{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T01:29:38Z","timestamp":1792718978901,"version":"4.5.0"},"reference-count":31,"publisher":"American Physiological Society","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Neurophysiology"],"published-print":{"date-parts":[[2011,12]]},"abstract":"<jats:p>Chronic compression (CCD) of the dorsal root ganglion (DRG) is a model of human radicular pain produced by intraforaminal stenosis and other disorders affecting the DRG, spinal nerve, or root. Previously, we examined electrophysiological changes in small-diameter lumbar level 3 (L3) and L4 DRG neurons treated with CCD; the present study extends these observations to medium-sized DRG neurons, which mediate additional sensory modalities, both nociceptive and non-nociceptive. Whole-cell patch-clamp recordings were obtained from medium-sized somata in the intact DRG in vitro. Compared with neurons from unoperated control animals, CCD neurons exhibited a decrease in the current threshold for action potential generation. In the CCD group, current densities of TTX-resistant and TTX-sensitive Na<jats:sup>+<\/jats:sup>current were increased, whereas the density of delayed rectifier voltage-dependent K<jats:sup>+<\/jats:sup>current was decreased. No change was observed in the transient or \u201cA\u201d current after CCD. We conclude that CCD in the mouse produces hyperexcitability in medium-sized DRG neurons, and the hyperexcitability is associated with an increased density of Na<jats:sup>+<\/jats:sup>current and a decreased density of delayed rectifier voltage-dependent K<jats:sup>+<\/jats:sup>current.<\/jats:p>","DOI":"10.1152\/jn.00752.2011","type":"journal-article","created":{"date-parts":[[2011,9,15]],"date-time":"2011-09-15T07:36:17Z","timestamp":1316072177000},"page":"3067-3072","source":"Crossref","is-referenced-by-count":33,"title":["Chronic compression of mouse dorsal root ganglion alters voltage-gated sodium and potassium currents in medium-sized dorsal root ganglion neurons"],"prefix":"10.1152","volume":"106","author":[{"given":"Ni","family":"Fan","sequence":"first","affiliation":[{"name":"Deparments of 1Anesthesiology and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David F.","family":"Donnelly","sequence":"additional","affiliation":[{"name":"Pediatrics, Yale University School of Medicine, New Haven, Connecticut"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert H.","family":"LaMotte","sequence":"additional","affiliation":[{"name":"Deparments of 1Anesthesiology and"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.2001.85.2.644"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2003.12.035"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00264.2007"},{"key":"B4","doi-asserted-by":"crossref","first-page":"1460","DOI":"10.1111\/j.1471-4159.2010.06863.x","volume":"114","author":"Cao XH","year":"2010","journal-title":"J Neurochem"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3388-05.2006"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2011.01.033"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1999.82.2.700"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00065.2011"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(98)00568-X"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2006.03.049"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1097\/00001756-199711100-00008"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2211-06.2006"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3699-07.2007"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00855.2002"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3959(96)03105-3"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1038\/384360a0"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.15-11-07633.1995"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1097\/00000539-200104000-00042"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1999.82.6.3347"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2003.046409"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2005.11.024"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00830.2005"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1097\/00001756-199804200-00003"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2011.04.015"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1097\/01.anes.0000270761.99469.a7"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00560.2005"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2003.11.014"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.19-11-04644.1999"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1002\/glia.20872"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-0270(97)00164-7"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1999.82.6.3359"}],"container-title":["Journal of Neurophysiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.physiology.org\/doi\/pdf\/10.1152\/jn.00752.2011","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,11]],"date-time":"2024-04-11T16:05:48Z","timestamp":1712851548000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.physiology.org\/doi\/10.1152\/jn.00752.2011"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,12]]},"references-count":31,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2011,12]]}},"alternative-id":["10.1152\/jn.00752.2011"],"URL":"https:\/\/doi.org\/10.1152\/jn.00752.2011","relation":{},"ISSN":["0022-3077","1522-1598"],"issn-type":[{"value":"0022-3077","type":"print"},{"value":"1522-1598","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,12]]}}}