{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T12:36:40Z","timestamp":1791981400728,"version":"4.4.0"},"reference-count":69,"publisher":"American Physiological Society","issue":"4","funder":[{"DOI":"10.13039\/100000050","name":"HHS | NIH | National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["F31 HL160191"],"award-info":[{"award-number":["F31 HL160191"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"HHS | NIH | National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R01HL104101"],"award-info":[{"award-number":["R01HL104101"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"HHS | NIH | National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R01HL137094"],"award-info":[{"award-number":["R01HL137094"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"HHS | NIH | National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["R21NS134132"],"award-info":[{"award-number":["R21NS134132"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000025","name":"HHS | NIH | National Institute of Mental Health","doi-asserted-by":"publisher","award":["R01MH112739"],"award-info":[{"award-number":["R01MH112739"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"HHS | NIH | National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["R01NS131664"],"award-info":[{"award-number":["R01NS131664"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.physiology.org"],"crossmark-restriction":true},"short-container-title":["Journal of Neurophysiology"],"published-print":{"date-parts":[[2026,4,1]]},"abstract":"<jats:p>This work provides the first characterization of the axonal projections and distinctive electrophysiological properties that define thyrotropin-releasing hormone (TRH)-expressing neurons in the mouse lateral hypothalamic area (LHA) in acute brain slices. We find that a large majority of LHA TRH neurons exhibit robust rebound burst firing, with a smaller subpopulation exhibiting spontaneous rhythmic burst firing. Together, these findings advance our understanding of how LHA TRH neurons may contribute to regulating physiology and behavior.<\/jats:p>","DOI":"10.1152\/jn.00616.2024","type":"journal-article","created":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T17:01:01Z","timestamp":1773766861000},"page":"965-982","update-policy":"https:\/\/doi.org\/10.1152\/aps-crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["Cellular properties and axonal projections of thyrotropin-releasing hormone-expressing neurons in the mouse lateral hypothalamic area"],"prefix":"10.1152","volume":"135","author":[{"given":"Maggie A.","family":"Khuu","sequence":"first","affiliation":[{"name":"University of Connecticut","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monica S.","family":"Antony","sequence":"additional","affiliation":[{"name":"University of Connecticut","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeremy H.","family":"Lesser","sequence":"additional","affiliation":[{"name":"University of Connecticut","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristen S.","family":"Springer","sequence":"additional","affiliation":[{"name":"University of Connecticut","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eneida M.","family":"Wainman","sequence":"additional","affiliation":[{"name":"University of Connecticut","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Falyne C.","family":"Driver","sequence":"additional","affiliation":[{"name":"University of Connecticut","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7040-3927","authenticated-orcid":false,"given":"Daniel K.","family":"Mulkey","sequence":"additional","affiliation":[{"name":"University of Connecticut","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7489-3946","authenticated-orcid":false,"given":"Alexander C.","family":"Jackson","sequence":"additional","affiliation":[{"name":"University of Connecticut","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1016\/j.physbeh.2011.04.051"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1016\/j.physbeh.2013.03.023"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.3389\/fnsys.2015.00009"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1113\/JP271946"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1016\/j.conb.2017.03.020"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2023.05.010"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1038\/s41593-019-0349-8"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2021.11.024"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.3389\/fnsys.2017.00032"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2020.107993"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1159\/000514964"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1093\/function\/zqad059"},{"key":"B13","first-page":"1870","volume":"269","author":"Burgus R","year":"1969","journal-title":"C R Acad Hebd Seances Acad Sci D"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1016\/0006-291x(69)90868-7"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1016\/S0079-6123(06)53012-2"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1210\/er.2013-1087"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1007\/s11154-016-9375-y"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2014.06.043"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0431-09.2009"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1016\/j.yfrne.2018.06.006"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1210\/en.2009-0976"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2976-08.2009"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1002\/cne.22017"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5966-11.2012"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2012.10.010"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1007\/s00429-017-1553-5"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1007\/s00429-022-02527-5"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1038\/nature12956"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.274.25.17771"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1016\/s0896-6273(03)00331-3"},{"key":"B31","volume-title":"The Mouse Brain in Stereotaxic Coordinates","author":"Paxinos G","year":"2008","edition":"3"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2202-7-11"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00079.2015"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.3125"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1126\/science.3925552"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1999.87.2.673"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1997.83.3.792"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2011.208637"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00018.2002"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2021.741292"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1113\/JP281510"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0839-12.2012"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0117-17.2017"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00593.2003"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2018.00070"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2600-20.2021"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1002\/cne.25588"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2024.1439752"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2004.03815.x"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.44927"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2022.936160"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1063\/5.0059338"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2009.12.024"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2016.03.062"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2010.01.013"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-444-63274-6.00001-1"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5759-10.2011"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1038\/nature25509"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2019.02.048"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2007.0251"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygcen.2009.05.003"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1523\/ENEURO.0315-21.2021"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-819975-6.00009-1"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.3389\/fncir.2017.00086"},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.1016\/s0149-7634(01)00048-3"},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2021.03.033"},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.1002\/1096-9861(20001211)428:2<319::AID-CNE10>3.0.CO;2-9"},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.31083\/j.jin2102047"},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2007.11.002"}],"container-title":["Journal of Neurophysiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.physiology.org\/doi\/pdf\/10.1152\/jn.00616.2024","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T16:01:58Z","timestamp":1776355318000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.physiology.org\/doi\/10.1152\/jn.00616.2024"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,1]]},"references-count":69,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,4,1]]}},"alternative-id":["10.1152\/jn.00616.2024"],"URL":"https:\/\/doi.org\/10.1152\/jn.00616.2024","relation":{},"ISSN":["0022-3077","1522-1598"],"issn-type":[{"value":"0022-3077","type":"print"},{"value":"1522-1598","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,1]]},"assertion":[{"value":"2024-12-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-01-09","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-21","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-16","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}