{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T17:13:10Z","timestamp":1789060390182,"version":"build-2803163510"},"reference-count":58,"publisher":"American Physiological Society","issue":"4","funder":[{"DOI":"10.13039\/501100000272","name":"National Institute for Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.physiology.org"],"crossmark-restriction":true},"short-container-title":["Journal of Neurophysiology"],"published-print":{"date-parts":[[2021,4,1]]},"abstract":"<jats:p> Transcranial magnetic stimulation of the primary motor cortex (M1) is a promising treatment for chronic pain, but its mechanism of action remains unclear. Competing dynamic causal models of effective connectivity between M1 and medial and lateral pain systems suggest direct input into the insular, anterior cingulate cortex, and parietal operculum. This supports the hypothesis that analgesia produced from M1 stimulation most likely acts through the activation of top-down processes associated with intracortical modulation. <\/jats:p>","DOI":"10.1152\/jn.00670.2020","type":"journal-article","created":{"date-parts":[[2021,2,24]],"date-time":"2021-02-24T21:44:08Z","timestamp":1614203048000},"page":"1180-1190","update-policy":"https:\/\/doi.org\/10.1152\/aps-crossmark-policy","source":"Crossref","is-referenced-by-count":24,"title":["Operculo-insular and anterior cingulate plasticity induced by transcranial magnetic stimulation in the human motor cortex: a dynamic casual modeling study"],"prefix":"10.1152","volume":"125","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3938-5254","authenticated-orcid":false,"given":"Duncan J.","family":"Hodkinson","sequence":"first","affiliation":[{"name":"Division of Clinical Neuroscience, School of Medicine, University of Nottingham, Nottingham, United Kingdom"},{"name":"Sir Peter Mansfield Imaging Centre, School of Medicine, University of Nottingham, Nottingham, United Kingdom"},{"name":"National Institute for Health Research, Nottingham Biomedical         Research Centre, Queen's Medical Center, Nottingham, United Kingdom"},{"name":"Versus Arthritis Pain Centre, University of Nottingham, Nottingham, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Bungert","sequence":"additional","affiliation":[{"name":"Sir Peter Mansfield Imaging Centre, School of Medicine, University of Nottingham, Nottingham, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Bowtell","sequence":"additional","affiliation":[{"name":"Sir Peter Mansfield Imaging Centre, School of Medicine, University of Nottingham, Nottingham, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen R.","family":"Jackson","sequence":"additional","affiliation":[{"name":"School of Psychology, University of Nottingham, Nottingham, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3739-7331","authenticated-orcid":false,"given":"JeYoung","family":"Jung","sequence":"additional","affiliation":[{"name":"School of Psychology, University of Nottingham, Nottingham, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2014.05.021"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2012.04.009"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1007\/s00221-007-0991-3"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1016\/j.brs.2008.06.006"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2003.09.017"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1186\/1744-8069-3-9"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1126\/science.288.5472.1765"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1038\/nrn2169"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2010.190314"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhs147"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1038\/nn.3422"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1016\/j.brs.2015.01.404"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1911240117"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2012.03.035"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2003.07.028"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bht023"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.22-02-00554.2002"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1097\/00001756-200111160-00034"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1016\/s0006-3223(98)00368-0"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1097\/00004424-200011000-00005"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1002\/1522-2586(200006)11:6<569::aid-jmri1>3.0.co;2-3"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2004.12.017"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1016\/j.brs.2015.09.008"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.3389\/fnhum.2020.00031"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00850.2014"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2017.10.028"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.3389\/fnsys.2010.00040"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.2005.1652"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2005.05.027"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhm128"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1089\/brain.2011.0008"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1038\/s41593-017-0054-4"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1038\/nn.2773"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2009.11.062"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1016\/S1053-8119(03)00202-7"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2005.10.045"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhr363"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.6207-10.2011"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpain.2015.05.001"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2015.01.056"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5664-09.2010"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhv308"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.1997.0291"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1089\/brain.2012.0073"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2007.04.042"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1093\/scan\/nss055"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2004.07.041"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2009.03.025"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1000709"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2011.138"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3495(86)83558-5"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2008.02.004"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awr265"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1157.2000.tb00228.x"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awq220"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3959(99)00021-4"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpain.2009.10.002"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1113\/JP276359"}],"container-title":["Journal of Neurophysiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.physiology.org\/doi\/pdf\/10.1152\/jn.00670.2020","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,6,29]],"date-time":"2021-06-29T20:21:24Z","timestamp":1624998084000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.physiology.org\/doi\/10.1152\/jn.00670.2020"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4,1]]},"references-count":58,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2021,4,1]]}},"alternative-id":["10.1152\/jn.00670.2020"],"URL":"https:\/\/doi.org\/10.1152\/jn.00670.2020","relation":{},"ISSN":["0022-3077","1522-1598"],"issn-type":[{"value":"0022-3077","type":"print"},{"value":"1522-1598","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,4,1]]},"assertion":[{"value":"2020-12-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-02-12","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-04-09","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}