{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,21]],"date-time":"2025-08-21T18:39:28Z","timestamp":1755801568285,"version":"3.44.0"},"reference-count":139,"publisher":"American Physiological Society","issue":"2","funder":[{"DOI":"10.13039\/100000065","name":"HHS | NIH | National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["R01 NS117058-01"],"award-info":[{"award-number":["R01 NS117058-01"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"HHS | NIH | National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["R01 NS070865-01A1"],"award-info":[{"award-number":["R01 NS070865-01A1"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100018231","name":"Aligning Science Across Parkinson's","doi-asserted-by":"publisher","award":["ASAP-020519"],"award-info":[{"award-number":["ASAP-020519"]}],"id":[{"id":"10.13039\/100018231","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.physiology.org"],"crossmark-restriction":true},"short-container-title":["Journal of Neurophysiology"],"published-print":{"date-parts":[[2025,8,1]]},"abstract":"<jats:p> Although the globus pallidus internus (GPi) plays a central role in the cardinal symptoms of Parkinson\u2019s disease (PD), how parkinsonism alters the movement-related activity of GPi neurons remains understudied. Using a monkey model of PD, we found that: 1) the timing of GPi responses became uncoupled from movement onset; and 2) responses, especially decrease-type responses, became attenuated and prolonged. These abnormalities in GPi perimovement activity may contribute to the generation of parkinsonian motor signs. <\/jats:p>","DOI":"10.1152\/jn.00611.2024","type":"journal-article","created":{"date-parts":[[2025,7,23]],"date-time":"2025-07-23T02:04:38Z","timestamp":1753236278000},"page":"741-765","update-policy":"https:\/\/doi.org\/10.1152\/aps-crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Movement-related activity in the internal globus pallidus of the parkinsonian macaque"],"prefix":"10.1152","volume":"134","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6787-5862","authenticated-orcid":false,"given":"Daisuke","family":"Kase","sequence":"first","affiliation":[{"name":"Center for Neuroscience and The Center for the Neural Basis of Cognition, University of Pittsburgh","place":["United States"]},{"name":"Aligning Science Across Parkinson\u2019s (ASAP) Collaborative Research Network","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8313-2476","authenticated-orcid":false,"given":"Andrew J.","family":"Zimnik","sequence":"additional","affiliation":[{"name":"Columbia University Medical Center","place":["United States"]},{"name":"Columbia University","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2881-1601","authenticated-orcid":false,"given":"Yan","family":"Han","sequence":"additional","affiliation":[{"name":"Center for Neuroscience and The Center for the Neural Basis of Cognition, University of Pittsburgh","place":["United States"]},{"name":"Xuanwu Hospital, Capital Medical University, National Center for Neurological Disorders","place":["People\u2019s Republic of China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6267-2871","authenticated-orcid":false,"given":"Devin R.","family":"Harsch","sequence":"additional","affiliation":[{"name":"Center for Neuroscience and The Center for the Neural Basis of Cognition, University of Pittsburgh","place":["United States"]},{"name":"Aligning Science Across Parkinson\u2019s (ASAP) Collaborative Research Network","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah","family":"Bacha","sequence":"additional","affiliation":[{"name":"Center for Neuroscience and The Center for the Neural Basis of Cognition, University of Pittsburgh","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5418-0508","authenticated-orcid":false,"given":"Karin M.","family":"Cox","sequence":"additional","affiliation":[{"name":"Center for Neuroscience and The Center for the Neural Basis of Cognition, University of Pittsburgh","place":["United States"]},{"name":"Aligning Science Across Parkinson\u2019s (ASAP) Collaborative Research Network","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4376-3836","authenticated-orcid":false,"given":"Andreea C.","family":"Bostan","sequence":"additional","affiliation":[{"name":"Center for Neuroscience and The Center for the Neural Basis of Cognition, University of Pittsburgh","place":["United States"]},{"name":"Aligning Science Across Parkinson\u2019s (ASAP) Collaborative Research Network","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2620-7387","authenticated-orcid":false,"given":"R. Mark","family":"Richardson","sequence":"additional","affiliation":[{"name":"Massachusetts General Hospital and Harvard Medical School","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6074-4365","authenticated-orcid":false,"given":"Robert S.","family":"Turner","sequence":"additional","affiliation":[{"name":"Center for Neuroscience and The Center for the Neural Basis of Cognition, University of Pittsburgh","place":["United States"]},{"name":"Aligning Science Across Parkinson\u2019s (ASAP) Collaborative Research Network","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-0173(94)00007-c"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410400305"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.22-02-00592.2002"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0447.1960.tb07606.x"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1007\/s00701-007-1242-x"},{"key":"B6","first-page":"787","volume":"73","author":"Birkmayer W","year":"1961","journal-title":"Wien Klin Wochenschr"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM196702162760703"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1016\/0166-2236(89)90074-x"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1016\/0166-2236(90)90110-v"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.3233\/JPD-130204"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00971.2004"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1038\/s41531-024-00773-4"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1002\/mds.27741"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0893-14.2014"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.3389\/fncir.2017.00034"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2009.179069"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1007\/s00221-008-1349-1"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1007\/BF00228859"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0523-05.2005"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awv312"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2008.05.023"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.64.1.20"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1016\/0165-0173(86)90009-3"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1985.54.2.433"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/114.4.1667"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(72)90118-7"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(95)00780-t"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1991.65.2.273"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(81)90693-4"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2006.04984.x"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/107.2.371"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/104.1.167"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/115.2.539"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1002\/brb3.2031"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1017\/s0033291700009077"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1007\/s00221-011-2610-6"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.3389\/fnsys.2011.00038"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e318253d5dd"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2007.05754.x"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1016\/S0079-6123(03)43043-4"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhab164"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.3000829"},{"volume-title":"Guide for the Care and Use of Laboratory Animals","year":"2011","author":"National Research Council (U.S.) Committee for the Update of the Guide for the Care and Use of Laboratory Animals, Institute for Laboratory Animal Research (U.S.), National Academies Press (U.S.)","key":"B43"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1152\/jn.01010.2007"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4899-14.2015"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2012.03.028"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awg139"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1002\/0471142301.ns0904s09"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneumeth.2006.12.007"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2006.11.053"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2015.00153"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhu062"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00680.2018"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2021.09.002"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2010.08.012"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1007\/s002210050696"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1985.53.4.926"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1152\/jn.91092.2008"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00055.2005"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2008.01.023"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1997.77.3.1051"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.1007\/BF00230536"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.2307\/2529686"},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.7275\/tbfa-x148"},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.1007\/978-0-387-32833-1_200"},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.1002\/0471721182"},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.1111\/j.0953-816x.2003.03088.x"},{"key":"B69","first-page":"142","volume":"547","author":"Filion M","year":"1991","journal-title":"Brain Res"},{"key":"B70","doi-asserted-by":"publisher","DOI":"10.1152\/jn.01013.2005"},{"key":"B71","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1994.72.2.507"},{"key":"B72","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2012.08108.x"},{"key":"B73","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.20-22-08559.2000"},{"key":"B74","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2016.03.002"},{"key":"B75","doi-asserted-by":"publisher","DOI":"10.1016\/s0959-4388(97)80005-0"},{"key":"B76","doi-asserted-by":"publisher","DOI":"10.1038\/nn1386"},{"key":"B77","doi-asserted-by":"publisher","DOI":"10.1002\/sim.4780040113"},{"key":"B78","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00508.2004"},{"key":"B79","doi-asserted-by":"publisher","DOI":"10.1007\/BF00241967"},{"key":"B80","doi-asserted-by":"publisher","DOI":"10.1007\/BF00227195"},{"key":"B81","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/116.4.869"},{"key":"B82","doi-asserted-by":"publisher","DOI":"10.1016\/s0304-3940(96)12943-8"},{"key":"B83","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.22-18-07850.2002"},{"key":"B84","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4684-5347-8_29"},{"key":"B85","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2024.106512"},{"key":"B86","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2023.113287"},{"key":"B87","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2010.01.018"},{"key":"B88","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2007.05777.x"},{"key":"B89","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3388-07.2008"},{"key":"B90","doi-asserted-by":"publisher","DOI":"10.1007\/s00221-012-3285-3"},{"key":"B91","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2011.07865.x"},{"key":"B92","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.42746"},{"key":"B93","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2015.08.022"},{"key":"B94","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1681-13.2013"},{"key":"B95","doi-asserted-by":"publisher","DOI":"10.3389\/fnhum.2010.00186"},{"key":"B96","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(79)90704-2"},{"key":"B97","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/124.11.2131"},{"key":"B98","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2019.03.004"},{"key":"B99","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2022.105686"},{"key":"B100","doi-asserted-by":"publisher","DOI":"10.1006\/exnr.1999.7072"},{"key":"B101","doi-asserted-by":"publisher","DOI":"10.1212\/wnl.51.2_suppl_2.s2"},{"key":"B102","doi-asserted-by":"publisher","DOI":"10.1016\/0197-0186(90)90148-m"},{"key":"B103","doi-asserted-by":"publisher","DOI":"10.1016\/S1353-8020(09)70804-1"},{"key":"B104","doi-asserted-by":"publisher","DOI":"10.1007\/s00429-005-0053-1"},{"key":"B105","doi-asserted-by":"publisher","DOI":"10.1002\/cne.24834"},{"key":"B106","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhab020"},{"key":"B107","doi-asserted-by":"publisher","DOI":"10.1007\/s00429-019-01967-w"},{"key":"B108","doi-asserted-by":"publisher","DOI":"10.1007\/s00429-013-0507-9"},{"key":"B109","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2013.09.008"},{"key":"B110","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhab313"},{"key":"B111","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2020.105159"},{"key":"B112","doi-asserted-by":"publisher","DOI":"10.1038\/nn.3047"},{"key":"B113","doi-asserted-by":"publisher","DOI":"10.1016\/s0306-4522(98)00319-4"},{"key":"B114","doi-asserted-by":"publisher","DOI":"10.1016\/j.conb.2010.08.022"},{"key":"B115","doi-asserted-by":"publisher","DOI":"10.1152\/jn.2000.83.3.1760"},{"key":"B116","doi-asserted-by":"publisher","DOI":"10.1111\/ejn.16166"},{"key":"B117","doi-asserted-by":"publisher","DOI":"10.1007\/s00702-017-1735-6"},{"key":"B118","doi-asserted-by":"publisher","DOI":"10.1002\/mds.28174"},{"key":"B119","doi-asserted-by":"publisher","DOI":"10.1038\/nature09159"},{"key":"B120","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1278-13.2013"},{"key":"B121","doi-asserted-by":"publisher","DOI":"10.1016\/s0301-0082(96)00042-1"},{"key":"B122","doi-asserted-by":"publisher","DOI":"10.1016\/s0959-4388(96)80024-9"},{"key":"B123","first-page":"1","volume-title":"Psychology of Learning and Motivation: Advances in Research and Theory","author":"Ashby FG","year":"2006"},{"key":"B124","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2005.05.005"},{"key":"B125","doi-asserted-by":"publisher","DOI":"10.1016\/0959-4388(95)80100-6"},{"key":"B126","doi-asserted-by":"publisher","DOI":"10.1038\/nature17639"},{"key":"B127","doi-asserted-by":"publisher","DOI":"10.1002\/mds.25702"},{"key":"B128","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2213093120"},{"key":"B129","doi-asserted-by":"publisher","DOI":"10.1042\/BST0350428"},{"key":"B130","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2018.04.014"},{"key":"B131","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2017.08.038"},{"key":"B132","doi-asserted-by":"publisher","DOI":"10.1007\/pl00005743"},{"key":"B133","doi-asserted-by":"publisher","DOI":"10.3390\/cells8091005"},{"key":"B134","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awv018"},{"key":"B135","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.31895"},{"key":"B136","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a009282"},{"key":"B137","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-neuro-061010-113641"},{"key":"B138","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1204-20.2020"},{"key":"B139","doi-asserted-by":"publisher","DOI":"10.1016\/S0079-6123(08)62678-3"},{"key":"B140","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5050-05.2006"}],"container-title":["Journal of Neurophysiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.physiology.org\/doi\/pdf\/10.1152\/jn.00611.2024","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,20]],"date-time":"2025-08-20T18:00:30Z","timestamp":1755712830000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.physiology.org\/doi\/10.1152\/jn.00611.2024"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,1]]},"references-count":139,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,8,1]]}},"alternative-id":["10.1152\/jn.00611.2024"],"URL":"https:\/\/doi.org\/10.1152\/jn.00611.2024","relation":{},"ISSN":["0022-3077","1522-1598"],"issn-type":[{"type":"print","value":"0022-3077"},{"type":"electronic","value":"1522-1598"}],"subject":[],"published":{"date-parts":[[2025,8,1]]},"assertion":[{"value":"2024-12-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-01-27","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-07-08","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-20","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}