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We observed distinct representations of leg and arm movement localized to the dorsal and ventral part of the posterior GPi, respectively. Comparing patients with generalized dystonia versus patients with segmental craniocervical dystonia, there was no difference in the volumes or separations of leg and arm related territories. In contrast to parkinsonism, only a small minority of units were responsive to movement across multiple joints. Abnormally increased directional selectivity was found in units responding to dystonic limbs compared with nondystonic limbs. Some affected GPi neurons therefore appear to have altered proprioceptive tuning for movement direction. There is an apparent preservation of GPi somatotopic organization in dystonia in comparison with prior studies of GPi somatotopic organization in non-human primates and humans with Parkinson's disease.<\/jats:p>","DOI":"10.1152\/jn.00594.2007","type":"journal-article","created":{"date-parts":[[2007,10,18]],"date-time":"2007-10-18T01:24:47Z","timestamp":1192670687000},"page":"3696-3707","source":"Crossref","is-referenced-by-count":23,"title":["Neuronal Responses to Passive Movement in the Globus Pallidus Internus in Primary Dystonia"],"prefix":"10.1152","volume":"98","author":[{"given":"Edward F.","family":"Chang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert S.","family":"Turner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jill L.","family":"Ostrem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valerie R.","family":"Davis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip A.","family":"Starr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"R1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pneurobio.2003.12.001"},{"key":"R2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410440520"},{"key":"R3","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.22-02-00592.2002"},{"key":"R4","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/121.7.1195"},{"key":"R5","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.35.1.73"},{"key":"R6","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.47.2.508"},{"key":"R7","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1990.64.1.151"},{"key":"R8","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awl355"},{"key":"R9","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000158424.01299.76"},{"key":"R10","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1971.34.3.414"},{"key":"R11","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1985.53.2.530"},{"key":"R12","doi-asserted-by":"publisher","DOI":"10.1214\/ss\/1032280214"},{"key":"R13","doi-asserted-by":"crossref","unstructured":"Eidelberg D.Abnormal brain networks in DYT1 dystonia.Adv Neurol78: 127\u2013133, 1998.","DOI":"10.1002\/ana.410440304"},{"key":"R14","doi-asserted-by":"publisher","DOI":"10.1097\/00001756-199811160-00006"},{"key":"R15","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-200409000-00011"},{"key":"R16","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(88)90924-9"},{"key":"R17","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awl068"},{"key":"R18","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropsychologia.2007.02.005"},{"key":"R19","doi-asserted-by":"publisher","DOI":"10.1002\/ana.20113"},{"key":"R20","unstructured":"Ghilani CD, Wolf PR.Adjustment Computations: Spatial Data Analysis(4th ed.). 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