{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T02:27:44Z","timestamp":1777343264680,"version":"3.51.4"},"reference-count":25,"publisher":"American Physiological Society","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Neurophysiology"],"published-print":{"date-parts":[[2010,1]]},"abstract":"<jats:p> Na<jats:sup>+<\/jats:sup>-activated K<jats:sup>+<\/jats:sup> (K<jats:sub>Na<\/jats:sub>) channels can be activated by Na<jats:sup>+<\/jats:sup> influx via ionotropic receptors and play a role in shaping synaptic transmission. In expression systems, K<jats:sub>Na<\/jats:sub> channels are modulated by G protein\u2013coupled receptors, but such a modulation has not been shown for the native channels. In this study, we examined whether K<jats:sub>Na<\/jats:sub> channels coupled to AMPA receptors are modulated by metabotropic glutamate receptors (mGluRs) in lamprey spinal cord neurons. Activation of mGluR1 strongly inhibited the AMPA-induced K<jats:sub>Na<\/jats:sub> current. However, when intracellular Ca<jats:sup>2+<\/jats:sup> was chelated with 1,2-bis(2-aminophenoxy)ethane- N,N,N\u2032, N\u2032-tetraacetic acid (BAPTA), the K<jats:sub>Na<\/jats:sub> current was enhanced by mGluR1. Activation of protein kinase C (PKC) mimicked the inhibitory effect of mGluR1 on the K<jats:sub>Na<\/jats:sub> current. Blockade of PKC prevented the mGluR1-induced inhibition of the K<jats:sub>Na<\/jats:sub> current, but did not affect the enhancement of the current seen in BAPTA. Together these results suggest that mGluR1 can differentially modulate AMPA-induced K<jats:sub>Na<\/jats:sub> current in a Ca<jats:sup>2+<\/jats:sup>- and PKC-dependent manner. <\/jats:p>","DOI":"10.1152\/jn.00584.2009","type":"journal-article","created":{"date-parts":[[2009,11,4]],"date-time":"2009-11-04T21:55:24Z","timestamp":1257371724000},"page":"441-445","source":"Crossref","is-referenced-by-count":13,"title":["Mechanisms of Modulation of AMPA-Induced Na<sup>+<\/sup>-Activated K<sup>+<\/sup> Current by mGluR1"],"prefix":"10.1152","volume":"103","author":[{"given":"Evanthia","family":"Nanou","sequence":"first","affiliation":[{"name":"Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdeljabbar","family":"El Manira","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1038\/317540a0"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0551-07.2007"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.23-37-11681.2003"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5978-08.2009"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1989.sp017533"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1997.78.3.1334"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-0173(02)00184-4"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresrev.2007.06.020"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00695.2002"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1007\/BF00376215"},{"key":"B10a","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.091096198"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00742.2006"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1038\/2176"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1152\/jn.01132.2002"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1998.80.3.1222"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1996.76.6.3834"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.20-14-05382.2000"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3174-07.2007"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0806403106"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2009.172452"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.20-11-04286.2000"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3372-05.2006"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2007.138156"},{"key":"B22a","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5308-06.2007"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(03)00096-5"}],"container-title":["Journal of Neurophysiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.physiology.org\/doi\/pdf\/10.1152\/jn.00584.2009","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,9]],"date-time":"2019-09-09T02:32:16Z","timestamp":1567996336000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.physiology.org\/doi\/10.1152\/jn.00584.2009"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,1]]},"references-count":25,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2010,1]]}},"alternative-id":["10.1152\/jn.00584.2009"],"URL":"https:\/\/doi.org\/10.1152\/jn.00584.2009","relation":{},"ISSN":["0022-3077","1522-1598"],"issn-type":[{"value":"0022-3077","type":"print"},{"value":"1522-1598","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,1]]}}}