{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T18:14:41Z","timestamp":1791656081532,"version":"4.3.4"},"reference-count":50,"publisher":"American Physiological Society","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Neurophysiology"],"published-print":{"date-parts":[[2005,11]]},"abstract":"<jats:p> Centrally expressed 5-HT<jats:sub>3<\/jats:sub> receptors (5-HTR<jats:sub>3<\/jats:sub>) are well known for their role in wakefulness, cognition, and nociception. However, clear evidence of their participation in motor control is still lacking despite specific 5-HTR<jats:sub>3<\/jats:sub> expression in hindlimb motor areas of the spinal cord (i.e., lumbar laminae VII-IX). Here, we studied the acute effects of 4-amino-(6-chloro-2-pyridyl)-1-piperidine hydrochloride (SR 57227A), a potent and selective 5-HTR<jats:sub>3<\/jats:sub> agonist, on hindlimb movement generation in complete paraplegic mice. The induced movements were assessed in open-field, air-stepping, and treadmill conditions using a combination of qualitative and quantitative methods. The results revealed that SR 57227A (1\u20134 mg\/kg ip) produced hindlimb movements corresponding to scores ranging from 1 to 5 on the motor scales of Basso, Beattie, and Bresnahan and of Antri, Orsal, and Barthe. Additional analyses revealed that one-third of the movements displayed on a treadmill were \u201clocomotor-like\u201d (i.e., bilateral alternation), whereas only nonlocomotor movements were observed in the other testing conditions suggesting a task-dependent contribution of peripheral afferent inputs to these effects. Locomotor-like movements could also be induced in open field and air stepping if SR 57227A was combined with subthreshold doses of 5-carboxytryptamine (5-HT<jats:sub>1A\/7<\/jats:sub> receptor agonist), suggesting synergistic actions of these drugs on central neurons. These results demonstrate that 5-HTR<jats:sub>3<\/jats:sub> activation can induce motor activity and, under some conditions, rhythmic locomotor-like movements in the hindlimbs of paraplegic mice providing evidence of an unsuspected role for this receptor subtype in hindlimb motor control. <\/jats:p>","DOI":"10.1152\/jn.00587.2005","type":"journal-article","created":{"date-parts":[[2005,7,28]],"date-time":"2005-07-28T00:34:01Z","timestamp":1122510841000},"page":"3397-3405","source":"Crossref","is-referenced-by-count":24,"title":["Ionotropic 5-HT<sub>3<\/sub> Receptor Agonist-Induced Motor Responses in the Hindlimbs of Paraplegic Mice"],"prefix":"10.1152","volume":"94","author":[{"given":"Pierre A.","family":"Guertin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inge","family":"Steuer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"R1","doi-asserted-by":"publisher","DOI":"10.1016\/S0891-0618(02)00072-8"},{"key":"R2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1990.tb16875.x"},{"key":"R3","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2005.04.062"},{"key":"R4","doi-asserted-by":"publisher","DOI":"10.1046\/j.1460-9568.2002.02088.x"},{"key":"R5","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(93)90282-M"},{"key":"R6","doi-asserted-by":"publisher","DOI":"10.1016\/S0028-3908(99)00010-6"},{"key":"R7","doi-asserted-by":"publisher","DOI":"10.1006\/exnr.1996.0098"},{"key":"R8","unstructured":"Blandina P, Goldfarb J, Craddock-Royal B, and Green JP. 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