decreased in the presence of low-threshold calcium channel blockers, which suggests a role for I<jats:sub>Ca(T)<\/jats:sub>in the network that produces rhythmic, locomotor-like activity. Additionally, we used Hb9 interneurons as a model to study the cellular responses to application of low-threshold calcium channel blockers. In transverse slice preparations from transgenic Hb9::enhanced green fluorescent protein neonatal mice, N-methyl-d-aspartate-induced membrane potential oscillations in identified Hb9 interneurons also slowed in frequency with application of nickel when fast, spike-mediated, synaptic transmission was blocked with TTX. Voltage-clamp and immunolabeling experiments confirmed expression of I<jats:sub>Ca(T)<\/jats:sub>and channels, respectively, in Hb9 interneurons located in the ventromedial spinal cord. Taken together, these results provide support that T-type calcium currents play an important role in network-wide rhythm generation during chemically evoked, fictive locomotor activity.<\/jats:p>","DOI":"10.1152\/jn.00583.2011","type":"journal-article","created":{"date-parts":[[2011,10,13]],"date-time":"2011-10-13T04:37:54Z","timestamp":1318480674000},"page":"103-113","source":"Crossref","is-referenced-by-count":23,"title":["Low-threshold calcium currents contribute to locomotor-like activity in neonatal mice"],"prefix":"10.1152","volume":"107","author":[{"given":"Tatiana M.","family":"Anderson","sequence":"first","affiliation":[{"name":"Department of Neuroscience, University of Minnesota, Minneapolis, Minnesota;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew D.","family":"Abbinanti","sequence":"additional","affiliation":[{"name":"Department of Neurobiology and Behavior, Cornell University, Ithaca, New York; 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