{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T02:21:05Z","timestamp":1771294865657,"version":"3.50.1"},"reference-count":38,"publisher":"American Physiological Society","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Neurophysiology"],"published-print":{"date-parts":[[2003,6]]},"abstract":"<jats:p> Most mammals modulate respiratory frequency (RF) to dissipate heat (i.e., panting) and avoid heat stroke during hyperthermic conditions. During hyperthermia, the RF of intact mammals increases and then declines or ceases (apnea). It has been proposed that this RF modulation depends on the presence of higher brain structures such as the hypothalamus. However, the direct effects of hyperthermia on the respiratory neural network have not been examined. To address this issue, the respiratory neural network [i.e., ventral respiratory group (VRG)] was isolated in a brain stem preparation taken from the medulla of mice (P0 \u2013P6). Integrated population activity, predominated by inspiratory neurons, was recorded extracellularly from VRG neurons. The bath temperature was then heated from 30 to 40\u00b0C, resulting in a biphasic frequency response in VRG activity. Following an initial six- to sevenfold increase and subsequent decline, fictive RF was maintained at a frequency that was higher than baseline frequency; at 40\u00b0C, the RF was maintained at about two to four times that at 30\u00b0C. The inspiratory burst amplitude and duration were significantly reduced during hyperthermic conditions. An increase in RF and decrease in VRG burst amplitude and duration also occurred when heating from 37 to 40\u00b0C. Fictive apnea typically occurred during cooling to the control temperature. Furthermore, changes in hypoglossal motor nucleus activity paralleled those of the VRG, suggesting that temperature modulation of the VRG is likely to have a behaviorally relevant impact on respiration. We conclude that the VRG activity itself is modulated during hyperthermia and the respiratory network is particularly sensitive to temperature changes. <\/jats:p>","DOI":"10.1152\/jn.00743.2002","type":"journal-article","created":{"date-parts":[[2006,5,31]],"date-time":"2006-05-31T02:01:10Z","timestamp":1149040870000},"page":"2975-2983","source":"Crossref","is-referenced-by-count":40,"title":["Response of the Respiratory Network of Mice to Hyperthermia"],"prefix":"10.1152","volume":"89","author":[{"given":"Andrew K.","family":"Tryba","sequence":"first","affiliation":[{"name":"Department of Organismal Biology and Anatomy, The University of Chicago,  Chicago, Illinois 60637-1508"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan-Marino","family":"Ramirez","sequence":"additional","affiliation":[{"name":"Department of Organismal Biology and Anatomy, The University of Chicago,  Chicago, Illinois 60637-1508"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"24","reference":[{"key":"REF1","unstructured":"Altman PL and  Dittmaer, DS. Environmental Biology. Bethesda, MD:  Federation of American Societies for Experimental Biology,  1966."},{"key":"REF2","doi-asserted-by":"publisher","DOI":"10.1152\/jn.2002.87.6.2964"},{"key":"REF3","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1984.56.1.84"},{"key":"atypb1","doi-asserted-by":"crossref","unstructured":"Elsen FP and  Ramirez JM. Calcium currents of rhythmic neurons recorded in the isolated  respiratory network of neonatal mice. J Neurosci 18: 10652\u201310662,  1988.","DOI":"10.1523\/JNEUROSCI.18-24-10652.1998"},{"key":"REF5","doi-asserted-by":"publisher","DOI":"10.1016\/0300-9572(90)90048-J"},{"key":"REF6","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.301.6743.85"},{"key":"REF7","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1998.84.3.877"},{"key":"REF8","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1994.72.5.2538"},{"key":"REF9","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-199310000-00028"},{"key":"REF10","doi-asserted-by":"publisher","DOI":"10.1016\/0301-0082(93)90014-J"},{"key":"REF11","doi-asserted-by":"publisher","DOI":"10.1016\/S0034-5687(99)00107-3"},{"key":"REF12","doi-asserted-by":"crossref","unstructured":"Hubbard RW,  Matthew WT, Linduska JD, Curtis FC, Bowers WD, Leav I, and Mager M. The  laboratory rat as a model for hyperthermic syndromes in humans. Am  J Physiol 231:  1119\u20131123, 1976.","DOI":"10.1152\/ajplegacy.1976.231.4.1119"},{"key":"REF13","doi-asserted-by":"crossref","unstructured":"Inamasu J, Suga  S, Sato S, Horiguchi T, Akaji K, Mayanagi K, and Kawase T. Postischemic  hypothermia attenuates apoptotic cell death in transient focal ischemia in  rats. Acta Neurochirurgica Suppl 76: 525\u2013527,  2000.","DOI":"10.1007\/978-3-7091-6346-7_110"},{"key":"REF14","doi-asserted-by":"publisher","DOI":"10.1007\/BF00581063"},{"key":"atypb2","doi-asserted-by":"crossref","unstructured":"Kelty JD,  Noseworthy PA, Feder ME, Robertson RM, and Ramirez J-M. Thermal  preconditioning and heat-shock protein 72 preserve synaptic transmission  during thermal stress. J Neurosci 22: 1\u20136,  2002.","DOI":"10.1523\/JNEUROSCI.22-01-j0004.2002"},{"key":"REF16","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1983.55.2.483"},{"key":"REF17","doi-asserted-by":"publisher","DOI":"10.1038\/71077"},{"key":"REF18","doi-asserted-by":"publisher","DOI":"10.1071\/RD9960079"},{"key":"REF19","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00049.2001"},{"key":"REF20","doi-asserted-by":"publisher","DOI":"10.1016\/S0034-5687(98)00071-1"},{"key":"REF21","doi-asserted-by":"publisher","DOI":"10.1016\/S0034-5687(99)00059-6"},{"key":"REF22","doi-asserted-by":"crossref","unstructured":"Pleschka K and  Wang SC. The activity of respiratory neurons before and during panting.  Pfluegers Arch 353:  303\u2013315, 1997.","DOI":"10.1007\/BF00587027"},{"key":"REF23","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-199903000-00010"},{"key":"REF24","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1997.78.1.383"},{"key":"REF25","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1996.sp021258"},{"key":"REF26","doi-asserted-by":"crossref","unstructured":"Richter DW,  Bischoff A, Anders K, Bellingham M, and Windhorst U. Response of the  medullary network of the cat to hypoxia. J Physiol 442: 231\u2013256,  1991.","DOI":"10.1113\/jphysiol.1991.sp018832"},{"key":"REF27","doi-asserted-by":"publisher","DOI":"10.1054\/mehy.2000.1405"},{"key":"REF28","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1996.sp021213"},{"key":"atypb3","doi-asserted-by":"publisher","DOI":"10.1126\/science.1683005"},{"key":"atypb4","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1990.64.4.1149"},{"key":"REF31","doi-asserted-by":"publisher","DOI":"10.1016\/S0034-5687(00)00178-X"},{"key":"REF32","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1985.59.4.1201"},{"key":"REF33","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1999.82.5.2163"},{"key":"REF34","unstructured":"Tryba AK and  Ramirez JM. Bi-phasic response of the isolated respiratory network to  hyperthermia. Soc Neurosci Abst 27: 730.6,  2001."},{"key":"atypb5","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1996.sp021143"},{"key":"REF36","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-4975(98)00911-4"},{"key":"REF37","doi-asserted-by":"crossref","unstructured":"Weiner D, Mitra  J, Salamone J, and Cherniak NS. Effect of chemical stimuli on nerves  supplying upper airway muscles. J Appl Physiol 3: 530\u2013536,  1982.","DOI":"10.1152\/jappl.1982.52.3.530"},{"key":"REF38","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/17.2.455"}],"container-title":["Journal of Neurophysiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.physiology.org\/doi\/pdf\/10.1152\/jn.00743.2002","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,9]],"date-time":"2019-09-09T00:28:02Z","timestamp":1567988882000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.physiology.org\/doi\/10.1152\/jn.00743.2002"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,6]]},"references-count":38,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2003,6]]}},"alternative-id":["10.1152\/jn.00743.2002"],"URL":"https:\/\/doi.org\/10.1152\/jn.00743.2002","relation":{},"ISSN":["0022-3077","1522-1598"],"issn-type":[{"value":"0022-3077","type":"print"},{"value":"1522-1598","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,6]]}}}