{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T12:41:48Z","timestamp":1790167308186,"version":"4.1.0"},"reference-count":47,"publisher":"American Physiological Society","issue":"4","funder":[{"DOI":"10.13039\/100000050","name":"HHS | NIH | National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["1R61HL156248-01"],"award-info":[{"award-number":["1R61HL156248-01"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.physiology.org"],"crossmark-restriction":true},"short-container-title":["Journal of Neurophysiology"],"published-print":{"date-parts":[[2021,4,1]]},"abstract":"<jats:p> When life-threatening doses of fentanyl are used in mice, the \u03b2-arrestin 2 pathway appears to play a critical role in the recovery from opioid overdose. This observation calls into question the use of G protein-biased \u03bc-opioid receptor agonists, as a strategy for safer opioid analgesic drugs. <\/jats:p>","DOI":"10.1152\/jn.00711.2020","type":"journal-article","created":{"date-parts":[[2021,3,3]],"date-time":"2021-03-03T19:07:53Z","timestamp":1614798473000},"page":"1396-1407","update-policy":"https:\/\/doi.org\/10.1152\/aps-crossmark-policy","source":"Crossref","is-referenced-by-count":23,"title":["Respiratory effects of low and high doses of fentanyl in control and \u03b2-arrestin 2-deficient mice"],"prefix":"10.1152","volume":"125","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8181-4254","authenticated-orcid":false,"given":"Philippe","family":"Haouzi","sequence":"first","affiliation":[{"name":"Division of Pulmonary and Critical Care Medicine, Department of Medicine, Pennsylvania State University, College of Medicine, Hershey, Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marissa","family":"McCann","sequence":"additional","affiliation":[{"name":"Division of Pulmonary and Critical Care Medicine, Department of Medicine, Pennsylvania State University, College of Medicine, Hershey, Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole","family":"Tubbs","sequence":"additional","affiliation":[{"name":"Division of Pulmonary and Critical Care Medicine, Department of Medicine, Pennsylvania State University, College of Medicine, Hershey, Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0000000000003156"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1016\/j.resp.2020.103428"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2002.023408"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1016\/s0896-6273(03)00092-8"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-200109000-00029"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.2011.01482.x"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-41199-1_22"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1089\/104454900314465"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.17.9914"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-08162-1"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.105.087254"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1016\/j.coph.2016.11.007"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2007.06.006"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1097\/FBP.0b013e32835f3d2f"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1111\/bph.15004"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1016\/0041-008x(64)90021-3"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1996.81.2.521"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2013.261396"},{"key":"B19","first-page":"1011","volume-title":"Regulation of Breathing","author":"Mortola JP","year":"1995"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-50613-2"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1007\/BF02244050"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.2001.00599.x"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1126\/science.286.5449.2495"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1016\/j.resp.2009.06.006"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00335.2011"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1016\/j.resp.2013.02.001"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1016\/s0885-3924(97)00371-0"},{"key":"B28","first-page":"368","volume":"201","author":"Brase DA","year":"1977","journal-title":"J Pharmacol Exp Ther"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.3109\/15563650.2016.1157722"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1186\/s12954-018-0271-5"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-198906000-00017"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmcr.2017.02.012"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1113\/expphysiol.2008.042424"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(86)91301-6"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2013.261974"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aen094"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(97)01105-0"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1016\/0034-5687(91)90043-i"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.01013.2014"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1016\/j.resp.2010.04.013"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1606267113"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0b013e3182227550"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.102.037655"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1681.1998.tb02197.x"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1995.79.1.256"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.110.231308"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1016\/j.coph.2014.04.002"}],"container-title":["Journal of Neurophysiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.physiology.org\/doi\/pdf\/10.1152\/jn.00711.2020","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,6,23]],"date-time":"2021-06-23T09:38:37Z","timestamp":1624441117000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.physiology.org\/doi\/10.1152\/jn.00711.2020"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4,1]]},"references-count":47,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2021,4,1]]}},"alternative-id":["10.1152\/jn.00711.2020"],"URL":"https:\/\/doi.org\/10.1152\/jn.00711.2020","relation":{},"ISSN":["0022-3077","1522-1598"],"issn-type":[{"value":"0022-3077","type":"print"},{"value":"1522-1598","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,4,1]]},"assertion":[{"value":"2020-12-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-03-01","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-04-19","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}